The structural basis for control of eukaryotic protein kinases
Endicott, Jane A, Noble, Martin E M, Johnson, Louise N
Published in Annual review of biochemistry (01.01.2012)
Published in Annual review of biochemistry (01.01.2012)
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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Douangamath, Alice, Fearon, Daren, Gehrtz, Paul, Krojer, Tobias, Lukacik, Petra, Owen, C. David, Resnick, Efrat, Strain-Damerell, Claire, Aimon, Anthony, Ábrányi-Balogh, Péter, Brandão-Neto, José, Carbery, Anna, Davison, Gemma, Dias, Alexandre, Downes, Thomas D., Dunnett, Louise, Fairhead, Michael, Firth, James D., Jones, S. Paul, Keeley, Aaron, Keserü, György M., Klein, Hanna F., Martin, Mathew P., Noble, Martin E. M., O’Brien, Peter, Powell, Ailsa, Reddi, Rambabu N., Skyner, Rachael, Snee, Matthew, Waring, Michael J., Wild, Conor, London, Nir, von Delft, Frank, Walsh, Martin A.
Published in Nature communications (07.10.2020)
Published in Nature communications (07.10.2020)
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FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation
Wood, Daniel J, Lopez-Fernandez, J. Daniel, Knight, Leanne E, Al-Khawaldeh, Islam, Gai, Conghao, Lin, Shengying, Martin, Mathew P, Miller, Duncan C, Cano, Céline, Endicott, Jane A, Hardcastle, Ian R, Noble, Martin E. M, Waring, Michael J
Published in Journal of medicinal chemistry (11.04.2019)
Published in Journal of medicinal chemistry (11.04.2019)
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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK
Brown, Nicholas R., Korolchuk, Svitlana, Martin, Mathew P., Stanley, Will A., Moukhametzianov, Rouslan, Noble, Martin E. M., Endicott, Jane A.
Published in Nature communications (13.04.2015)
Published in Nature communications (13.04.2015)
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Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors
Lochhead, Pamela A., Tucker, Julie A., Tatum, Natalie J., Wang, Jinhua, Oxley, David, Kidger, Andrew M., Johnson, Victoria P., Cassidy, Megan A., Gray, Nathanael S., Noble, Martin E. M., Cook, Simon J.
Published in Nature communications (13.03.2020)
Published in Nature communications (13.03.2020)
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Exiting the tunnel of uncertainty: crystal soak to validated hit
Martin, Mathew P., Noble, Martin E. M.
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2022)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2022)
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Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines
Coxon, Christopher R, Anscombe, Elizabeth, Harnor, Suzannah J, Martin, Mathew P, Carbain, Benoit, Golding, Bernard T, Hardcastle, Ian R, Harlow, Lisa K, Korolchuk, Svitlana, Matheson, Christopher J, Newell, David R, Noble, Martin E. M, Sivaprakasam, Mangaleswaran, Tudhope, Susan J, Turner, David M, Wang, Lan Z, Wedge, Stephen R, Wong, Christopher, Griffin, Roger J, Endicott, Jane A, Cano, Céline
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition
Wood, Daniel J, Korolchuk, Svitlana, Tatum, Natalie J, Wang, Lan-Zhen, Endicott, Jane A, Noble, Martin E M, Martin, Mathew P
Published in Cell chemical biology (17.01.2019)
Published in Cell chemical biology (17.01.2019)
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Journal Article
Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
Rowland, Rhianna J., Heath, Richard, Maskell, Daniel, Thompson, Rebecca F., Ranson, Neil A., Blaza, James N., Endicott, Jane A., Noble, Martin E. M., Salamina, Marco
Published in Scientific reports (03.07.2023)
Published in Scientific reports (03.07.2023)
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Generation of protein lattices by fusing proteins with matching rotational symmetry
Sinclair, John C., Davies, Karen M., Vénien-Bryan, Catherine, Noble, Martin E. M.
Published in Nature nanotechnology (31.07.2011)
Published in Nature nanotechnology (31.07.2011)
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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Tuning the Binding Affinity and Selectivity of Perfluoroaryl‐Stapled Peptides by Cysteine‐Editing
Verhoork, Sanne J. M., Jennings, Claire E., Rozatian, Neshat, Reeks, Judith, Meng, Jieman, Corlett, Emily K., Bunglawala, Fazila, Noble, Martin E. M., Leach, Andrew G., Coxon, Christopher R.
Published in Chemistry : a European journal (02.01.2019)
Published in Chemistry : a European journal (02.01.2019)
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Fragment expansion with NUDELs - poised DNA-encoded libraries
Salvini, Catherine L. A, Darlot, Benoit, Davison, Jack, Martin, Mathew P, Tudhope, Susan J, Turberville, Shannon, Kawamura, Akane, Noble, Martin E. M, Wedge, Stephen R, Crawford, James J, Waring, Michael J
Published in Chemical science (Cambridge) (09.08.2023)
Published in Chemical science (Cambridge) (09.08.2023)
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Cryo-EM structure of the CDK2-cyclin A-CDC25A complex
Rowland, Rhianna J., Korolchuk, Svitlana, Salamina, Marco, Tatum, Natalie J., Ault, James R., Hart, Sam, Turkenburg, Johan P., Blaza, James N., Noble, Martin E. M., Endicott, Jane A.
Published in Nature communications (09.08.2024)
Published in Nature communications (09.08.2024)
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Journal Article
Structure-based discovery of cyclin-dependent protein kinase inhibitors
Martin, Mathew P, Endicott, Jane A, Noble, Martin E M
Published in Essays in biochemistry (08.11.2017)
Published in Essays in biochemistry (08.11.2017)
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Recent developments in cyclin-dependent kinase biochemical and structural studies
Echalier, Aude, Endicott, Jane A., Noble, Martin E.M.
Published in Biochimica et biophysica acta (01.03.2010)
Published in Biochimica et biophysica acta (01.03.2010)
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Journal Article
Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design
Tan, Yaw Sing, Reeks, Judith, Brown, Christopher J, Thean, Dawn, Ferrer Gago, Fernando Jose, Yuen, Tsz Ying, Goh, Eunice Tze Leng, Lee, Xue Er Cheryl, Jennings, Claire E, Joseph, Thomas L, Lakshminarayanan, Rajamani, Lane, David P, Noble, Martin E. M, Verma, Chandra S
Published in The journal of physical chemistry letters (01.09.2016)
Published in The journal of physical chemistry letters (01.09.2016)
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Journal Article
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
Hardcastle, Ian R, Liu, Junfeng, Valeur, Eric, Watson, Anna, Ahmed, Shafiq U, Blackburn, Timothy J, Bennaceur, Karim, Clegg, William, Drummond, Catherine, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Gruber, Jan, Haggerty, Karen, Harrington, Ross W, Hutton, Claire, Kemp, Stuart, Lu, Xiaohong, McDonnell, James M, Newell, David R, Noble, Martin E. M, Payne, Sara L, Revill, Charlotte H, Riedinger, Christiane, Xu, Qing, Lunec, John
Published in Journal of medicinal chemistry (10.03.2011)
Published in Journal of medicinal chemistry (10.03.2011)
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Journal Article
Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release
Morese, Pasquale A., Anthony, Nahoum, Bodnarchuk, Michael, Jennings, Claire, Martin, Mathew P., Noble, Richard A., Phillips, Nicole, Thomas, Huw D., Wang, Lan Z., Lister, Andrew, Noble, Martin E. M., Ward, Richard A., Wedge, Stephen R., Stewart, Hannah L., Waring, Michael J.
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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