Dual Allosteric Inhibition of SHP2 Phosphatase
Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Hengyu, Argintaru, Andreea, Chen, Zhouliang, Glick, Meir, Hao, Huai-Xiang, Kato, Mitsunori, Koenig, Robert, LaRochelle, Jonathan R, Liu, Gang, McNeill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele A, Perez, Lawrence B, Paris, Gregory, Quinn, Christopher M, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael David, Williams, Sarah L, Stams, Travis, Blacklow, Stephen C, Acker, Michael G, LaMarche, Matthew J
Published in ACS chemical biology (16.03.2018)
Published in ACS chemical biology (16.03.2018)
Get full text
Journal Article
Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic
Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
Get full text
Journal Article
Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases
Han, Wooseok, Ding, Yu, Chen, Zheng, Langowski, John L, Bellamacina, Cornelia, Rico, Alice, Nishiguchi, Gisele A, Lan, Jiong, Atallah, Gordana, Lindvall, Mika, Lin, Song, Zang, Richard, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Garcia, Pablo, Burger, Matthew T
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
Get full text
Journal Article
Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
Get full text
Journal Article
Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases
Nishiguchi, Gisele A., Atallah, Gordana, Bellamacina, Cornelia, Burger, Matthew T., Ding, Yu, Feucht, Paul H., Garcia, Pablo D., Han, Wooseok, Klivansky, Liana, Lindvall, Mika
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Get full text
Journal Article
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold
Nishiguchi, Gisele A., Burger, Matthew T., Han, Wooseok, Lan, Jiong, Atallah, Gordana, Tamez, Victoriano, Lindvall, Mika, Bellamacina, Cornelia, Garcia, Pablo, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Wong, Kent
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Get full text
Journal Article
7,11-epi-Thyrsiferol: Completion of Its Synthesis, Evaluation of Its Antimitotic Properties, and the Further Development of an SAR Model
Nishiguchi, Gisele A, Graham, John, Bouraoui, A, Jacobs, R. S, Little, R. Daniel
Published in Journal of organic chemistry (04.08.2006)
Published in Journal of organic chemistry (04.08.2006)
Get full text
Journal Article
세레브론 단백질의 조절제로서의 치환된 N-아릴설폰아미드 유사체
MIN JAEKI, NISHIGUCHI GISELE A, PRICE JEANINE, RANKOVIC ZORAN, CHANG YUNCHAO, FISHER MARCUS, SOURAV DAS, KERAMATNIA FATEMEH, MCGOWAN KEVIN, MULLIGHAN CHARLES G
Year of Publication 14.06.2022
Get full text
Year of Publication 14.06.2022
Patent
COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED N-(2-CHLORO-6-METHYLPHENYL)-2-((6-(6-MEMBERED HETEROCYCLOALKYL)-2-METHYLPYRIMIDIN-4-YL)AMINO)THIAZOLE-5-CARBOXAMIDE ANALOGUES
YANG, Jun J, RANKOVIC, Zoran, HU, Jianzhong, JARUSIEWICZ, Jamie, NISHIGUCHI, Gisele A
Year of Publication 01.06.2023
Get full text
Year of Publication 01.06.2023
Patent
SUBSTITUTED N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-5-YL)ARYLSULFONAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN
KERAMATNIA, Fatemeh, FISHER, Marcus, MCGOWAN, Kevin, MULLIGHAN, Charles G, CHANG, Yunchao, RANKOVIC, Zoran, PRICE, Jeanine, NISHIGUCHI, Gisele A, Das, Sourav, MIN, Jaeki
Year of Publication 25.04.2024
Get full text
Year of Publication 25.04.2024
Patent
SUBSTITUTED N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-5-YL)ARYLSULFONAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN
KERAMATNIA, Fatemeh, FISHER, Marcus, MCGOWAN, Kevin, MULLIGHAN, Charles G, CHANG, Yunchao, RANKOVIC, Zoran, PRICE, Jeanine, NISHIGUCHI, Gisele A, MIN, Jaeki, SOURAV, Das
Year of Publication 10.04.2024
Get full text
Year of Publication 10.04.2024
Patent
SUBSTITUTED N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-5-YL)ARYLSULFONAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN
KERAMATNIA, Fatemeh, FISHER, Marcus, MCGOWAN, Kevin, MULLIGHAN, Charles G, CHANG, Yunchao, RANKOVIC, Zoran, PRICE, Jeanine, NISHIGUCHI, Gisele A, MIN, Jaeki, SOURAV, Das
Year of Publication 02.08.2023
Get full text
Year of Publication 02.08.2023
Patent
SUBSTITUTED N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-5-YL)ARYLSULFONAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN
KERAMATNIA, Fatemeh, FISHER, Marcus, MCGOWAN, Kevin, MULLIGHAN, Charles G, CHANG, Yunchao, RANKOVIC, Zoran, PRICE, Jeanine, NISHIGUCHI, Gisele A, MIN, Jaeki, SOURAV, Das
Year of Publication 01.06.2023
Get full text
Year of Publication 01.06.2023
Patent
SUBSTITUTED N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-5-YL)ARYLSULFONAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN
KERAMATNIA, Fatemeh, FISHER, Marcus, MCGOWAN, Kevin, MULLIGHAN, Charles G, CHANG, Yunchao, RANKOVIC, Zoran, PRICE, Jeanine, NISHIGUCHI, Gisele A, MIN, Jaeki, SOURAV, Das
Year of Publication 01.09.2022
Get full text
Year of Publication 01.09.2022
Patent