Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma
Bernasconi, Elena, Gaudio, Eugenio, Lejeune, Pascale, Tarantelli, Chiara, Cascione, Luciano, Kwee, Ivo, Spriano, Filippo, Rinaldi, Andrea, Mensah, Afua A., Chung, Elaine, Stathis, Anastasios, Siegel, Stephan, Schmees, Norbert, Ocker, Matthias, Zucca, Emanuele, Haendler, Bernard, Bertoni, Francesco
Published in British journal of haematology (01.09.2017)
Published in British journal of haematology (01.09.2017)
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Journal Article
Dissociation of Transactivation from Transrepression by a Selective Glucocorticoid Receptor Agonist Leads to Separation of Therapeutic Effects from Side Effects
Schäcke, Heike, Schottelius, Arndt, Döcke, Wolf-Dietrich, Strehlke, Peter, Jaroch, Stefan, Schmees, Norbert, Rehwinkel, Hartmut, Hennekes, Hartwig, Asadullah, Khusru
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2004)
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Journal Article
Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy
Kober, Christina, Roewe, Julian, Schmees, Norbert, Roese, Lars, Roehn, Ulrike, Bader, Benjamin, Stoeckigt, Detlef, Prinz, Florian, Gorjánácz, Mátyás, Roider, Helge Gottfried, Olesch, Catherine, Leder, Gabriele, Irlbacher, Horst, Lesche, Ralf, Lefranc, Julien, Oezcan-Wahlbrink, Mine, Batra, Ankita Sati, Elmadany, Nirmeen, Carretero, Rafael, Sahm, Katharina, Oezen, Iris, Cichon, Frederik, Baumann, Daniel, Sadik, Ahmed, Opitz, Christiane A, Weinmann, Hilmar, Hartung, Ingo V, Kreft, Bertolt, Offringa, Rienk, Platten, Michael, Gutcher, Ilona
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
926 BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy
Offringa, Rienk, Olesch, Catherine, Cichon, Frederik, Grees, Mareike, Schmees, Norbert, Roehn, Ulrike, Prinz, Florian, Stoeckigt, Detlef, Erkelenz, Michael, Uyen Nguyen, Thi Thanh, Boemer, Ulf, Günther, Judith, Kunze, Marc, Petersen, Kirstin, Kirchhoff, Dennis
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Enantioselective Heck reactions using chiral P,N-ligands
Loiseleur, Olivier, Hayashi, Masahiko, Keenan, Martine, Schmees, Norbert, Pfaltz, Andreas
Published in Journal of Organometallic Chemistry (15.03.1999)
Published in Journal of Organometallic Chemistry (15.03.1999)
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Book Review
Journal Article
Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1
Jung, Marie, Philpott, Martin, Müller, Susanne, Schulze, Jessica, Badock, Volker, Eberspächer, Uwe, Moosmayer, Dieter, Bader, Benjamin, Schmees, Norbert, Fernández-Montalván, Amaury, Haendler, Bernard
Published in The Journal of biological chemistry (28.03.2014)
Published in The Journal of biological chemistry (28.03.2014)
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Journal Article
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21
Göricke, Fabian, Vu, Victoria, Smith, Leanna, Scheib, Ulrike, Böhm, Raphael, Akkilic, Namik, Wohlfahrt, Gerd, Weiske, Jörg, Bömer, Ulf, Brzezinka, Krzysztof, Lindner, Niels, Lienau, Philip, Gradl, Stefan, Beck, Hartmut, Brown, Peter J., Santhakumar, Vijayaratnam, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Schmees, Norbert, Petersen, Kirstin
Published in Journal of medicinal chemistry (09.03.2023)
Published in Journal of medicinal chemistry (09.03.2023)
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Journal Article
Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women
Panknin, Olaf, Wagenfeld, Andrea, Bone, Wilhelm, Bender, Eckhard, Nowak-Reppel, Katrin, Fernández-Montalván, Amaury E, Nubbemeyer, Reinhard, Bäurle, Stefan, Ring, Sven, Schmees, Norbert, Prien, Olaf, Schäfer, Martina, Friedrich, Christian, Zollner, Thomas M, Steinmeyer, Andreas, Mueller, Thomas, Langer, Gernot
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Journal Article
Discovery of new selective glucocorticoid receptor agonist leads
Berger, Markus, Rehwinkel, Hartmut, Schmees, Norbert, Schäcke, Heike, Edman, Karl, Wissler, Lisa, Reichel, Andreas, Jaroch, Stefan
Published in Bioorganic & medicinal chemistry letters (01.02.2017)
Published in Bioorganic & medicinal chemistry letters (01.02.2017)
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Journal Article
