Discovery of 1H‑Pyrazol-3(2H)‑ones as Potent and Selective Inhibitors of Protein Kinase R‑like Endoplasmic Reticulum Kinase (PERK)
Smith, Adrian L, Andrews, Kristin L, Beckmann, Holger, Bellon, Steven F, Beltran, Pedro J, Booker, Shon, Chen, Hao, Chung, Young-Ah, D’Angelo, Noel D, Dao, Jennifer, Dellamaggiore, Kenneth R, Jaeckel, Peter, Kendall, Richard, Labitzke, Katja, Long, Alexander M, Materna-Reichelt, Silvia, Mitchell, Petia, Norman, Mark H, Powers, David, Rose, Mark, Shaffer, Paul L, Wu, Michelle M, Lipford, J. Russell
Published in Journal of medicinal chemistry (12.02.2015)
Published in Journal of medicinal chemistry (12.02.2015)
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Journal Article
Structure-Based Design of Novel Class II c-Met Inhibitors: 1. Identification of Pyrazolone-Based Derivatives
Norman, Mark H, Liu, Longbin, Lee, Matthew, Xi, Ning, Fellows, Ingrid, D’Angelo, Noel D, Dominguez, Celia, Rex, Karen, Bellon, Steven F, Kim, Tae-Seong, Dussault, Isabelle
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Journal Article
Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series
Liu, Longbin, Norman, Mark H, Lee, Matthew, Xi, Ning, Siegmund, Aaron, Boezio, Alessandro A, Booker, Shon, Choquette, Debbie, D’Angelo, Noel D, Germain, Julie, Yang, Kevin, Yang, Yajing, Zhang, Yihong, Bellon, Steven F, Whittington, Douglas A, Harmange, Jean-Christophe, Dominguez, Celia, Kim, Tae-Seong, Dussault, Isabelle
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Journal Article
Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors
D’Angelo, Noel D, Kim, Tae-Seong, Andrews, Kristin, Booker, Shon K, Caenepeel, Sean, Chen, Kui, D’Amico, Derin, Freeman, Dan, Jiang, Jian, Liu, Longbin, McCarter, John D, San Miguel, Tisha, Mullady, Erin L, Schrag, Michael, Subramanian, Raju, Tang, Jin, Wahl, Robert C, Wang, Ling, Whittington, Douglas A, Wu, Tian, Xi, Ning, Xu, Yang, Yakowec, Peter, Yang, Kevin, Zalameda, Leeanne P, Zhang, Nancy, Hughes, Paul, Norman, Mark H
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Journal Article
Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors
D’Angelo, Noel D, Bellon, Steven F, Booker, Shon K, Cheng, Yuan, Coxon, Angela, Dominguez, Celia, Fellows, Ingrid, Hoffman, Douglas, Hungate, Randall, Kaplan-Lefko, Paula, Lee, Matthew R, Li, Chun, Liu, Longbin, Rainbeau, Elizabeth, Reider, Paul J, Rex, Karen, Siegmund, Aaron, Sun, Yaxiong, Tasker, Andrew S, Xi, Ning, Xu, Shimin, Yang, Yajing, Zhang, Yihong, Burgess, Teresa L, Dussault, Isabelle, Kim, Tae-Seong
Published in Journal of medicinal chemistry (25.09.2008)
Published in Journal of medicinal chemistry (25.09.2008)
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Journal Article
Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases
Smith, Adrian L, D’Angelo, Noel D, Bo, Yunxin Y, Booker, Shon K, Cee, Victor J, Herberich, Brad, Hong, Fang-Tsao, Jackson, Claire L. M, Lanman, Brian A, Liu, Longbin, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Tadesse, Seifu, Tamayo, Nuria A, Wurz, Ryan P, Yang, Kevin, Andrews, Kristin L, Whittington, Douglas A, McCarter, John D, Miguel, Tisha San, Zalameda, Leeanne, Jiang, Jian, Subramanian, Raju, Mullady, Erin L, Caenepeel, Sean, Freeman, Daniel J, Wang, Ling, Zhang, Nancy, Wu, Tian, Hughes, Paul E, Norman, Mark H
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Journal Article
Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles
D’Angelo, Noel D., Peterson, Joseph J., Booker, Shon K., Fellows, Ingrid, Dominguez, Celia, Hungate, Randall, Reider, Paul J., Kim, Tae-Seong
Published in Tetrahedron letters (17.07.2006)
Published in Tetrahedron letters (17.07.2006)
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Journal Article
Discovery of 1 H -Pyrazol-3(2 H )-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)
Smith, Adrian L., Andrews, Kristin L., Beckmann, Holger, Bellon, Steven F., Beltran, Pedro J., Booker, Shon, Chen, Hao, Chung, Young-Ah, D’Angelo, Noel D., Dao, Jennifer, Dellamaggiore, Kenneth R., Jaeckel, Peter, Kendall, Richard, Labitzke, Katja, Long, Alexander M., Materna-Reichelt, Silvia, Mitchell, Petia, Norman, Mark H., Powers, David, Rose, Mark, Shaffer, Paul L., Wu, Michelle M., Lipford, J. Russell
Published in Journal of medicinal chemistry (12.02.2015)
Published in Journal of medicinal chemistry (12.02.2015)
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Journal Article
Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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inibidores de pl3 quinase e/ou motor
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Year of Publication 03.05.2016
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Year of Publication 03.05.2016
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Substituted Amid derivatives & methods of use
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Year of Publication 15.03.2014
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ΥΠΟΚΑΤΕΣΤΗΜΕΝΑ ΑΜΙΔΙΚΑ ΠΑΡΑΓΩΓΑ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΠΡΩΤΕΪΝΙΚΩΝ ΚΙΝΑΣΩΝ
YANG Kevin, GERMAIN Julie, HIRAI Satoko, CHOQUETTE Deborah, BELLON Steven, D´AMICO Derin, BOEZIO Alessandro, LIU Longbin, LA Daniel, SIEGMUND Aaron C, BOOKER Shon, HARMANGE Jean-Cristophe, ROVETO Philip, BAUER David, D´ANGELO Noel, DOMINGUEZ Celia, FELLOWS Ingrid M, LEE Matthew, GRACEFFA Russel, POTHASHMAN Michele, KIM Tae-Seong, NORMAL Mark H, XI Ning
Year of Publication 22.06.2016
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Year of Publication 22.06.2016
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Compuestos derivados de heterociclos sustituidos, inhibidores pi3k y/u objetivo mamifero de rapamicina (mtor); composicion farmaceutica que los comprende; y su uso en el tratamiento de melanoma, algun tipo de cancer tales como ovario, cuello uterino, mama, colon, recto, endometrio, entre otros
ANDREWS KRISTIN, HERBERICH BRADLEY, HONG FANG TSAO, JACKSON CLAIR, BO YUNXIN Y, BOOKER SHON, CEE VICTOR J, D"ANGELO NOEL
Year of Publication 16.03.2012
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Year of Publication 16.03.2012
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Inhibitors of PI3 kinase and / or MTOR
NISHIMURA NOBUKO, ANDREWS KRISTIN, BOOKER SHON, CEE VICTOR J, D. ANGELO NOEL, WU BIN, SMITH ADRIAN L, LIAO HONGYU, WURZ RYAN, TAMAYO NURIA A, BO YUNXIN Y, LIU LONGBIN, YANG KEVIN, LANMAN BRIAN A, HERBERICH BRADLEY J, PETTUS LIPING H, TADESSE SEIFU, HONG FANG-TSAO, JACKSON CLAIRE L. M, NORMAN MARK H, REED ANTHONY B
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Year of Publication 04.07.2012
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INHIBIDORES DE FOSFOINOSITIDA 3 CINASA Y/U OBJETIVO MAMÍFERO DE RAPAMICINA
NISHIMURA NOBUKO, ANDREWS KRISTIN, BOOKER SHON, CEE VICTOR J, WU BIN, JACKSON CLAIRE L.M, SMITH ADRIAN L, LIAO HONGYU, WURZ RYAN, TAMAYO NURIA A, BO YUNXIN Y, LIU LONGBIN, YANG KEVIN, LANMAN BRIAN A, HERBERICH BRADLEY J, TADESSE SEIFU, PETTUS LIPING H, HONG FANG-TSAO, NORMAN MARK H, D ANGELO NOEL, REED ANTHONY B
Year of Publication 15.05.2012
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Year of Publication 15.05.2012
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INHIBITORS OF PI3 KINASE AND / OR MTOR
MARK H. NORMAN, KEVIN YANG, NOEL D´ANGELO, BIN WU, BRIAN A. LANMAN, BRADLEY J. HERBERICH, RYAN WURZ, LIPING H. PETTUS, NOBUKO NISHIMURA, SEIFU TADESSE, HONGYU LIAO, CLAIRE L.M. JACKSON, FANG-TSAO HONG, ADRIAN L. SMITH, NURIA A. TAMAYO, ANTHONY B. REED, SHON BOOKER, VICTOR J. CEE, YUNXIN Y. BO, KRISTIN ANDREWS, LONGBIN LIU
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Year of Publication 18.11.2011
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INHIBIDORES DE FOSFOINOSITIDA 3 CINASA Y/U OBJETIVO MAMÍFERO
NOEL D´ANGELO, NISHIMURA NOBUKO, MARK H. NORMAN, ANDREWS KRISTIN, BOOKER SHON, BRIAN A. LANMAN, BRADLEY J. HERBERICH, WU BIN, LIPING H. PETTUS, CLAIRE L. M. JACKSON, LIAO HONGYU, WURZ RYAN, FANG-TSAO HONG, BO YUNXIN, LIU LONGBIN, ADRIAN L. SMITH, YANG KEVIN, ANTHONY B. REED, NURIA A. TAMAYO, TADESSE SEIFU, VICTOR J. CEE
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Year of Publication 30.11.2010
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DERIVADOS DE AMIDA SUSTITUIDA Y METODOS DE USO
CHOQUETTE, DEBORAH, BELLON, STEVEN, LEE, MATTHEW, ROVETO, PHILIP, GERMAIN, JULIE, BAUER, DAVID, FELLOWS, INGRID M, LA, DANIEL, D´ANGELO, NOEL, NORMAN, MARK H, HARMANGE, JEANRISTOPHE, XI, NING, GRACEFA, RUSSELL, YANG, KEVIN, KIM, TAE-SEONG, SIEGMUND, AARON, BOOKER, SHON, DOMINGUEZ, CELIA, HIRAI, SATOKO, LIU, LONGBIN, BOEZIO, ALESSANDRO, POTASHMAN, MICHELE, D´AMICO, DERIN
Year of Publication 30.11.2006
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Year of Publication 30.11.2006
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