Delineating the role of cooperativity in the design of potent PROTACs for BTK
Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2018)
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Journal Article
Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors
Flanagan, Mark E, Abramite, Joseph A, Anderson, Dennis P, Aulabaugh, Ann, Dahal, Upendra P, Gilbert, Adam M, Li, Chao, Montgomery, Justin, Oppenheimer, Stacey R, Ryder, Tim, Schuff, Brandon P, Uccello, Daniel P, Walker, Gregory S, Wu, Yan, Brown, Matthew F, Chen, Jinshan M, Hayward, Matthew M, Noe, Mark C, Obach, R. Scott, Philippe, Laurence, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Starr, Jeremy, Stroh, Justin, Che, Ye
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Journal Article
Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
Brown, Matthew F, Reilly, Usa, Abramite, Joseph A, Arcari, Joel T, Oliver, Robert, Barham, Rose A, Che, Ye, Chen, Jinshan Michael, Collantes, Elizabeth M, Chung, Seung Won, Desbonnet, Charlene, Doty, Jonathan, Doroski, Matthew, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, Marra, Andrea, McElroy, Eric, Melnick, Michael, Menard, Carol A, Montgomery, Justin I, Mullins, Lisa, Noe, Mark. C, O’Donnell, John, Penzien, Joseph, Plummer, Mark S, Price, Loren M, Shanmugasundaram, Veerabahu, Thoma, Christy, Uccello, Daniel P, Warmus, Joseph S, Wishka, Donn G
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
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Journal Article
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Journal Article
A Rational Approach to Catalytic Enantioselective Enolate Alkylation Using a Structurally Rigidified and Defined Chiral Quaternary Ammonium Salt under Phase Transfer Conditions
Corey, E. J, Xu, Feng, Noe, Mark C
Published in Journal of the American Chemical Society (17.12.1997)
Published in Journal of the American Chemical Society (17.12.1997)
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Journal Article
Inducing protein-protein interactions with molecular glues
Che, Ye, Gilbert, Adam M., Shanmugasundaram, Veerabahu, Noe, Mark C.
Published in Bioorganic & medicinal chemistry letters (15.08.2018)
Published in Bioorganic & medicinal chemistry letters (15.08.2018)
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Journal Article
An Asymmetric Synthesis of (2S,5S)-5-Substituted Azepane-2-Carboxylate Derivatives
Wishka, Donn G, Bédard, Marion, Brighty, Katherine E, Buzon, Richard A, Farley, Kathleen A, Fichtner, Michael W, Kauffman, Goss S, Kooistra, Jaap, Lewis, Jason G, O’Dowd, Hardwin, Samardjiev, Ivan J, Samas, Brian, Yalamanchi, Geeta, Noe, Mark C
Published in Journal of organic chemistry (18.03.2011)
Published in Journal of organic chemistry (18.03.2011)
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Journal Article
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Journal Article
Linezolid, the first oxazolidinone antibacterial agent
Leach, Karen L., Brickner, Steven J., Noe, Mark C., Miller, Paul F.
Published in Annals of the New York Academy of Sciences (01.03.2011)
Published in Annals of the New York Academy of Sciences (01.03.2011)
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Journal Article
Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry
DiRico, Kenneth J, Hua, Wenyi, Liu, Chang, Tucker, Joseph W, Ratnayake, Anokha S, Flanagan, Mark E, Troutman, Matthew D, Noe, Mark C, Zhang, Hui
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
The application of a mechanistic model leads to the extension of the Sharpless asymmetric dihydroxylation to allylic 4-methoxybenzoates and conformationally related amine and homoallylic alcohol derivatives
Corey, E. J, Guzman-Perez, Angel, Noe, Mark C
Published in Journal of the American Chemical Society (01.11.1995)
Published in Journal of the American Chemical Society (01.11.1995)
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Journal Article
Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections
Montgomery, Justin I, Brown, Matthew F, Reilly, Usa, Price, Loren M, Abramite, Joseph A, Arcari, Joel, Barham, Rose, Che, Ye, Chen, Jinshan Michael, Chung, Seung Won, Collantes, Elizabeth M, Desbonnet, Charlene, Doroski, Matthew, Doty, Jonathan, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, McAllister, Laura, McElroy, Eric, Menard, Carol A, Mitton-Fry, Mark, Mullins, Lisa, Noe, Mark C, O’Donnell, John, Oliver, Robert, Penzien, Joseph, Plummer, Mark, Shanmugasundaram, Veerabahu, Thoma, Christy, Tomaras, Andrew P, Uccello, Daniel P, Vaz, Alfin, Wishka, Donn G
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Journal Article
Pyridone-Conjugated Monobactam Antibiotics with Gram-Negative Activity
Brown, Matthew F, Mitton-Fry, Mark J, Arcari, Joel T, Barham, Rose, Casavant, Jeffrey, Gerstenberger, Brian S, Han, Seungil, Hardink, Joel R, Harris, Thomas M, Hoang, Thuy, Huband, Michael D, Lall, Manjinder S, Lemmon, M. Megan, Li, Chao, Lin, Jian, McCurdy, Sandra P, McElroy, Eric, McPherson, Craig, Marr, Eric S, Mueller, John P, Mullins, Lisa, Nikitenko, Antonia A, Noe, Mark C, Penzien, Joseph, Plummer, Mark S, Schuff, Brandon P, Shanmugasundaram, Veerabahu, Starr, Jeremy T, Sun, Jianmin, Tomaras, Andrew, Young, Jennifer A, Zaniewski, Richard P
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Journal Article
Discovery of Dap‑3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections
Magee, Thomas V, Brown, Matthew F, Starr, Jeremy T, Ackley, David C, Abramite, Joseph A, Aubrecht, Jiri, Butler, Andrew, Crandon, Jared L, Dib-Hajj, Fadia, Flanagan, Mark E, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Irvine, Rebecca, Kuhn, Michael, Leach, Karen L, Li, Bryan, Lin, Jian, Luke, David R, MacVane, Shawn H, Miller, Alita A, McCurdy, Sandra, McKim, James M, Nicolau, David P, Nguyen, Thuy-Trinh, Noe, Mark C, O’Donnell, John P, Seibel, Scott B, Shen, Yue, Stepan, Antonia F, Tomaras, Andrew P, Wilga, Paul C, Zhang, Li, Xu, Jinfeng, Chen, Jinshan Michael
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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Journal Article
The origin of greater than 200:1 enantioselectivity in a catalytic Diels-Alder reaction as revealed by physical and chemical studies
Corey, E. J, Loh, Teck Peng, Roper, Thomas D, Azimioara, Mihai D, Noe, Mark C
Published in Journal of the American Chemical Society (01.10.1992)
Published in Journal of the American Chemical Society (01.10.1992)
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Journal Article
X-ray Crystal and NMR Structure of a Highly Reactive Bidentate 1,2-Diamine−OsO4 Complex, Formally a 20-Electron Outer Valence Shell Species. Mechanistic Implications for the 1,2-Diamine-Accelerated Dihydroxylation of Olefins by OsO4
Corey, E. J, Sarshar, Sepehr, Azimioara, Mihai D, Newbold, Ronald C, Noe, Mark C
Published in Journal of the American Chemical Society (21.08.1996)
Published in Journal of the American Chemical Society (21.08.1996)
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