Superiority of [ 11 C]methionine over [ 18 F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer
Kubota, Yutaro, Sato, Toshihiko, Hozumi, Chihiro, Han, Qinghong, Aoki, Yusuke, Masaki, Noriyuki, Obara, Koya, Tsunoda, Takuya, Hoffman, Robert M
Published in International journal of molecular sciences (18.01.2023)
Published in International journal of molecular sciences (18.01.2023)
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Journal Article
Hair follicle associated pluripotent (HAP) stem cells jump from transplanted whiskers to pelage follicles and stimulate hair growth
Obara, Koya, Reynoso, Jose, Hamada, Yuko, Aoki, Yusuke, Kubota, Yutaro, Masaki, Noriyuki, Amoh, Yasuyuki, Hoffman, Robert M.
Published in Scientific reports (07.12.2022)
Published in Scientific reports (07.12.2022)
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Journal Article
Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation
Aoki, Yusuke, Han, Qinghong, Tome, Yasunori, Yamamoto, Jun, Kubota, Yutaro, Masaki, Noriyuki, Obara, Koya, Hamada, Kazuyuki, Wang, Justin D., Inubushi, Sachiko, Bouvet, Michael, Clarke, Steven G., Nishida, Kotaro, Hoffman, Robert M.
Published in Frontiers in oncology (03.11.2022)
Published in Frontiers in oncology (03.11.2022)
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Journal Article
Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models
Aoki, Yusuke, Yamamoto, Jun, Tome, Yasunori, Hamada, Kazuyuki, Masaki, Noriyuki, Inubushi, Sachiko, Tashiro, Yoshihiko, Bouvet, Michael, Endo, Itaru, Nishida, Kotaro, Hoffman, Robert M
Published in Cancer genomics & proteomics (01.11.2021)
Published in Cancer genomics & proteomics (01.11.2021)
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Journal Article
Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation
Aoki, Yusuke, Tome, Yasunori, Han, Qinghong, Yamamoto, Jun, Hamada, Kazuyuki, Masaki, Noriyuki, Bouvet, Michael, Nishida, Kotaro, Hoffman, Robert M.
Published in Biochemistry and biophysics reports (01.12.2021)
Published in Biochemistry and biophysics reports (01.12.2021)
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Journal Article
Development and nationwide validation of kidney graft injury markers using urinary exosomes and microvesicles (complete English translation of the Japanese version)
Harada, Hiroshi, Fukuzawa, Nobuyuki, Abe, Toyofumi, Imamura, Ryoichi, Masaki, Noriyuki, Fujiyama, Nobuhiro, Sato, Shigeru, Hatakeyama, Shingo, Nishimura, Kenji, Kishikawa, Hidefumi, Iwami, Daiki, Hotta, Kiyohiko, Miura, Masayoshi, Ide, Kentaro, Nakamura, Michio, Kosoku, Akihiro, Uchida, Junji, Murakami, Taku, Tsuji, Takahiro
Published in BMC nephrology (06.06.2023)
Published in BMC nephrology (06.06.2023)
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Journal Article
Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease
Kubota, Yutaro, Han, Qinghong, Hozumi, Chihiro, Masaki, Noriyuki, Yamamoto, Jun, Aoki, Yusuke, Tsunoda, Takuya, Hoffman, Robert M
Published in Anticancer research (01.05.2022)
Published in Anticancer research (01.05.2022)
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Journal Article
Loss of Malignancy of Super-Methotrexate-resistant Osteosarcoma Cells Is Associated With an Increase of Methylated Histone Marks H3K9me3 and H3K27me3
Aoki, Yusuke, Kubota, Yutaro, Masaki, Noriyuki, Obara, Koya, Tome, Yasunori, Bouvet, Michael, Nishida, Kotaro, Hoffman, Robert M
Published in Anticancer research (01.10.2024)
Published in Anticancer research (01.10.2024)
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Journal Article
Elimination of Axillary-Lymph-Node Metastases in a Patient With Invasive Lobular Breast Cancer Treated by First-line Neo-adjuvant Chemotherapy Combined With Methionine Restriction
KUBOTA, YUTARO, HAN, QINGHONG, MASAKI, NORIYUKI, HOZUMI, CHIHIRO, HAMADA, KAZUYUKI, AOKI, YUSUKE, OBARA, KOYA, TSUNODA, TAKUYA, HOFFMAN, ROBERT M.
