Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Hirai, Hiroshi, Iwasawa, Yoshikazu, Okada, Megumu, Arai, Tsuyoshi, Nishibata, Toshihide, Kobayashi, Makiko, Kimura, Toshifumi, Kaneko, Naoki, Ohtani, Junko, Yamanaka, Kazunori, Itadani, Hiraku, Takahashi-Suzuki, Ikuko, Fukasawa, Kazuhiro, Oki, Hiroko, Nambu, Tadahiro, Jiang, Jian, Sakai, Takumi, Arakawa, Hiroharu, Sakamoto, Toshihiro, Sagara, Takeshi, Yoshizumi, Takashi, Mizuarai, Shinji, Kotani, Hidehito
Published in Molecular cancer therapeutics (01.11.2009)
Published in Molecular cancer therapeutics (01.11.2009)
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Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor
Mizuarai, Shinji, Yamanaka, Kazunori, Itadani, Hiraku, Arai, Tsuyoshi, Nishibata, Toshihide, Hirai, Hiroshi, Kotani, Hidehito
Published in Molecular cancer (08.06.2009)
Published in Molecular cancer (08.06.2009)
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Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants
Shibata, Hiroko, Kamada, Haruhiko, Kobayashi-Nishibata, Kyoko, Yoshioka, Yasuo, Nishibata, Toshihide, Abe, Yasuhiro, Nomura, Tetsuya, Nabeshi, Hiromi, Minowa, Kyoko, Mukai, Yohei, Nakagawa, Shinsaku, Mayumi, Tadanori, Tsunoda, Shin-ichi, Tsutsumi, Yasuo
Published in Biochimica et biophysica acta (01.08.2007)
Published in Biochimica et biophysica acta (01.08.2007)
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MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil
Hirai, Hiroshi, Arai, Tsuyoshi, Okada, Megumu, Nishibata, Toshihide, Kobayashi, Makiko, Sakai, Naoko, Imagaki, Kazuhide, Ohtani, Junko, Sakai, Takumi, Yoshizumi, Takashi, Mizuarai, Shinji, Iwasawa, Yoshikazu, Kotani, Hidehito
Published in Cancer biology & therapy (01.04.2010)
Published in Cancer biology & therapy (01.04.2010)
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Effect of anti-claudin 18.2 monoclonal antibody zolbetuximab alone or combined with chemotherapy or programmed cell death-1 blockade in syngeneic and xenograft gastric cancer models
Nishibata, Toshihide, Weng, Jane, Omori, Keisuke, Sato, Yuji, Nakazawa, Taisuke, Suzuki, Tomoyuki, Yamada, Tomohiro, Nakajo, Ikumi, Kinugasa, Fumitaka, Türeci, Özlem, Şahin, Uğur, Yoshida, Taku
Published in Journal of pharmacological sciences (01.07.2024)
Published in Journal of pharmacological sciences (01.07.2024)
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Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy
Nishibata, Toshihide, Amino, Nobuaki, Tanaka-Kado, Ruriko, Tsujimoto, Susumu, Kawashima, Tomoko, Konagai, Satoshi, Suzuki, Tomoyuki, Takeuchi, Masahiro
Published in BioMed research international (2023)
Published in BioMed research international (2023)
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Site-specific PEGylation of a lysine-deficient TNF-[alpha] with full bioactivity
Yamamoto, Yoko, Tsutsumi, Yasuo, Yoshioka, Yasuo, Nishibata, Toshihide, Kobayashi, Kyoko, Okamoto, Takayuki, Mukai, Yohei, Shimizu, Tomoe, Nakagawa, Shinsaku, Nagata, Satoshi, Tadanori Mayumi
Published in Nature biotechnology (01.05.2003)
Published in Nature biotechnology (01.05.2003)
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Site-specific PEGylation of a lysine-deficient TNF-α with full bioactivity
Tsutsumi, Yasuo, Yamamoto, Yoko, Yoshioka, Yasuo, Nishibata, Toshihide, Kobayashi, Kyoko, Okamoto, Takayuki, Mukai, Yohei, Shimizu, Tomoe, Nakagawa, Shinsaku, Nagata, Satoshi, Mayumi, Tadanori
Published in Nature biotechnology (01.05.2003)
Published in Nature biotechnology (01.05.2003)
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Optimal site-specific PEGylation of mutant TNF-α improves its antitumor potency
Yoshioka, Yasuo, Tsutsumi, Yasuo, Ikemizu, Shinji, Yamamoto, Yoko, Shibata, Hiroko, Nishibata, Toshihide, Mukai, Yohei, Okamoto, Takayuki, Taniai, Madoka, Kawamura, Maki, Abe, Yasuhiro, Nakagawa, Shinsaku, Nagata, Satoshi, Yamagata, Yuriko, Mayumi, Tadanori
Published in Biochemical and biophysical research communications (19.03.2004)
Published in Biochemical and biophysical research communications (19.03.2004)
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DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE
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Year of Publication 08.11.2007
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Year of Publication 08.11.2007
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Year of Publication 28.11.2017
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Year of Publication 28.11.2017
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Year of Publication 31.10.2017
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Year of Publication 31.10.2017
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Year of Publication 31.05.2017
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Year of Publication 31.05.2017
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SAKAMOTO, TOSHIHIRO, YOSHIZUMI, TAKASHI, FURUYAMA, HIDETOMO, NIIYAMA, KENJI, SUNAMI, SATOSHI, YAMAMOTO, FUYUKI, BAMBA, MAKOTO, SAGARA, TAKESHI, TAKAHASHI, KEIJI, OTSUKI, SACHIE, NISHIBATA, TOSHIHIDE, HIRAI, HIROSHI, GOTO, YASUHIRO
Year of Publication 14.03.2017
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Year of Publication 14.03.2017
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Year of Publication 24.02.2017
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Year of Publication 24.02.2017
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Year of Publication 13.02.2017
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Year of Publication 13.02.2017
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Year of Publication 25.01.2017
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Year of Publication 25.01.2017
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Year of Publication 03.01.2017
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Year of Publication 03.01.2017
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Year of Publication 02.11.2016
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Year of Publication 02.11.2016
Patent
USE OF BIOMARKER(S) TO IDENTIFY A WEE1 INHIBITOR RESPONSIVE PATIENT AND METHODS OF TREATING CANCER MEDIATED BY DYSFUNCTIONAL OR ABERRANT P53 VIA ADMINISTRATION OF A WEE1 INHIBITOR
ITADANI, HIRAKU, NISHIBATA, TOSHIHIDE, ARAI, TSUYOSHI, HIRAI, HIROSHI, MIZUARAI, SHINJI, YAMANAKA, KAZUNORI, KOTANI, HIDEHITO
Year of Publication 06.03.2013
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Year of Publication 06.03.2013
Patent