Crowdsourcing biomedical research: leveraging communities as innovation engines
Saez-Rodriguez, Julio, Costello, James C., Friend, Stephen H., Kellen, Michael R., Mangravite, Lara, Meyer, Pablo, Norman, Thea, Stolovitzky, Gustavo
Published in Nature reviews. Genetics (01.08.2016)
Published in Nature reviews. Genetics (01.08.2016)
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Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection
Ewing, Adam D, Houlahan, Kathleen E, Hu, Yin, Ellrott, Kyle, Caloian, Cristian, Yamaguchi, Takafumi N, Bare, J Christopher, P'ng, Christine, Waggott, Daryl, Sabelnykova, Veronica Y, Kellen, Michael R, Norman, Thea C, Haussler, David, Friend, Stephen H, Stolovitzky, Gustavo, Margolin, Adam A, Stuart, Joshua M, Boutros, Paul C
Published in Nature methods (01.07.2015)
Published in Nature methods (01.07.2015)
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Inferring causal molecular networks: empirical assessment through a community-based effort
Hill, Steven M, Heiser, Laura M, Cokelaer, Thomas, Unger, Michael, Nesser, Nicole K, Carlin, Daniel E, Zhang, Yang, Sokolov, Artem, Paull, Evan O, Wong, Chris K, Graim, Kiley, Bivol, Adrian, Wang, Haizhou, Zhu, Fan, Afsari, Bahman, Danilova, Ludmila V, Favorov, Alexander V, Lee, Wai Shing, Taylor, Dane, Hu, Chenyue W, Long, Byron L, Noren, David P, Bisberg, Alexander J, Mills, Gordon B, Gray, Joe W, Kellen, Michael, Norman, Thea, Friend, Stephen, Qutub, Amina A, Fertig, Elana J, Guan, Yuanfang, Song, Mingzhou, Stuart, Joshua M, Spellman, Paul T, Koeppl, Heinz, Stolovitzky, Gustavo, Saez-Rodriguez, Julio, Mukherjee, Sach
Published in Nature methods (01.04.2016)
Published in Nature methods (01.04.2016)
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Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms
Schaffter, Thomas, Buist, Diana S M, Lee, Christoph I, Nikulin, Yaroslav, Ribli, Dezso, Guan, Yuanfang, Lotter, William, Jie, Zequn, Du, Hao, Wang, Sijia, Feng, Jiashi, Feng, Mengling, Kim, Hyo-Eun, Albiol, Francisco, Albiol, Alberto, Morrell, Stephen, Wojna, Zbigniew, Ahsen, Mehmet Eren, Asif, Umar, Jimeno Yepes, Antonio, Yohanandan, Shivanthan, Rabinovici-Cohen, Simona, Yi, Darvin, Hoff, Bruce, Yu, Thomas, Chaibub Neto, Elias, Rubin, Daniel L, Lindholm, Peter, Margolies, Laurie R, McBride, Russell Bailey, Rothstein, Joseph H, Sieh, Weiva, Ben-Ari, Rami, Harrer, Stefan, Trister, Andrew, Friend, Stephen, Norman, Thea, Sahiner, Berkman, Strand, Fredrik, Guinney, Justin, Stolovitzky, Gustavo, Mackey, Lester, Cahoon, Joyce, Shen, Li, Sohn, Jae Ho, Trivedi, Hari, Shen, Yiqiu, Buturovic, Ljubomir, Pereira, Jose Costa, Cardoso, Jaime S, Castro, Eduardo, Kalleberg, Karl Trygve, Pelka, Obioma, Nedjar, Imane, Geras, Krzysztof J, Nensa, Felix, Goan, Ethan, Koitka, Sven, Caballero, Luis, Cox, David D, Krishnaswamy, Pavitra, Pandey, Gaurav, Friedrich, Christoph M, Perrin, Dimitri, Fookes, Clinton, Shi, Bibo, Cardoso Negrie, Gerard, Kawczynski, Michael, Cho, Kyunghyun, Khoo, Can Son, Lo, Joseph Y, Sorensen, A Gregory, Jung, Hwejin
Published in JAMA network open (02.03.2020)
Published in JAMA network open (02.03.2020)
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Optimized clinical performance of growth hormone with an expanded genetic code
