SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells
MALCOLM, B. A, LIU, R, INGRAVALLO, P, JIANG, C, KONG, R, LU, J, PICHARDO, J, PRONGAY, A, SKELTON, A, TONG, X, VENKATRAMAN, S, XIA, E, LAHSER, F, GIRIJAVALLABHAN, V, NJOROGE, F. G, AGRAWAL, S, BELANGER, B, BUTKIEWICZ, N, CHASE, R, GHEYAS, F, HART, A, HESK, D
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Published in Antimicrobial Agents and Chemotherapy (01.03.2006)
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Preclinical Characterization of the Antiviral Activity of SCH 900518 (Narlaprevir), a Novel Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease
TONG, X, ARASAPPAN, A, PRONGAY, A, RALSTON, R, SKELTON, A, XIA, E, ZHANG, R, NJOROGE, F. G, BENNETT, F, CHASE, R, FELD, B, GUO, Z, HART, A, MADISON, V, MALCOLM, B, PICHARDO, J
Published in Antimicrobial Agents and Chemotherapy (01.06.2010)
Published in Antimicrobial Agents and Chemotherapy (01.06.2010)
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Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034
Bogen, S., Arasappan, A., Pan, W., Ruan, S., Padilla, A., Saksena, A.K., Girijavallabhan, V., Njoroge, F.G.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Structural Interaction of Natural and Synthetic Inhibitors with the Venom Metalloproteinase, Atrolysin C (Form d)
Zhang, Dachuan, Botos, Istvan, Gomis-Rüth, Franz-Xaver, Doll, Ronald, Blood, Christine, Njoroge, F. George, Fox, Jay w., Bode, Wolfram, Meyer, Edgar F.
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.1994)
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Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds
Njoroge, F. George, Vibulbhan, Bancha, Rane, Dinananth F, Bishop, W. Robert, Petrin, Joanne, Patton, Robert, Bryant, Mathew S, Chen, K.-J, Nomeir, Amin A, Lin, C.-C, Liu, Ming, King, Ivan, Chen, Jianping, Lee, Suining, Yaremko, Bohdan, Dell, Janet, Lipari, Philip, Malkowski, Michael, Li, Zujun, Catino, Joseph, Doll, Ronald J, Girijavallabhan, V, Ganguly, Ashit K
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
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Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity
Njoroge, F. George, Vibulbhan, Bancha, Pinto, Patrick, Bishop, W. Robert, Bryant, Mathew S, Nomeir, Amin A, Lin, C.-C, Liu, Ming, Doll, Ronald J, Girijavallabhan, V, Ganguly, Ashit K
Published in Journal of medicinal chemistry (07.05.1998)
Published in Journal of medicinal chemistry (07.05.1998)
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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice
MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N
Published in Cancer research (Chicago, Ill.) (01.11.1998)
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Published in Cancer research (Chicago, Ill.) (01.11.1998)
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Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation
Mallams, A.K., Njoroge, F.G., Doll, R.J., Snow, M.E., Kaminski, J.J., Rossman, R.R., Vibulbhan, B., Bishop, W.R., Kirschmeier, P., Liu, M., Bryant, M.S., Alvarez, C., Carr, D., James, L., King, I., Li, Z., Lin, C.-C., Nardo, C., Petrin, J., Remiszewski, S.W., Taveras, A.G., Wang, S., Wong, J., Catino, J., Girijavallabhan, V., Ganguly, A.K.
Published in Bioorganic & medicinal chemistry (01.01.1997)
Published in Bioorganic & medicinal chemistry (01.01.1997)
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Impact of Naturally Occurring Variants of HCV Protease on the Binding of Different Classes of Protease Inhibitors
Tong, Xiao, Guo, Zhuyan, Wright-Minogue, Jacquelyn, Xia, Ellen, Prongay, Andrew, Madison, Vincent, Qiu, Ping, Venkatraman, Srikanth, Velazquez, Francisco, Njoroge, F. George, Malcolm, Bruce A.
