The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer
Deegen, Petra, Thomas, Oliver, Nolan-Stevaux, Olivier, Li, Shyun, Wahl, Joachim, Bogner, Pamela, Aeffner, Famke, Friedrich, Matthias, Liao, Michael Z, Matthes, Katja, Rau, Doris, Rattel, Benno, Raum, Tobias, Kufer, Peter, Coxon, Angela, Bailis, Julie M
Published in Clinical cancer research (15.05.2021)
Published in Clinical cancer research (15.05.2021)
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Journal Article
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
Nolan-Stevaux, Olivier, Lau, Janet, Truitt, Morgan L, Chu, Gerald C, Hebrok, Matthias, Fernández-Zapico, Martin E, Hanahan, Douglas
Published in Genes & development (01.01.2009)
Published in Genes & development (01.01.2009)
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Journal Article
Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies
Nolan-Stevaux, Olivier, Zhong, Wendy, Culp, Stacey, Shaffer, Kathy, Hoover, Joseph, Wickramasinghe, Dineli, Ruefli-Brasse, Astrid
Published in PloS one (27.12.2012)
Published in PloS one (27.12.2012)
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Journal Article
Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma
Olson, Peter, Chu, Gerald C, Perry, Samuel R, Nolan-Stevaux, Olivier, Hanahan, Douglas
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
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Journal Article
Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway
Shen, Ye, Eng, Jason S, Fajardo, Flordeliza, Liang, Lingming, Li, Cong, Collins, Patrick, Tedesco, Donato, Nolan-Stevaux, Olivier
Published in Journal for immunotherapy of cancer (01.03.2022)
Published in Journal for immunotherapy of cancer (01.03.2022)
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Journal Article
Measurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor Engraftment
Nolan-Stevaux, Olivier, Tedesco, Donato, Ragan, Seamus, Makhanov, Mikhail, Chenchik, Alex, Ruefli-Brasse, Astrid, Quon, Kim, Kassner, Paul D
Published in PloS one (26.06.2013)
Published in PloS one (26.06.2013)
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Journal Article
718 AMG 509, a STEAP1 x CD3 bispecific XmAb® 2+1 immune therapy, exhibits avidity-driven binding and preferential killing of high STEAP1-expressing prostate and Ewing sarcoma cancer cells
Li, Cong, Fort, Madeline, Liang, Lingming, Moore, Gregory, Bernett, Matthew, Muchhal, Umesh, Osgood, Tao, Yabut, Rodolfo, Kaliyaperumal, Sarav, Harrold, John, Canon, Jude, Rogojina, Anna, Kurmasheva, Raushan, Desjarlais, John, Houghton, Peter, Nolan-Stevaux, Olivier
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
항-CCR8 항체 및 이의 용도
RAUM TOBIAS, KIELCZEWSKA AGNIESZKA, BATES DARREN L, HONER JONAS KARL JOSEF, PIERCE NATHAN WILLIAM, WINKEL LISA, NOLAN STEVAUX OLIVIER, BLUEMEL CLAUDIA, DAHLHOFF CHRISTOPH, CHEN WENTAO
Year of Publication 08.02.2024
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Year of Publication 08.02.2024
Patent
항-STEAP1 항원 결합 단백질
ALBA BENJAMIN M, GRAHAM KEVIN, STEVENS JENNITTE LEANN, MOORE GREGORY, NOLAN STEVAUX OLIVIER, LI CONG, MURAWSKY CHRISTOPHER M, AGRAMAL NEERAJ JAGDISH
Year of Publication 11.03.2021
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Year of Publication 11.03.2021
Patent
CD70 및 CD3에 대한 항체 구조체
RAUM TOBIAS, LUTTERBUESE RALF, HOFFMANN PATRICK, BLUEMEL CLAUDIA, PANZER MARC, NOLAN STEVAUX OLIVIER, NAHRWOLD ELISABETH, DEISTING WIBKE
Year of Publication 13.04.2018
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Year of Publication 13.04.2018