Cho, Ho, Daniel, Tom, Buechler, Ying Ji, Litzinger, David C, Maio, Zhenwei, Putnam, Anna-Maria Hays, Kraynov, Vadim S, Sim, Bee-Cheng, Bussell, Stuart, Javahishvili, Tsotne, Kaphle, Sami, Viramontes, Guillermo, Ong, Mike, Chu, Stephanie, GC, Becky, Lieu, Ricky, Knudsen, Nick, Castiglioni, Paola, Norman, Thea C, Axelrod, Douglas W, Hoffman, Andrew R, Schultz, Peter G, DiMarchi, Richard D, Kimmel, Bruce E
Published in Proceedings of the National Academy of Sciences - PNAS (31.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (31.05.2011)
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FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
MU, James, PINKSTAFF, Jason, WU, Margaret, NORMAN, Thea C, RODRIGUEZ, Carlos G, KIMMEL, Bruce, METZGER, Joseph M, MANIBUSAN, Anthony, LEE, Darin, ZALLER, Dennis M, ZHANG, Bei B, DIMARCHI, Richard D, ZHIHUA LI, BERGER, Joel P, AXELROD, Douglas W, SKIDMORE, Lillian, NINA LI, MYLER, Heather, DALLAS-YANG, Qing, PUTNAM, Anna-Maria, JUN YAO, BUSSELL, Stuart
Published in Diabetes (New York, N.Y.) (01.02.2012)
Published in Diabetes (New York, N.Y.) (01.02.2012)
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Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection
Lee, Anna Y, Ewing, Adam D, Ellrott, Kyle, Hu, Yin, Houlahan, Kathleen E, Bare, J Christopher, Espiritu, Shadrielle Melijah G, Huang, Vincent, Dang, Kristen, Chong, Zechen, Caloian, Cristian, Yamaguchi, Takafumi N, Kellen, Michael R, Chen, Ken, Norman, Thea C, Friend, Stephen H, Guinney, Justin, Stolovitzky, Gustavo, Haussler, David, Margolin, Adam A, Stuart, Joshua M, Boutros, Paul C
Published in Genome Biology (06.11.2018)
Published in Genome Biology (06.11.2018)
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Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
Allen, Genevera I, Amoroso, Nicola, Anghel, Catalina, Balagurusamy, Venkat, Bare, Christopher J, Beaton, Derek, Bellotti, Roberto, Bennett, David A, Boehme, Kevin L, Boutros, Paul C, Caberlotto, Laura, Caloian, Cristian, Campbell, Frederick, Chaibub Neto, Elias, Chang, Yu-Chuan, Chen, Beibei, Chen, Chien-Yu, Chien, Ting-Ying, Clark, Tim, Das, Sudeshna, Davatzikos, Christos, Deng, Jieyao, Dillenberger, Donna, Dobson, Richard JB, Dong, Qilin, Doshi, Jimit, Duma, Denise, Errico, Rosangela, Erus, Guray, Everett, Evan, Fardo, David W, Friend, Stephen H, Fröhlich, Holger, Gan, Jessica, St George-Hyslop, Peter, Ghosh, Satrajit S, Glaab, Enrico, Green, Robert C, Guan, Yuanfang, Hong, Ming-Yi, Huang, Chao, Hwang, Jinseub, Ibrahim, Joseph, Inglese, Paolo, Iyappan, Anandhi, Jiang, Qijia, Katsumata, Yuriko, Klein, Arno, Kong, Dehan, Krause, Roland, Lalonde, Emilie, Lauria, Mario, Lee, Eunjee, Lin, Xihui, Liu, Zhandong, Livingstone, Julie, Logsdon, Benjamin A, Lovestone, Simon, Ma, Tsung-wei, Malhotra, Ashutosh, Mangravite, Lara M, Maxwell, Taylor J, Merrill, Emily, Nagorski, John, Namasivayam, Aishwarya, Narayan, Manjari, Naz, Mufassra, Newhouse, Stephen J, Norman, Thea C, Nurtdinov, Ramil N, Oyang, Yen-Jen, Pawitan, Yudi, Peng, Shengwen, Peters, Mette A, Piccolo, Stephen R, Praveen, Paurush, Priami, Corrado, Sabelnykova, Veronica Y, Senger, Philipp, Shen, Xia, Simmons, Andrew, Sotiras, Aristeidis, Stolovitzky, Gustavo, Tangaro, Sabina, Tateo, Andrea, Tung, Yi-An, Tustison, Nicholas J, Varol, Erdem, Vradenburg, George, Weiner, Michael W, Xiao, Guanghua, Xie, Lei, Xie, Yang, Xu, Jia, Yang, Hojin, Zhan, Xiaowei, Zhou, Yunyun, Zhu, Fan, Zhu, Hongtu, Zhu, Shanfeng
