Phagocytosis by human monocytes is required for the secretion of presepsin
Arai, Yasuyuki, Mizugishi, Kiyomi, Nonomura, Kazuhiko, Naitoh, Katsuki, Takaori-Kondo, Akifumi, Yamashita, Kouhei
Published in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (01.08.2015)
Published in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (01.08.2015)
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Journal Article
Insulin down-regulates specific activity of ATP-binding cassette transporter A1 for high density lipoprotein biogenesis through its specific phosphorylation
Nonomura, Kazuhiko, Arai, Yoshie, Mitani, Hironobu, Abe-Dohmae, Sumiko, Yokoyama, Shinji
Published in Atherosclerosis (01.06.2011)
Published in Atherosclerosis (01.06.2011)
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Journal Article
Hurdles in the drug discovery of cathepsin K inhibitors
Kometani, Motohiko, Nonomura, Kazuhiko, Tomoo, Takashi, Niwa, Satoru
Published in Current topics in medicinal chemistry (01.05.2010)
Published in Current topics in medicinal chemistry (01.05.2010)
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Journal Article
Effect of Cathepsin K Inhibitors on Bone Resorption
Teno, Naoki, Masuya, Keiichi, Ehara, Takeru, Kosaka, Takatoshi, Miyake, Takahiro, Irie, Osamu, Hitomi, Yuko, Matsuura, Naoko, Umemura, Ichiro, Iwasaki, Genji, Fukaya, Hiroaki, Toriyama, Kazuhiro, Uchiyama, Noriko, Nonomura, Kazuhiko, Sugiyama, Ikuo, Kometani, Motohiko
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
Comparison of Heat- and Pressure-Induced Unfolding of Ribonuclease A: The Critical Role of Phe46 Which Appears To Belong to a New Hydrophobic Chain-Folding Initiation Site
Chatani, Eri, Nonomura, Kazuhiko, Hayashi, Rikimaru, Balny, Claude, Lange, Reinhard
Published in Biochemistry (Easton) (09.04.2002)
Published in Biochemistry (Easton) (09.04.2002)
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Journal Article
Preservation of Endothelial Function by the HMG-CoA Reductase Inhibitor Fluvastatin through Its Lipid-Lowering Independent Antioxidant Properties in Atherosclerotic Rabbits
Mitani, Hironobu, Egashira, Kensuke, Ohashi, Noriko, Yoshikawa, Masayoshi, Niwa, Satoru, Nonomura, Kazuhiko, Nakashima, Akinori, Kimura, Masaaki
Published in Pharmacology (01.07.2003)
Published in Pharmacology (01.07.2003)
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Journal Article
Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma
Yamada, Ken, Brousseau, Margaret, Honma, Wataru, Iimura, Akiko, Imase, Hidetomo, Iwaki, Yuki, Kawanami, Toshio, LaSala, Daniel, Liang, Guiqing, Mitani, Hironobu, Nonomura, Kazuhiko, Ohmori, Osamu, Pan, Meihui, Rigel, Dean F, Umemura, Ichiro, Yasoshima, Kayo, Zhu, Guoming, Mogi, Muneto
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Journal Article
Abstract 2845: Prostaglandin E receptor EP4 antagonist RQ00015986 inhibits breast cancer metastasis and protects natural killer cells from PGE-mediated immune suppression
Ma, Xinrong, Holt, Dawn, Kundu, Namita, Nonomura, Kazuhiko, Take, Yukinori, Fulton, Amy M.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 893: Anticancer effect and mechanism of prostaglandin E2 receptor EP4 antagonist
Nonomura, Kazuhiko, Miyama, Katsuyoshi, Kanazawa, Kiyoshi, Okumura, Takako, Okumura, Yoshiyuki, Oshima, Masanobu, Takahashi, Satoru, Take, Yukinori
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
USES OF EP4 RECEPTOR ANTAGONIST FOR TREATING IL-23 MEDIATED DISEASES
NONOMURA KAZUHIKO, KANAZAWA KIYOSHI, OKUMURA TAKAKO, KOIZUMI SHINICHI
Year of Publication 01.06.2017
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Year of Publication 01.06.2017
Patent
METHOD OF TREATING ATHEROSCLEROSIS IN HIGH TRIGLYCERIDE SUBJECTS
GU JESSIE, MOGI MUNETO, HAYASHI TOMOKO, ARAI YOSHIE, NONOMURA KAZUHIKO, MITANI HIRONOBU, BROUSSEAU MARGARET ELIZABETH, YAMADA KEN
Year of Publication 11.03.2019
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Year of Publication 11.03.2019
Patent
Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain
Irie, Osamu, Kosaka, Takatoshi, Ehara, Takeru, Yokokawa, Fumiaki, Kanazawa, Takanori, Hirao, Hajime, Iwasaki, Astuko, Sakaki, Junichi, Teno, Naoki, Hitomi, Yuko, Iwasaki, Genji, Fukaya, Hiroaki, Nonomura, Kazuhiko, Tanabe, Keiko, Koizumi, Shinichi, Uchiyama, Noriko, Bevan, Stuart J, Malcangio, Marzia, Gentry, Clive, Fox, Alyson J, Yaqoob, Mohammed, Culshaw, Andrew J, Hallett, Allan
Published in Journal of medicinal chemistry (25.09.2008)
Published in Journal of medicinal chemistry (25.09.2008)
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Journal Article
New chemotypes for cathepsin K inhibitors
Teno, Naoki, Irie, Osamu, Miyake, Takahiro, Gohda, Keigo, Horiuchi, Miyuki, Tada, Sachiyo, Nonomura, Kazuhiko, Kometani, Motohiko, Iwasaki, Genji, Betschart, Claudia
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Journal Article
Novel scaffold for cathepsin K inhibitors
Teno, Naoki, Miyake, Takahiro, Ehara, Takeru, Irie, Osamu, Sakaki, Junichi, Ohmori, Osamu, Gunji, Hiroki, Matsuura, Naoko, Masuya, Keiichi, Hitomi, Yuko, Nonomura, Kazuhiko, Horiuchi, Miyuki, Gohda, Keigo, Iwasaki, Atsuko, Umemura, Ichiro, Tada, Sachiyo, Kometani, Motohiko, Iwasaki, Genji, Cowan-Jacob, Sandra W., Missbach, Martin, Lattmann, René, Betschart, Claudia
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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Journal Article
METHOD OF TREATING ATHEROSCLEROSIS IN HIGH TRIGLYCERIDE SUBJECTS
GU JESSIE, HAYASHI TOMOKO, ARAI YOSHIE, MOGI MUNEHITO, YAMADA TAKESHI, NONOMURA KAZUHIKO, MITANI HIRONOBU, MARGARET ELIZABETH BROUSSEAU
Year of Publication 18.05.2017
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Year of Publication 18.05.2017
Patent