Semagacestat Is a Pseudo-Inhibitor of γ-Secretase
Tagami, Shinji, Yanagida, Kanta, Kodama, Takashi S., Takami, Mako, Mizuta, Naoki, Oyama, Hiroshi, Nishitomi, Kouhei, Chiu, Yu-wen, Okamoto, Toru, Ikeuchi, Takeshi, Sakaguchi, Gaku, Kudo, Takashi, Matsuura, Yoshiharu, Fukumori, Akio, Takeda, Masatoshi, Ihara, Yasuo, Okochi, Masayasu
Published in Cell reports (Cambridge) (03.10.2017)
Published in Cell reports (Cambridge) (03.10.2017)
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Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1
Tagami, Shinji, Okochi, Masayasu, Yanagida, Kanta, Ikuta, Akiko, Fukumori, Akio, Matsumoto, Naohiko, Ishizuka-Katsura, Yoshiko, Nakayama, Taisuke, Itoh, Naohiro, Jiang, Jingwei, Nishitomi, Kouhei, Kamino, Kouzin, Morihara, Takashi, Hashimoto, Ryota, Tanaka, Toshihisa, Kudo, Takashi, Chiba, Shigeru, Takeda, Masatoshi
Published in Molecular and Cellular Biology (01.01.2008)
Published in Molecular and Cellular Biology (01.01.2008)
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Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier
Morihara, Takashi, Hayashi, Noriyuki, Yokokoji, Mikiko, Akatsu, Hiroyasu, Silverman, Michael A., Kimura, Nobuyuki, Sato, Masahiro, Saito, Yuhki, Suzuki, Toshiharu, Yanagida, Kanta, Kodama, Takashi S., Tanaka, Toshihisa, Okochi, Masayasu, Tagami, Shinji, Kazui, Hiroaki, Kudo, Takashi, Hashimoto, Ryota, Itoh, Naohiro, Nishitomi, Kouhei, Yamaguchi-Kabata, Yumi, Tsunoda, Tatsuhiko, Takamura, Hironori, Katayama, Taiichi, Kimura, Ryo, Kamino, Kouzin, Hashizume, Yoshio, Takeda, Masatoshi
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2014)
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Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration
Takata, Kazuyuki, Hirata-Fukae, Chiho, Becker, Amanda G., Chishiro, Saori, Gray, Audrey J., Nishitomi, Kouhei, Franz, Andreas H., Sakaguchi, Gaku, Kato, Akira, Mattson, Mark P., LaFerla, Frank M., Aisen, Paul S., Kitamura, Yoshihisa, Matsuoka, Yasuji
Published in The European journal of neuroscience (01.11.2007)
Published in The European journal of neuroscience (01.11.2007)
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Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor
Itoh, Naohiro, Okochi, Masayasu, Tagami, Shinji, Nishitomi, Kouhei, Nakayama, Taisuke, Yanagida, Kanta, Fukumori, Akio, Jiang, Jingwei, Mori, Kohji, Hosono, Motoko, Kikuchi, Jyunko, Nakano, Yuko, Takinami, Yoshihiko, Dohi, Keiji, Nishigaki, Atsuko, Takemoto, Hiroshi, Minagawa, Kazuyuki, Katoh, Takaaki, Willem, Michael, Haass, Christian, Morihara, Takashi, Tanaka, Toshihisa, Kudo, Takashi, Hasegawa, Hiroshi, Nishimura, Masaki, Sakaguchi, Gaku, Kato, Akira, Takeda, Masatoshi
Published in Neuro-degenerative diseases (01.01.2009)
Published in Neuro-degenerative diseases (01.01.2009)
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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice2
Nishitomi, Kouhei, Sakaguchi, Gaku, Horikoshi, Yuko, Gray, Audrey J., Maeda, Masahiro, Hirata‐Fukae, Chiho, Becker, Amanda G., Hosono, Motoko, Sakaguchi, Isako, Minami, S. Sakura, Nakajima, Yoshihiro, Li, Hui‐Fang, Takeyama, Chie, Kihara, Tsuyoshi, Ota, Akinobu, Wong, Philip C., Aisen, Paul S., Kato, Akira, Kinoshita, Noriaki, Matsuoka, Yasuji
Published in Journal of neurochemistry (01.12.2006)
Published in Journal of neurochemistry (01.12.2006)