Published in Alzheimer's & dementia (01.06.2016)
Published in Alzheimer's & dementia (01.06.2016)
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Leveraging crowdsourcing to facilitate the discovery of new medicines
Norman, Thea C, Bountra, Chas, Edwards, Aled M, Yamamoto, Keith R, Friend, Stephen H
Published in Science translational medicine (22.06.2011)
Published in Science translational medicine (22.06.2011)
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Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer
Margolin, Adam A, Bilal, Erhan, Huang, Erich, Norman, Thea C, Ottestad, Lars, Mecham, Brigham H, Sauerwine, Ben, Kellen, Michael R, Mangravite, Lara M, Furia, Matthew D, Vollan, Hans Kristian Moen, Rueda, Oscar M, Guinney, Justin, Deflaux, Nicole A, Hoff, Bruce, Schildwachter, Xavier, Russnes, Hege G, Park, Daehoon, Vang, Veronica O, Pirtle, Tyler, Youseff, Lamia, Citro, Craig, Curtis, Christina, Kristensen, Vessela N, Hellerstein, Joseph, Friend, Stephen H, Stolovitzky, Gustavo, Aparicio, Samuel, Caldas, Carlos, Børresen-Dale, Anne-Lise
Published in Science translational medicine (17.04.2013)
Published in Science translational medicine (17.04.2013)
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Germline contamination and leakage in whole genome somatic single nucleotide variant detection
Sendorek, Dorota H, Caloian, Cristian, Ellrott, Kyle, Bare, J Christopher, Yamaguchi, Takafumi N, Ewing, Adam D, Houlahan, Kathleen E, Norman, Thea C, Margolin, Adam A, Stuart, Joshua M, Boutros, Paul C
Published in BMC bioinformatics (31.01.2018)
Published in BMC bioinformatics (31.01.2018)
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Journal Article
Global optimization of somatic variant identification in cancer genomes with a global community challenge
Boutros, Paul C, Ewing, Adam D, Ellrott, Kyle, Norman, Thea C, Dang, Kristen K, Hu, Yin, Kellen, Michael R, Suver, Christine, Bare, J Christopher, Stein, Lincoln D, Spellman, Paul T, Stolovitzky, Gustavo, Friend, Stephen H, Margolin, Adam A, Stuart, Joshua M
Published in Nature genetics (01.04.2014)
Published in Nature genetics (01.04.2014)
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Participatory development of a target policy profile to support soil-transmitted helminth elimination
Means, Arianna Rubin, List, Kellie, Roll, Amy, Gwayi-Chore, Marie-Claire, Dolley, Shawn, Schünemann, Holger J, Norman, Thea C, Walson, Judd L
Published in Frontiers in health services (2023)
Published in Frontiers in health services (2023)
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A community challenge to evaluate RNA-seq, fusion detection, and isoform quantification methods for cancer discovery