Abstract 1288: Blocking tumor-associated immune suppression with BAY-218, a novel, selective aryl hydrocarbon receptor (AhR) inhibitor
Gutcher, Ilona, Kober, Christina, Roese, Lars, Roewe, Julian, Schmees, Norbert, Prinz, Florian, Gorjanacz, Matyas, Roehn, Ulrike, Bader, Benjamin, Irlbacher, Horst, Stoeckigt, Detlef, Carretero, Rafael, Sahm, Katharina, Oezen, Iris, Weinmann, Hilmar, Hartung, Ingo V., Kreft, Bertolt, Platten, Michael
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 4454: Identification of BAY-218, a potent and selective small-molecule AhR inhibitor, as a new modality to counteract tumor immunosuppression
Schmees, Norbert, Gutcher, Ilona, Roehn, Ulrike, Irlbacher, Horst, Stoeckigt, Detlef, Bader, Benjamin, Kober, Christina, Roese, Lars, Carretero, Rafael, Oezen, Iris, Zorn, Ludiwg, Platten, Michael, Hartung, Ingo Volker, Kreft, Bertolt, Weinmann, Hilmar
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
SUBSTITUTED AMINOQUINOLONES AS DGK ALPHA INHIBITORS FOR IMMUNE ACTIVATION
CHRISTIAN LECHNER, DIRK KOSEMUND, DETLEF STOECKIGT, NICOLAS WERBECK, NGUYEN THI THANH UYEN, SIMON ANTHONY HERBERT, CHRISTINA KOBER, DENNIS KIRCHHOFF, KIRSTIN PETERSEN, MAREIKE GREES, NORBERT SCHMEES, ISABEL PATRIZIA KERSCHGENS, LARS WORTMANN, BENJAMIN BADER, RIENK OFFRINGA, ROBIN MICHAEL MEIER, ULF BOEMER
Year of Publication 25.07.2024
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Year of Publication 25.07.2024
Patent
Abstract ND04: BAY 2965501: A highly selective DGK- ζ inhibitor for cancer immuno-therapy with first-in-class potential
Offringa, Rienk, Olesch, Catherine, Cichon, Frederik, Grees, Mareike, Schmees, Norbert, Roehn, Ulrike, Prinz, Florian, Guenther, Judith, Stoeckigt, Detlef, Erkelenz, Michael, Nguyen, Thi Thanh Uyen, Boemer, Ulf, Werbeck, Nicolas, Kunze, Marc, Petersen, Kirstin, Kirchhoff, Dennis
Published in Cancer research (Chicago, Ill.) (29.05.2023)
Published in Cancer research (Chicago, Ill.) (29.05.2023)
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Journal Article
Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor
Gradl, Stefan, Steuber, Holger, Weiske, Jörg, Schmees, Norbert, Siegel, Stephan, Stoeckigt, Detlef, Christ, Clara D., Li, Fengling, Organ, Shawna, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena M., Kennedy, Steven, Trush, Viacheslav, Vedadi, Masoud, Arrowsmith, Cheryl H., Brown, Peter J., Husemann, Manfred, Fernandez-Montalvan, Amaury E., Badock, Volker, Bauser, Marcus, Haegebarth, Andrea, Hartung, Ingo V., Stresemann, Carlo
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 4749: New benzazepine BET-inhibitors with improved oral bioavailability
Schmees, Norbert, Haendler, Bernard, Lejeune, Pascale, Stresemann, Antje, Neuhaus, Roland, Siegel, Stephan, Fernandez-Montalvan, Amaury Ernesto, Weinmann, Hilmar, Gekeler, Volker
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening
Gradl, Stefan, Steuber, Holger, Weiske, Joerg, Szewczyk, Magda M., Schmees, Norbert, Siegel, Stephan, Stoeckigt, Detlef, Christ, Clara D., Li, Fengling, Organ, Shawna, Abbey, Megha, Kennedy, Steven, Chau, Irene, Trush, Viacheslav, Barsyte-Lovejoy, Dalia, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl, Husemann, Manfred, Badock, Volker, Bauser, Marcus, Haegebarth, Andrea, Hartung, Ingo V., Stresemann, Carlo
Published in SLAS discovery (01.09.2021)
Published in SLAS discovery (01.09.2021)
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Journal Article
Abstract 3524: BAY 1238097, a novel BET inhibitor with strong efficacy in hematological tumor models
Lejeune, Pascale, Sugawara, Tatsuo, Gelato, Kathy A., Ellinger-Ziegelbauer, Heidrun, Fernandez-Montalvan, Amaury E., Schmees, Norbert, Siegel, Stephan, Weinmann, Hilmar, Gekeler, Volker, Walter, Annette O., Ocker, Matthias, Ince, Stuart, Haendler, Bernard
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Discovery of quinolines as selective glucocorticoid receptor agonists
Jaroch, Stefan, Berger, Markus, Huwe, Christoph, Krolikiewicz, Konrad, Rehwinkel, Hartmut, Schäcke, Heike, Schmees, Norbert, Skuballa, Werner
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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Journal Article