Particulate methane monooxygenase contains only mononuclear copper centers
Ross, Matthew O, MacMillan, Fraser, Wang, Jingzhou, Nisthal, Alex, Lawton, Thomas J, Olafson, Barry D, Mayo, Stephen L, Rosenzweig, Amy C, Hoffman, Brian M
Published in Science (American Association for the Advancement of Science) (10.05.2019)
Published in Science (American Association for the Advancement of Science) (10.05.2019)
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Journal Article
1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity
Nisthal, Alex, Lee, Sung-Hyung, Bonzon, Christine, Love, Ruschelle, Avery, Kendra N, Rashid, Rumana, Lertkiatmongkol, Panida, Rodriguez, Nicole, Leung, Irene, Karki, Sher, Barlow, Norman J, Chu, Seung Y, Moore, Gregory L, Desjarlais, John R
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
714 PD1 x TGFβR2 bispecifics selectively block TGFβR2 on PD1-positive T cells, promote T cell activation, and elicit an anti-tumor response in solid tumors
Moore, Gregory, Schubbert, Suzanne, Bonzon, Christine, Avery, Kendra, Rashid, Rumana, Pong, Erik, Ochyl, Lukasz, Nisthal, Alex, Chu, Seung, Ernst, James, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Abstract 1831: Affinity tuned XmAb®2+1 GPC3 x CD3 bispecific antibodies demonstrate selective activity in liver cancer models
Nisthal, Alex, Hassanzadeh-Kiabi, Nargess, Avery, Kendra N., Rashid, Rumana, Diaz, Juan E., Muchhal, Umesh S., Chu, Seung Y., Moore, Gregory L., Bykova, Katrina, Desjarlais, John R.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats
Moore, Gregory L., Bernett, Matthew J., Rashid, Rumana, Pong, Erik W., Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Nisthal, Alex, Diaz, Juan E., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.
Published in Methods (San Diego, Calif.) (01.02.2019)
Published in Methods (San Diego, Calif.) (01.02.2019)
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Abstract 5663: Affinity tuned XmAb®2+1 PSMA x CD3 bispecific antibodies demonstrate selective activity in prostate cancer models
Nisthal, Alex, Dragovich, Matthew, Pong, Erik W., Zeng, Veronica, Hedvat, Michael, Bonzon, Christine, Avery, Kendra, Rashid, Rumana, Ardila, Connie, Muchhal, Umesh S., Moore, Gregory L., Chu, Seung Y., Desjarlais, John R.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 2286: XmAb30819, an XmAb®2+1 ENPP3 x CD3 bispecific antibody for RCC, demonstrates safety and efficacy in in vivo preclinical studies
Nisthal, Alex, Lee, Sung-Hyung, Kim, Yoon Kyung, Bonzon, Christine, Rashid, Rumana, Avery, Kendra N., Bogaert, Liz, Ardila, Connie, Leung, Irene W., Rodriguez, Nicole, Muchhal, Umesh S., Moore, Gregory L., Chu, Seung Y., Desjarlais, John R.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
CD3 및 GPC3에 결합하는 이종이량체 항체
HASSANZADEH KIABI NARGESS, VARMA RAJAT, BERNETT MATTHEW J, NISTHAL ALEX, BYKOVA KATRINA
Year of Publication 07.11.2023
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Year of Publication 07.11.2023
Patent
Abstract 1860: Bispecific claudin-6 x CD3 antibodies in a 2 + 1 format demonstrate selectivity and activity on human ovarian cancer cells
Faber, Matthew S., Lee, Sung-Hyung, Kim, Yoon Kyung, Qi, Jing, Avery, Kendra N., Nguyen, Duc-Hanh T., Rashid, Rumana, Eivazi, Araz, Chu, Seung Y., Diaz, Juan E., Ardila, Connie, Love, Ruschelle, Nisthal, Alex, Barlow, Norman J., Bonzon, Christine, Muchhal, Umesh S., Bernett, Matthew J., Desjarlais, John R.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Cell-free protein synthesis enables high yielding synthesis of an active multicopper oxidase
Li, Jian, Lawton, Thomas J, Kostecki, Jan S, Nisthal, Alex, Fang, Jia, Mayo, Stephen L, Rosenzweig, Amy C, Jewett, Michael C
Published in Biotechnology journal (01.02.2016)
Published in Biotechnology journal (01.02.2016)
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Journal Article
BISPECIFIC CHECKPOINT INHIBITOR ANTIBODIES
HEDVAT MICHAEL, BONZON CHRISTINE, DESJARLAIS JOHN, MOORE GREGORY, MUCHHAL UMESH S, BERNETT MATTHEW, NISTHAL ALEX
Year of Publication 24.04.2023
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Year of Publication 24.04.2023
Patent
Abstract 2962: ASP2138, a novel 2+1 format, claudin 18.2 x CD3 bispecific antibody, demonstrates selectivity and activity in preclinical cancer models
Nakazawa, Taisuke, Tanaka, Hiroaki, Kikuchi, Aya, Rashid, Rumana, Avery, Kendra N., Qi, Jing, Nisthal, Alex, Shimazaki, Masashi, Shirasuna, Kenna
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 2784: Simultaneous checkpoint-checkpoint or checkpoint-costimulatory receptor targeting with bispecific antibodies promotes enhanced human T cell activation
Hedvat, Michael, Bonzon, Christine, Bernett, Matthew J., Moore, Gregory L., Avery, Kendra, Rashid, Rumana, Nisthal, Alex, Schubert, Suzanne, Varma, Rajat, Lee, Sung-Hyung, Bogaert, Liz, Leung, Irene W.L., Chu, Seung, Muchhal, Umesh, Desjarlais, John
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
1372 XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP
Nisthal, Alex, Sung-Hyung, Lee, Bonzon, Christine, Love, Ruschelle, Avery, Kendra, Rashid, Rumana, Lertkiatmongkol, Panida, Rodriguez, Nicole, Karki, Sher, Barlow, Norman, Chu, Seung, Moore, Gregory, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Abstract 1639: Combination of PD1 blockade and T cell costimulation by bispecific antibodies promotes human T cell activation and proliferation
Moore, Gregory L., Hedvat, Michael, Bernett, Matthew J., Varma, Rajat, Schubbert, Suzanne, Bonzon, Christine, Avery, Kendra N., Rashid, Rumana, Nisthal, Alex, Bogaert, Liz, Leung, Irene W., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
CD3과 CLDN6에 결합하는 이종이량체 항체
FABER MATTHEW S, DESJARLAIS JOHN R, BERNETT MATTHEW J, KIM YOON KYUNG, LEE SUNG HYUNG, NISTHAL ALEX, AVERY KENDRA N, CHU SEUNG Y, QI JING, BORCHERT CHAD
Year of Publication 13.11.2023
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Year of Publication 13.11.2023
Patent
Mechanism of an ATP-independent protein disaggregase: II. distinct molecular interactions drive multiple steps during aggregate disassembly
Jaru-Ampornpan, Peera, Liang, Fu-Cheng, Nisthal, Alex, Nguyen, Thang X, Wang, Pengcheng, Shen, Kuang, Mayo, Steven L, Shan, Shu-Ou
Published in The Journal of biological chemistry (10.05.2013)
Published in The Journal of biological chemistry (10.05.2013)
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