Creason, Allison, Haan, David, Dang, Kristen, Chiotti, Kami E., Inkman, Matthew, Lamb, Andrew, Yu, Thomas, Hu, Yin, Norman, Thea C., Buchanan, Alex, van Baren, Marijke J., Spangler, Ryan, Rollins, M. Rick, Spellman, Paul T., Rozanov, Dmitri, Zhang, Jin, Maher, Christopher A., Caloian, Cristian, Watson, John D., Uhrig, Sebastian, Haas, Brian J., Jain, Miten, Akeson, Mark, Ahsen, Mehmet Eren, Zhang, Hongjiu, Wang, Yifan, Guan, Yuanfang, Nguyen, Cu, Sugai, Christopher, Jha, Alokkumar, Li, Jing Woei, Dobin, Alexander, Stolovitzky, Gustavo, Guinney, Justin, Boutros, Paul C., Stuart, Joshua M., Ellrott, Kyle
Published in Cell systems (18.08.2021)
Published in Cell systems (18.08.2021)
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A Crowdsourcing Approach to Developing and Assessing Prediction Algorithms for AML Prognosis
Noren, David P, Long, Byron L, Norel, Raquel, Rrhissorrakrai, Kahn, Hess, Kenneth, Hu, Chenyue Wendy, Bisberg, Alex J, Schultz, Andre, Engquist, Erik, Liu, Li, Lin, Xihui, Chen, Gregory M, Xie, Honglei, Hunter, Geoffrey A M, Boutros, Paul C, Stepanov, Oleg, Norman, Thea, Friend, Stephen H, Stolovitzky, Gustavo, Kornblau, Steven, Qutub, Amina A
Published in PLoS computational biology (01.06.2016)
Published in PLoS computational biology (01.06.2016)
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Action for Increasing Diversity, Market Access, and Capacity in Oncology Registration Trials—Is Africa the Answer? Report From a Satellite Session of the Accelerating Anti-Cancer Agent Development and Validation Workshop
Kizub, Darya, Manner, Cathyryne K., Graef, Katy, Abubakar, Bello, Orem, Jackson, Odedina, Folakemi, Adeyeye, Mojisola Christianah, Nakigudde, Gertrude, Ayalew, Kassa, Kalidas, Chitkala, Lyerly, Herbert Kim, Norman, Thea, Fashoyin-Aje, Lola, Freedman, Jamie, Dent, Jennifer, Cance, Bill, Gralow, Julie
Published in JCO global oncology (01.06.2022)
Published in JCO global oncology (01.06.2022)
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Clinical trials in the pandemic age: What is fit for purpose?
Hartman, Dan, Heaton, Penny, Cammack, Nick, Hudson, Ian, Dolley, Shawn, Netsi, Elena, Norman, Thea, Mundel, Trevor
Published in Gates open research (2020)
Published in Gates open research (2020)
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Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors
Gray, Nathanael S., Wodicka, Lisa, Andy-Mark W. H. Thunnissen, Norman, Thea C., Kwon, Soojin, Espinoza, F. Hernan, Morgan, David O., Barnes, Georjana, LeClerc, Sophie, Meijer, Laurent, Kim, Sung-Hou, Lockhart, David J., Schultz, Peter G.
Published in Science (American Association for the Advancement of Science) (24.07.1998)
Published in Science (American Association for the Advancement of Science) (24.07.1998)
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Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains
Madden, Kevin T, Askenazi, Manor, Driggers, Edward M, Holtzman, Douglas A, Norman, Thea C, Iverson, Sara, Zimmer, Daniel P, Boers, Mary-Ellen, Blomquist, Paul R, Martinez, Eduardo J, Monreal, Alex W, Feibelman, Toby P, Mayorga, Maria E, Maxon, Mary E, Sykes, Kristie, Tobin, Jenny Vittum, Cordero, Etchell, Salama, Sofie R, Trueheart, Joshua, Royer, John C
Published in Nature biotechnology (01.02.2003)
Published in Nature biotechnology (01.02.2003)
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