Published in Biochemistry (Easton) (07.02.2006)
Published in Biochemistry (Easton) (07.02.2006)
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Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity
Njoroge, F.George, Vibulbhan, Bancha, Bishop, W.Robert, Kirschmeier, Paul, Bryant, Mathew S., Nomeir, Amin A., Liu, Ming, Doll, Ronald J., Girijavallabhan, Viyyoor M., Ganguly, Ashit K.
Published in Bioorganic & medicinal chemistry (01.05.1999)
Published in Bioorganic & medicinal chemistry (01.05.1999)
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Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease
Chen, Kevin X, Njoroge, F. George, Pichardo, John, Prongay, Andrew, Butkiewicz, Nancy, Yao, Nanhua, Madison, Vincent, Girijavallabhan, Viyyoor
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease
Zhang, Rumin, Beyer, Brian M., Durkin, James, Ingram, Richard, Njoroge, F.George, Windsor, William T., Malcolm, Bruce A.
Published in Analytical biochemistry (01.06.1999)
Published in Analytical biochemistry (01.06.1999)
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Hepatitis C virus NS3-4A serine protease inhibitors : Use of a P2-P1 cyclopropyl alanine combination for improved potency
BOGEN, S, SAKSENA, A. K, ARASAPPAN, A, GU, H, NJOROGE, F. G, GIRIJAVALLABHAN, V, PICHARDO, J, BUTKIEWICZ, N, PRONGAY, A, MADISON, V
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
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Enzymatic Kinetic Resolution of Piperidine Atropisomers: Synthesis of a Key Intermediate of the Farnesyl Protein Transferase Inhibitor, SCH66336
Morgan, Brian, Zaks, Aleksey, Dodds, David R, Liu, Jinchu, Jain, Rama, Megati, Sreeni, Njoroge, F. George, Girijavallabhan, Viyyoor M
Published in Journal of organic chemistry (08.09.2000)
Published in Journal of organic chemistry (08.09.2000)
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Hepatitis C virus NS3-4A serine protease inhibitors : SAR of P'2 moiety with improved potency
ARASAPPAN, A, NJOROGE, F. G, LOVEY, R. G, PAREKH, T, PIKE, R. E, PINTO, P, SANTHANAM, B, VENKATRAMAN, S, VACCARO, H, WANG, H, YANG, X, ZHU, Z, CHAN, T.-Y, MCKITTRICK, B, SAKSENA, A. K, GIRIJAVALLABHAN, V, PICHARDO, J, BUTKIEWICZ, N, INGRAM, R, MALCOLM, B, PRONGAY, A, YAO, N, MARTEN, B, BENNETT, F, MADISON, V, KEMP, S, LEVY, O, LIM-WILBY, M, TAMURA, S, GANGULY, A. K, BOGEN, S. L, CHEN, K, GU, H, HONG, L, JAO, E, LIU, Y.-T
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
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Published in Bioorganic & medicinal chemistry letters (01.10.2005)
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Characterization of resistance mutations against HCV ketoamide protease inhibitors
Tong, Xiao, Bogen, Stephane, Chase, Robert, Girijavallabhan, V., Guo, Zhuyan, Njoroge, F. George, Prongay, Andrew, Saksena, Anil, Skelton, Angela, Xia, Ellen, Ralston, Robert
Published in Antiviral research (01.03.2008)
Published in Antiviral research (01.03.2008)
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Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase
Njoroge, F. George, Doll, Ronald J., Vibulbhan, Bancha, Alvarez, Carmen S., Bishop, W. Robert, Petrin, Joanne, Kirschmeier, Paul, Carruthers, Nicholas I., Wong, Jesse K., Albanese, Margaret M., Piwinski, John J., Catino, Joseph, Girijavallabhan, V., Ganguly, Ashit K.
Published in Bioorganic & medicinal chemistry (01.01.1997)
Published in Bioorganic & medicinal chemistry (01.01.1997)
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