Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite
KAZUI, Miho, NISHIYA, Yumi, ISHIZUKA, Tomoko, HAGIHARA, Katsunobu, FARID, Nagy A, OKAZAKI, Osamu, IKEDA, Toshihiko, KURIHARA, Atsushi
Published in Drug metabolism and disposition (01.01.2010)
Published in Drug metabolism and disposition (01.01.2010)
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Journal Article
Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models
Yamada, Makiko, Inoue, Shin-Ichi, Sugiyama, Daisuke, Nishiya, Yumi, Ishizuka, Tomoko, Watanabe, Akiko, Watanabe, Kengo, Yamashita, Shinji, Watanabe, Nobuaki
Published in Drug metabolism and disposition (01.04.2020)
Published in Drug metabolism and disposition (01.04.2020)
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Journal Article
Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation
Kishino, Yuki, Hasegawa, Tomoko, Kato, Ayako, Nishiya, Yumi, Rozhnal, Veronika, Watanabe, Kyoko, Takasaki, Wataru, Yamoto, Takashi, Mori, Kazuhiko
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.02.2019)
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.02.2019)
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Journal Article
Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition
Nishiya, Yumi, Suzuki, Eiko, Ishizuka, Tomoko, Kazui, Miho, Sakurai, Hidetaka, Nakai, Daisuke
Published in Drug metabolism and pharmacokinetics (01.02.2020)
Published in Drug metabolism and pharmacokinetics (01.02.2020)
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Journal Article
Comparison of Human Cytochrome P450 Inhibition by the Thienopyridines Prasugrel, Clopidogrel, and Ticlopidine
Hagihara, Katsunobu, Nishiya, Yumi, Kurihara, Atsushi, Kazui, Miho, Farid, Nagy A., Ikeda, Toshihiko
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2008)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2008)
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Journal Article
Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin
Sawamura, Ryoko, Sakurai, Hidetaka, Wada, Naoya, Nishiya, Yumi, Honda, Tomoyo, Kazui, Miho, Kurihara, Atsushi, Shinagawa, Akira, Izumi, Takashi
Published in Biopharmaceutics & drug disposition (01.09.2015)
Published in Biopharmaceutics & drug disposition (01.09.2015)
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Journal Article
Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
NISHIYA, Yumi, HAGIHARA, Katsunobu, ITO, Takashi, TAJIMA, Masami, MIURA, Shin-Ichi, KURIHARA, Atsushi, FARID, Nagy A, IKEDA, Toshihiko
Published in Drug metabolism and disposition (01.03.2009)
Published in Drug metabolism and disposition (01.03.2009)
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Journal Article
Pharmacokinetics and metabolism of mirogabalin, a novel α 2 δ ligand, in rats and monkeys
Yamamura, Naotoshi, Uchiyama, Minoru, Takahashi, Makoto, Honda, Tomoyo, Nishiya, Yumi
Published in Xenobiotica (02.01.2022)
Published in Xenobiotica (02.01.2022)
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Journal Article
DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody-Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Yamato, Michiko, Hasegawa, Jun, Maejima, Takanori, Hattori, Chiharu, Kumagai, Kazuyoshi, Watanabe, Akiko, Nishiya, Yumi, Shibutani, Tomoko, Aida, Tetsuo, Hayakawa, Ichiro, Nakada, Takashi, Abe, Yuki, Agatsuma, Toshinori
Published in Molecular cancer therapeutics (01.04.2022)
Published in Molecular cancer therapeutics (01.04.2022)
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Journal Article
Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models
Suzuki, Hirokazu, Nagase, Shotaro, Saito, Chiemi, Takatsuka, Atsuko, Nagata, Motoko, Honda, Kokichi, Kaneda, Yuki, Nishiya, Yumi, Honda, Tomoyo, Ishizaka, Tomomichi, Nakamura, Kensuke, Nakada, Takashi, Abe, Yuki, Agatsuma, Toshinori
Published in Molecular cancer therapeutics (04.03.2024)
Published in Molecular cancer therapeutics (04.03.2024)