Published in Anticancer research (01.12.2022)
Published in Anticancer research (01.12.2022)
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Journal Article
Reduced Malignancy of Super Methotrexate-resistant Osteosarcoma Cells With Dihydrofolate Reductase Amplification Despite Paradoxical Gain of Oncogenic PI3K/AKT/mTOR and c-MYC expression
Aoki, Yusuke, Kubota, Yutaro, Masaki, Noriyuki, Obara, Koya, Tome, Yasunori, Bouvet, Michael, Nishida, Kotaro, Hoffman, Robert M
Published in Anticancer research (01.07.2024)
Published in Anticancer research (01.07.2024)
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Journal Article
Methionine restriction of glioma does not induce MGMT and greatly improves temozolomide efficacy in an orthotopic nude-mouse model: A potential curable approach to a clinically-incurable disease
Kubota, Yutaro, Aoki, Yusuke, Masaki, Noriyuki, Obara, Koya, Hamada, Kazuyuki, Han, Qinghong, Bouvet, Michael, Tsunoda, Takuya, Hoffman, Robert M
Published in Biochemical and biophysical research communications (05.02.2024)
Published in Biochemical and biophysical research communications (05.02.2024)
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Journal Article
Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model
Aoki, Yusuke, Tome, Yasunori, Han, Qinghong, Yamamoto, Jun, Hamada, Kazuyuki, Masaki, Noriyuki, Kubota, Yutaro, Bouvet, Michael, Nishida, Kotaro, Hoffman, Robert M
Published in Anticancer research (01.02.2022)
Published in Anticancer research (01.02.2022)
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Journal Article
Chloroquine Combined With Rapamycin Arrests Tumor Growth in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Dedifferentiated Liposarcoma
Masaki, Noriyuki, Aoki, Yusuke, Kubota, Yutaro, Obara, Koya, Miyazaki, Jun, Hoffman, Robert M
Published in In vivo (Athens) (01.11.2022)
Published in In vivo (Athens) (01.11.2022)
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Journal Article
Oral-recombinant Methioninase in Combination With Rapamycin Eradicates Osteosarcoma of the Breast in a Patient-derived Orthotopic Xenograft Mouse Model
MASAKI, NORIYUKI, HAN, QINGHONG, SAMONTE, CARISSA, WU, NATHANIEL F., HOZUMI, CHIHIRO, WU, JUSTIN, OBARA, KOYA, KUBOTA, YUTARO, AOKI, YUSUKE, BOUVET, MICHAEL, HOFFMAN, ROBERT M.
Published in Anticancer research (01.11.2022)
Published in Anticancer research (01.11.2022)
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Journal Article
Meckel's Diverticulum Carcinoma Is Arrested by Oxaliplatinum and Eradicated by 5-Fluorouracil in a PDX Mouse Model Indicating Candidate First-line Treatment for a Rare Cancer
Masaki, Noriyuki, Yonemura, Yutaka, Hozumi, Chihiro, Obara, Koya, Kubota, Yutaro, Aoki, Yusuke, Hoffman, Robert M
Published in In vivo (Athens) (01.07.2023)
Published in In vivo (Athens) (01.07.2023)
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Journal Article
Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice
Kubota, Yutaro, Han, Qinghong, Reynoso, Jose, Aoki, Yusuke, Masaki, Noriyuki, Obara, Koya, Hamada, Kazuyuki, Bouvet, Michael, Tsunoda, Takuya, Hoffman, Robert M
Published in Aging (Albany, NY.) (09.06.2023)
Published in Aging (Albany, NY.) (09.06.2023)
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Journal Article
Long-term Stable Disease in a Rectal-cancer Patient Treated by Methionine Restriction With Oral Recombinant Methioninase and a Low-methionine Diet
KUBOTA, YUTARO, HAN, QINGHONG, HAMADA, KAZUYUKI, AOKI, YUSUKE, MASAKI, NORIYUKI, OBARA, KOYA, TSUNODA, TAKUYA, HOFFMAN, ROBERT M.
Published in Anticancer research (01.08.2022)
Published in Anticancer research (01.08.2022)
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Journal Article
Targeting Autophagy With the Synergistic Combination of Chloroquine and Rapamycin as a Novel Effective Treatment for Well-differentiated Liposarcoma
Masaki, Noriyuki, Aoki, Yusuke, Obara, Koya, Kubota, Yutaro, Bouvet, Michael, Miyazaki, Jun, Hoffman, Robert M
Published in Cancer genomics & proteomics (01.07.2023)
Published in Cancer genomics & proteomics (01.07.2023)
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Journal Article
Non-invasively Imageable Tibia-tumor-fragment Implantation Experimental-bone-metastasis Mouse Model of GFP-expressing Prostate Cancer
AOKI, YUSUKE, MASAKI, NORIYUKI, TOME, YASUNORI, KUBOTA, YUTARO, AOKI, YASUYO, BOUVET, MICHAEL, NISHIDA, KOTARO, HOFFMAN, ROBERT M.
Published in In vivo (Athens) (01.07.2022)
Published in In vivo (Athens) (01.07.2022)
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Journal Article