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Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α2A-adrenergic receptors in rats
Nishitomi, Kouhei, Yano, Koji, Kobayashi, Mika, Jino, Kohei, Kano, Takuya, Horiguchi, Naotaka, Shinohara, Shunji, Hasegawa, Minoru
Published in Behavioural brain research (01.06.2018)
Published in Behavioural brain research (01.06.2018)
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Journal Article
Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α 2A -adrenergic receptors in rats
Nishitomi, Kouhei, Yano, Koji, Kobayashi, Mika, Jino, Kohei, Kano, Takuya, Horiguchi, Naotaka, Shinohara, Shunji, Hasegawa, Minoru
Published in Behavioural brain research (01.06.2018)
Published in Behavioural brain research (01.06.2018)
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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β-amyloid production and tau phosphorylation in Alzheimer disease
Kimura, Ryo, Kamino, Kouzin, Yamamoto, Mitsuko, Nuripa, Aidaralieva, Kida, Tomoyuki, Kazui, Hiroaki, Hashimoto, Ryota, Tanaka, Toshihisa, Kudo, Takashi, Yamagata, Hidehisa, Tabara, Yasuharu, Miki, Tetsuro, Akatsu, Hiroyasu, Kosaka, Kenji, Funakoshi, Eishi, Nishitomi, Kouhei, Sakaguchi, Gaku, Kato, Akira, Hattori, Hideyuki, Uema, Takeshi, Takeda, Masatoshi
Published in Human molecular genetics (01.01.2007)
Published in Human molecular genetics (01.01.2007)
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PRECLINICAL MULTI-SPECIES PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF THE ORAL BACE INHIBITOR JNJ-54861911
Ito, Hisanori, Yamakawa, Hidekuni, Nishitomi, Kouhei, Hosono, Motoko, Unemura, Chie, Azuma, Yuki, Ando, Azusa, Izumi, Takaya, Nakajima, Yoshihiro, Tsuji, Hiroki, Kihara, Tsuyoshi, Jacobs, Tom, Borghys, Herman, Koriyama, Yuji, Kato, Akira, Sakaguchi, Gaku
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice
NISHITOMI, Kouhei, SAKAGUCHI, Gaku, NAKAJIMA, Yoshihiro, LI, Hui-Fang, TAKEYAMA, Chie, KIHARA, Tsuyoshi, OTA, Akinobu, WONG, Philip C, AISEN, Paul S, KATO, Akira, KINOSHITA, Noriaki, MATSUOKA, Yasuji, HORIKOSHI, Yuko, GRAY, Audrey J, MAEDA, Masahiro, HIRATA-FUKAE, Chiho, BECKER, Amanda G, HOSONO, Motoko, SAKAGUCHI, Isako, SAKURA MINAMI, S
Published in Journal of neurochemistry (01.12.2006)
Published in Journal of neurochemistry (01.12.2006)
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Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-[Beta] accumulation modifier
Morihara, Takashi, Hayashi, Noriyuki, Yokokoji, Mikiko, Akatsu, Hiroyasu, Silverman, Michael A, Kimura, Nobuyuki, Sato, Masahiro, Saito, Yuhki, Suzuki, Toshiharu, Yanagida, Kanta, Kodama, Takashi S, Tanaka, Toshihisa, Okochi, Masayasu, Tagami, Shinji, Kazui, Hiroaki, Kudo, Takashi, Hashimoto, Ryota, Itoh, Naohiro, Nishitomi, Kouhei, Yamaguchi-Kabata, Yumi, Tsunoda, Tatsuhiko, Takamura, Hironori, Katayama, Taiichi, Kimura, Ryo, Kamino, Kouzin, Hashizume, Yoshio, Takeda, Masatoshi
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2014)
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Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2014)
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ANTI-sAPPbeta ANTIBODY
YAMAKAWA, HIDEKUNI, YAMAUCHI, AKIRA, FUKUDA, ISAO, MORITA, ATSUSHI, ONODA, JUNJI, YAMANE, SHOJI, NISHITOMI, KOUHEI, TAKAHASHI, TATSUYA, YOSHIDA, YASUNOBU
Year of Publication 08.08.2013