Patent
Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release
Zuch de Zafra, Christina L, Fajardo, Flordeliza, Zhong, Wendy, Bernett, Matthew J, Muchhal, Umesh S, Moore, Gregory L, Stevens, Jennitte, Case, Ryan, Pearson, Joshua T, Liu, Siyuan, McElroy, Patricia L, Canon, Jude, Desjarlais, John R, Coxon, Angela, Balazs, Mercedesz, Nolan-Stevaux, Olivier
Published in Clinical cancer research (01.07.2019)
Published in Clinical cancer research (01.07.2019)
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Journal Article
Abstract 6714: Genetic screens identify T cell co-stimulation as a key modifier of the redirected cytotoxicity of bispecific T cell engager (BiTE®) molecules
Shen, Ye, Collins, Patrick, Eng, Jason, Fajardo, Flordeliza, Zhong, Wendy, Nolan-Stevaux, Olivier
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys
Harper, Tod, Sharma, Amy, Kaliyaperumal, Sarav, Fajardo, Flordeliza, Hsu, Katie, Liu, Lily, Davies, Rhian, Wei, Yu-Ling, Zhan, Jinghui, Estrada, Juan, Kvesic, Majk, Nahrwold, Lisa, Deisting, Wibke, Panzer, Marc, Cooke, Keegan, Lebrec, Hervé, Nolan-Stevaux, Olivier
Published in Toxicological sciences (25.08.2022)
Published in Toxicological sciences (25.08.2022)
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Journal Article
AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Nolan-Stevaux, Olivier, Li, Cong, Liang, Lingming, Zhan, Jinghui, Estrada, Juan, Osgood, Tao, Li, Fei, Zhang, Hanzhi, Case, Ryan, Murawsky, Christopher M, Estes, Bram, Moore, Gregory L, Bernett, Matthew J, Muchhal, Umesh, Desjarlais, John R, Staley, Binnaz K, Stevens, Jennitte, Cooke, Keegan S, Aeffner, Famke, Thomas, Oliver, Stieglmaier, Julia, Lee, Jae-Lyun, Coxon, Angela, Bailis, Julie M
Published in Cancer discovery (12.01.2024)
Published in Cancer discovery (12.01.2024)
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Journal Article
Abstract 585: Assessing ENPP3 as a renal cancer target for bispecific T-cell engager (BiTE) therapy
Nolan-Stevaux, Olivier, Fajardo, Flordeliza, Liu, Lily, Coberly, Suzanne, McElroy, Patricia, Nazarian, Aaron, Bott, Franziska, Nahrwold, Elisabeth, Raum, Tobias, Kischel, Roman, Lutterbuese, Ralf, Hoffmann, Patrick, Kufer, Peter
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Preclinical Characterization of AMG 424, a Novel Humanized T Cell-Recruiting Bispecific Anti-CD3/CD38 Antibody
de Zafra, Christina, Balazs, Mercedesz, Fajardo, Flordeliza, Liang, Lingming, Zhong, Wendy, Henn, Anja, Bernett, Matthew J., Moore, Gregory, Muchhal, Umesh, Winters, Dwight, Frank, Brendon, Cook, Kevin, Pearson, Josh, Melhem, Murad, Petrovic, Vladimir, Pelham, Robert J., Friedrich, Matthias, Tan, Hong, Moody, Gordon, Stevens, Jenitte, Desjarlais, John, Coxon, Angela, Nolan-Stevaux, Olivier
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Abstract 4548: High throughput siRNA screens uncover a high rate of USP8 and ESCRT pathway dependency in squamous carcinoma cell lines
Zhong, Wendy, Cosgrove, Elissa, Swearingen, Elissa, Ollmann, Mike, Banerjee, Jayee, Watson, Vivienne, Jaeckel, Peter, Pfreimer, Mariana, Materna-Reichelt, Silvia, Beckmann, Holger, Kassner, Paul, Ruefli-Brasse, Astrid, Nolan-Stevaux, Olivier
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 5079: Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-Endoglin antibodies
Nolan-Stevaux, Olivier P., Zhong, Wendy, Wickramasinghe, Dineli, Ruefli-Brasse, Astrid
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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