Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol
Kempf, Dale J, Codacovi, Lynnmarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C, Bryant, Pamela
Published in Journal of medicinal chemistry (01.02.1993)
Published in Journal of medicinal chemistry (01.02.1993)
Get full text
Journal Article
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
Molla, A, Korneyeva, M, Gao, Q, Vasavanonda, S, Schipper, P J, Mo, H M, Markowitz, M, Chernyavskiy, T, Niu, P, Lyons, N, Hsu, A, Granneman, G R, Ho, D D, Boucher, C A, Leonard, J M, Norbeck, D W, Kempf, D J
Published in Nature medicine (01.07.1996)
Published in Nature medicine (01.07.1996)
Get more information
Journal Article
Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir
KEMPF, D. J, MARSH, K. C, SUN, E, PIZZUTI, D, PLATTNER, J. J, NORBECK, D. W, LEONARD, J. M, KUMAR, G, RODRIGUES, A. D, DENISSEN, J. F, MCDONALD, E, KUKULKA, M. J, HSU, A, GRANNEMAN, G. R, BAROLDI, P. A
Published in Antimicrobial Agents and Chemotherapy (01.03.1997)
Published in Antimicrobial Agents and Chemotherapy (01.03.1997)
Get full text
Journal Article
ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans
Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.1995)
Get full text
Journal Article
Human Serum Attenuates the Activity of Protease Inhibitors toward Wild-Type and Mutant Human Immunodeficiency Virus
Molla, Akhteruzzaman, Vasavanonda, Sudthida, Kumar, Gondi, Sham, Hing L., Johnson, Marianne, Grabowski, Brian, Denissen, Jon F., Kohlbrenner, William, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W., Kempf, Dale J.
Published in Virology (New York, N.Y.) (25.10.1998)
Published in Virology (New York, N.Y.) (25.10.1998)
Get full text
Journal Article
In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants with Increased Resistance to ABT-378, a Novel Protease Inhibitor
Carrillo, A, Stewart, K D, Sham, H L, Norbeck, D W, Kohlbrenner, W E, Leonard, J M, Kempf, D J, Molla, A
Published in Journal of Virology (01.09.1998)
Published in Journal of Virology (01.09.1998)
Get full text
Journal Article
X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease
STOLL, Vincent, WENYING QIN, KEMPF, Dale, SHAM, Hing L, NORBECK, Daniel W, STEWART, Kent D, JAKOB, Clarissa, CHANG PARK, WALTER, K, SIMMER, R. L, HELFRICH, Rosalind, BUSSIERE, Dirk, KAO, J
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
Get full text
Journal Article
Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy
Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
Get full text
Journal Article
Novel lopinavir analogues incorporating non-Aromatic P-1 side chains—Synthesis and structure–Activity relationships
Sham, Hing L, Zhao, Chen, Li, Leping, Betebenner, David A, Saldivar, Ayda, Vasavanonda, Sudthida, Kempf, Dale J, Plattner, Jacob J, Norbeck, Daniel W
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Get full text
Journal Article
Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase
KATI, Warren M, MONTGOMERY, Debra, MARING, Clarence, STOLL, Vincent S, GIRANDA, Vincent, XIAOQI CHEN, LAVER, W. Graeme, KOHLBRENNER, William, NORBECK, Daniel W
Published in Antimicrobial Agents and Chemotherapy (01.09.2001)
Published in Antimicrobial Agents and Chemotherapy (01.09.2001)
Get full text
Journal Article
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains
Zhao, Chen, Sham, Hing L., Sun, Minghua, Stoll, Vincent S., Stewart, Kent D., Lin, Shuqun, Mo, Hongmei, Vasavanonda, Sudthida, Saldivar, Ayda, Park, Chang, McDonald, Edith J., Marsh, Kennan C., Klein, Larry L., Kempf, Dale J., Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
Get full text
Journal Article
Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
Erickson, J, Neidhart, D J, VanDrie, J, Kempf, D J, Wang, X C, Norbeck, D W, Plattner, J J, Rittenhouse, J W, Turon, M, Wideburg, N
Published in Science (American Association for the Advancement of Science) (03.08.1990)
Published in Science (American Association for the Advancement of Science) (03.08.1990)
Get full text
Journal Article
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles
KAPLAN, A. H, ZACK, J. A, KNIGGE, M, PAUL, D. A, KEMPF, D. J, NORBECK, D. W, SWANSTROM, R
Published in Journal of Virology (01.07.1993)
Published in Journal of Virology (01.07.1993)
Get full text
Journal Article
Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea––synthesis and structure–activity relationships
Sham, Hing L., Betebenner, David A., Rosenbrook, William, Herrin, Thomas, Saldivar, Ayda, Vasavanonda, Sudthida, Plattner, Jacob J., Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
Get full text
Journal Article
Selection of Multiple Human Immunodeficiency Virus Type 1 Variants that Encode Viral Proteases with Decreased Sensitivity to an Inhibitor of the Viral Protease
Kaplan, Andrew H., Michael, Scott F., Wehbie, Robert S., Knigge, Mark F., Paul, Deborah A., Everitt, Lorraine, Kempf, Dale J., Norbeck, Daniel W., Erickson, John W., Swanstrom, Ronald
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.1994)
Get full text
Journal Article
Genotypic Changes in Human Immunodeficiency Virus Type 1 Associated with Loss of Suppression of Plasma Viral RNA Levels in Subjects Treated with Ritonavir (Norvir) Monotherapy
Eastman, P S, Mittler, J, Kelso, R, Gee, C, Boyer, E, Kolberg, J, Urdea, M, Leonard, J M, Norbeck, D W, Mo, H, Markowitz, M
Published in Journal of Virology (01.06.1998)
Published in Journal of Virology (01.06.1998)
Get full text
Journal Article
Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P 2 ligands
Chen, Xiaoqi, Kempf, Dale J., Li, Lin, Sham, Hing L., Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (01.11.2003)
Published in Bioorganic & medicinal chemistry letters (01.11.2003)
Get full text
Journal Article
Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)
SHAM, Hing L, BETEBENNER, David A, XIAOQI CHEN, SALDIVAR, Ayda, VASAVANONDA, Sudthida, KEMPF, Dale J, PLATTNER, Jacob J, NORBECK, Daniel W
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
Get full text
Journal Article
A novel, picomolar inhibitor of human immunodeficiency virus type 1 proteases
Sham, HL, Zhao, C, Stewart, KD, Betebenner, DA, Lin, SQ, Park, CH, Kong, XP, Rosenbrook, W, Herrin, T, Madigan, D, Vasavanonda, S, Lyons, N, Molla, A, Saldivar, A, Marsh, KC, McDonald, E, Wideburg, NE, Denissen, JF, Robins, T, Kempf, DJ, Plattner, JJ, Norbeck, DW
Published in Journal of medicinal chemistry (19.01.1996)
Published in Journal of medicinal chemistry (19.01.1996)
Get full text
Journal Article