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Year of Publication 08.08.2013
Patent
Levels of the surrogate marker for Aβ42 (i.e., APL1β) in CSF of sporadicAlzheimer disease patients increase before the onset of its clinical symptoms
Yanagida, Kanta, Okochi, Masayasu, Tagami, Shinji, Nakayama, Taisuke, Kodama, Takashi S., Nishitomi, Kouhei, Jiang, Jingwei, Mori, Kohji, Tatsumi, Shin-ichi, Kazui, Hiroaki, Tanaka, Toshihisa, Morihara, Takashi, Hashimoto, Ryota, Kudo, Takashi, Takeda, Masatoshi
Published in Neuroscience research (2010)
Published in Neuroscience research (2010)
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Journal Article
P1‐171: Analysis of an Aβ‐like peptide in CSF to reveal whether and how the cleavage precision of presenilin/γ‐secretase is altered in AD patients
Tagami, Shinji, Okochi, Masayasu, Yanagida, Kanta, Nakayama, Taisuke, Kodama, Takashi, Nishitomi, Kouhei, Tatsumi, Shin‐Ichi, Arai, Tetsuaki, Ikeuchi, Takeshi, Kasuga, Kensaku, Ikeda, Masaki, Deguchi, Kentaro, Kazui, Hiroaki, Morihara, Takashi, Tanaka, Toshihisa, Kudo, Takashi, Tsuchiya, Kuniaki, Akiyama, Haruhiko, Kuwano, Ryozou, Takeda, Masatoshi
Published in Alzheimer's & dementia (01.07.2009)
Published in Alzheimer's & dementia (01.07.2009)
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Journal Article
Analysis of an Aβ-like peptide in CSF to reveal whether and how the cleavage precision of presenilin/γ-secretase is altered in AD patients
Tagami, Shinji, Okochi, Masayasu, Yanagida, Kanta, Nakayama, Taisuke, Kodama, Takashi, Nishitomi, Kouhei, Tatsumi, Shin-Ichi, Arai, Tetsuaki, Ikeuchi, Takeshi, Kasuga, Kensaku, Ikeda, Masaki, Deguchi, Kentaro, Kazui, Hiroaki, Morihara, Takashi, Tanaka, Toshihisa, Kudo, Takashi, Tsuchiya, Kuniaki, Akiyama, Haruhiko, Kuwano, Ryozou, Takeda, Masatoshi
Published in Alzheimer's & dementia (01.07.2009)
Published in Alzheimer's & dementia (01.07.2009)
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Journal Article
Novel APLP1 Peptide In CSF Is Useful For Diagnosis Of Sporadic Alzheimer's Disease
Okochi, Masayasu, Tagami, Shinji, Yanagida, Kanta, Nishitomi, Kouhei, Arai, Tetsuaki, Ikeuchi, Takeshi, Kasuga, Kensaku, Tokuda, Takahiro, Kondo, Masaki, Ikeda, Masaki, Deguchi, Kentaro, Steiner, Harald, Haass, Christian, Kuwano, Ryozo, Takeda, Masatoshi
Published in Alzheimer's & dementia (01.07.2009)
Published in Alzheimer's & dementia (01.07.2009)
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Journal Article
P4‐296: Novel APLP1 Peptide In CSF Is Useful For Diagnosis Of Sporadic Alzheimer's Disease
Okochi, Masayasu, Tagami, Shinji, Yanagida, Kanta, Nishitomi, Kouhei, Arai, Tetsuaki, Ikeuchi, Takeshi, Kasuga, Kensaku, Tokuda, Takahiro, Kondo, Masaki, Ikeda, Masaki, Deguchi, Kentaro, Steiner, Harald, Haass, Christian, Kuwano, Ryozo, Takeda, Masatoshi
Published in Alzheimer's & dementia (01.07.2009)
Published in Alzheimer's & dementia (01.07.2009)
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Journal Article
P3-339: Characteristics of membrane-bound factors affecting presenilin/γ-secretase cleavages
Mori, Kohji K, Okochi, Masayasu, Tagami, Shinji, Yanagida, Kanta, Nakayama, Taisuke, Nishitomi, Kouhei, Jiang, Jingwei, Tatsumi, Shinichi, Kodama, Takashi, Fukumori, Akio, Takeda, Masatoshi
Published in Alzheimer's & dementia (01.07.2008)
Published in Alzheimer's & dementia (01.07.2008)
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