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Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity in preclinical models of RAS-mediated midostaurin-resistant acute myeloid leukemia cells
Aikawa, Tomoya, Togashi, Noriko, Iwanaga, Koichi, Okada, Hiroyuki, Nishiya, Yumi, Inoue, Shinichi, Levis, Mark J, Isoyama, Takeshi
Published in Oncotarget (17.03.2020)
Published in Oncotarget (17.03.2020)
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Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver
Asano, Daigo, Nakamura, Koichi, Nishiya, Yumi, Shiozawa, Hideyuki, Takakusa, Hideo, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Hamada, Takakazu, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Drug metabolism and disposition (01.01.2023)
Published in Drug metabolism and disposition (01.01.2023)
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Journal Article
Estimation of fraction of drug metabolism by a single UDP‐glucuronosyl transferase enzyme using relative expression factor
Honda, Tomoyo, Obuchi, Wataru, Nishiya, Yumi, Shibayama, Takahiro, Watanabe, Kengo, Watanabe, Nobuaki
Published in Biopharmaceutics & drug disposition (01.10.2022)
Published in Biopharmaceutics & drug disposition (01.10.2022)
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Journal Article
A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model
Machida, Yukino, Nakagawa, Makoto, Matsunaga, Hironori, Yamaguchi, Masayuki, Ogawara, Yoko, Shima, Yutaka, Yamagata, Kazutsune, Katsumoto, Takuo, Hattori, Ayuna, Itoh, Masato, Seki, Takahiko, Nishiya, Yumi, Nakamura, Koichi, Suzuki, Kanae, Imaoka, Tomoki, Baba, Daichi, Suzuki, Makoto, Sampetrean, Oltea, Saya, Hideyuki, Ichimura, Koichi, Kitabayashi, Issay
Published in Molecular cancer therapeutics (01.02.2020)
Published in Molecular cancer therapeutics (01.02.2020)
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Journal Article
Abstract 1318: Preclinical characterization of quizartinib and AC886, a metabolite of quizartinib, in AML models, and anti-leukemic activity of quizartinib on midostaurin-resistant AML cells
Aikawa, Tomoya, Togashi, Noriko, Iwanaga, Koichi, Okada, Hiroyuki, Nishiya, Yumi, Inoue, Shinichi, Levis, Mark J., Isoyama, Takeshi
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
Asano, Daigo, Hamaue, Syoya, Zahir, Hamim, Shiozawa, Hideyuki, Nishiya, Yumi, Kimura, Takako, Kazui, Miho, Yamamura, Naotoshi, Ikeguchi, Marie, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Watanabe, Toshiyuki, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Drug metabolism and disposition (01.03.2022)
Published in Drug metabolism and disposition (01.03.2022)
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Journal Article
CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
Asano, Daigo, Hamaue, Syoya, Zahir, Hamim, Shiozawa, Hideyuki, Nishiya, Yumi, Kimura, Takako, Kazui, Miho, Yamamura, Naotoshi, Ikeguchi, Marie, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Watanabe, Toshiyuki, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Drug metabolism and disposition (01.03.2022)
Published in Drug metabolism and disposition (01.03.2022)
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DRY POWDER PHARMACEUTICAL COMPOSITION FOR INHALATION
YOSHIE KENSUKE, KONG QING LIANG, YAMAKAWA SATORU, NISHIYA YUMI, INABA SHINICHI, INOUE KAZUHIRO
Year of Publication 26.09.2022
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Year of Publication 26.09.2022
Patent
Abstract 4891: Ifinatamab deruxtecan (I-DXd), a novel B7-H3-targeting antibody-drug conjugate, demonstrates efficient payload delivery into tumor through target-dependent internalization
Katsumata, Len, Deguchi, Tsuneo, Hasegawa, Jun, Yamato, Michiko, Nishiya, Yumi, Watanabe, Akiko, Honda, Tomoyo, Minami, Megumi, Kasanuki, Naomi, Maejima, Takanori, Muramatsu, Sumie, Herrmann, Monika, Schulte, Nina, Polier, Gernot, Wang, Xuya, Yoshida, Takanori, Izumi, Nanae, Qian, Xiaozhong, Agatsuma, Toshinori, Nakamaru, Kenji
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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