Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
Hommel, Ulrich, Erbel, Paul, Schiering, Nikolaus, D'Arcy, Allan, Renatus, Martin, Kroemer, Markus, Lim, Siew Pheng, Yin, Zheng, Keller, Thomas H, Vasudevan, Subhash G
Published in Nature structural & molecular biology (01.04.2006)
Published in Nature structural & molecular biology (01.04.2006)
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Journal Article
Direct Renin Inhibitors as a New Therapy for Hypertension
Webb, Randy L, Schiering, Nikolaus, Sedrani, Richard, Maibaum, Jürgen
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Journal Article
Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments
Vulpetti, Anna, Schiering, Nikolaus, Dalvit, Claudio
Published in Proteins, structure, function, and bioinformatics (01.12.2010)
Published in Proteins, structure, function, and bioinformatics (01.12.2010)
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Journal Article
macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target
Schiering, Nikolaus, D’Arcy, Allan, Villard, Frederic, Simić, Oliver, Kamke, Marion, Monnet, Gaby, Hassiepen, Ulrich, Svergun, Dmitri I, Pulfer, Ruth, Eder, Jörg, Raman, Prakash, Bodendorf, Ursula
Published in Proceedings of the National Academy of Sciences - PNAS (27.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (27.12.2011)
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Journal Article
Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor c-Met and Its Complex with the Microbial Alkaloid K-252a
Schiering, Nikolaus, Knapp, Stefan, Marconi, Marina, Flocco, Maria M., Cui, Jean, Perego, Rita, Rusconi, Luisa, Cristiani, Cinzia
Published in Proceedings of the National Academy of Sciences - PNAS (28.10.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (28.10.2003)
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Journal Article
Regulation of the Wild-Type and Y1235D Mutant Met Kinase Activation
Cristiani, Cinzia, Rusconi, Luisa, Perego, Rita, Schiering, Nikolaus, Kalisz, Henryk M, Knapp, Stefan, Isacchi, Antonella
Published in Biochemistry (Easton) (01.11.2005)
Published in Biochemistry (Easton) (01.11.2005)
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Journal Article
Iron, DtxR, and the regulation of diphtheria toxin expression
Tao, X, Schiering, N, Zeng, H Y, Ringe, D, Murphy, J R
Published in Molecular microbiology (01.10.1994)
Published in Molecular microbiology (01.10.1994)
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Journal Article
Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19 F NMR Binding Assay with Predicted 19 F NMR Chemical Shifts
Vulpetti, Anna, Lingel, Andreas, Dalvit, Claudio, Schiering, Nikolaus, Oberer, Lukas, Henry, Chrystelle, Lu, Yipin
Published in ChemMedChem (05.07.2022)
Published in ChemMedChem (05.07.2022)
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Journal Article
Efficient Screening of Target‐Specific Selected Compounds in Mixtures by 19F NMR Binding Assay with Predicted 19F NMR Chemical Shifts
Vulpetti, Anna, Lingel, Andreas, Dalvit, Claudio, Schiering, Nikolaus, Oberer, Lukas, Henry, Christelle, Lu, Yipin
Published in ChemMedChem (05.07.2022)
Published in ChemMedChem (05.07.2022)
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Journal Article
MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans
Koch, Alexander W., Schiering, Nikolaus, Melkko, Samu, Ewert, Stefan, Salter, Janeen, Zhang, Yiming, McCormack, Peter, Yu, Jianying, Huang, Xueming, Chiu, Yu-Hsin, Chen, Zhiping, Schleeger, Simone, Horny, Geraldine, DiPetrillo, Keith, Muller, Lionel, Hein, Andreas, Villard, Frederic, Scharenberg, Meike, Ramage, Paul, Hassiepen, Ulrich, Côté, Serge, DeGagne, Julie, Krantz, Carsten, Eder, Jörg, Stoll, Brian, Kulmatycki, Kenneth, Feldman, David L., Hoffmann, Peter, Basson, Craig T., Frost, Robert J.A., Khder, Yasser
Published in Blood (28.03.2019)
Published in Blood (28.03.2019)
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Journal Article
Structure of neprilysin in complex with the active metabolite of sacubitril
Schiering, Nikolaus, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Logel, Claude, Cumin, Frederic, Ksander, Gary M., Wiesmann, Christian, Karki, Rajeshri G., Mogi, Muneto
Published in Scientific reports (15.06.2016)
Published in Scientific reports (15.06.2016)
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Journal Article
FACTOR XI ANTIBODY AND METHOD OF USE
JORG EDER, ULRICH HASSIEPEN, NIKOLAUS SCHIERING, SAMU MELKKO, STEFAN EWERT, YASSER KHDER, LORENZ M MAYR
Year of Publication 28.02.2024
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Year of Publication 28.02.2024
Patent
Trypsin inhibitors for the treatment of pancreatitis
Brandl, Trixi, Simic, Oliver, Skaanderup, Philip R., Namoto, Kenji, Berst, Frederic, Ehrhardt, Claus, Schiering, Nikolaus, Mueller, Irene, Woelcke, Julian
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
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Journal Article
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach
Lorthiois, Edwige, Roache, James, Barnes-Seeman, David, Altmann, Eva, Hassiepen, Ulrich, Turner, Gordon, Duvadie, Rohit, Hornak, Viktor, Karki, Rajeshri G, Schiering, Nikolaus, Weihofen, Wilhelm A, Perruccio, Francesca, Calhoun, Amy, Fazal, Tanzina, Dedic, Darija, Durand, Corinne, Dussauge, Solene, Fettis, Kamal, Tritsch, Fabien, Dentel, Celine, Druet, Adelaide, Liu, Donglei, Kirman, Louise, Lachal, Julie, Namoto, Kenji, Bevan, Douglas, Mo, Rose, Monnet, Gabriela, Muller, Lionel, Zessis, Richard, Huang, Xueming, Lindsley, Loren, Currie, Treeve, Chiu, Yu-Hsin, Fridrich, Cary, Delgado, Peter, Wang, Shuangxi, Hollis-Symynkywicz, Micah, Berghausen, Joerg, Williams, Eric, Liu, Hong, Liang, Guiqing, Kim, Hyungchul, Hoffmann, Peter, Hein, Andreas, Ramage, Paul, D’Arcy, Allan, Harlfinger, Stefanie, Renatus, Martin, Ruedisser, Simon, Feldman, David, Elliott, Jason, Sedrani, Richard, Maibaum, Juergen, Adams, Christopher M
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Journal Article
FACTOR XI ANTIBODIES AND METHODS OF USE
JORG EDER, ULRICH HASSIEPEN, NIKOLAUS SCHIERING, SAMU MELKKO, STEFAN EWERT, YASSER KHDER, LORENZ M MAYR
Year of Publication 30.07.2020
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Year of Publication 30.07.2020
Patent
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors
Kawanami, Toshio, Karki, Rajeshri G, Cody, Emma, Liu, Qian, Liang, Guiqing, Ksander, Gary M, Rigel, Dean F, Schiering, Nikolaus, Gong, Yongjin, Coppola, Gary M, Iwaki, Yuki, Sun, Robert, Neubert, Alan, Fan, Li, Ingles, Sara, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Jeng, Arco Y, Leung-Chu, Jennifer, Liu, Jing, Beil, Michael, Fu, Fumin, Chen, Wei, Cumin, Frederic, Wiesmann, Christian, Mogi, Muneto
Published in ACS medicinal chemistry letters (13.02.2020)
Published in ACS medicinal chemistry letters (13.02.2020)
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Journal Article
Fluorescence Lifetime-Based Competitive Binding Assays for Measuring the Binding Potency of Protease Inhibitors In Vitro
Boettcher, Andreas, Gradoux, Nathalie, Lorthiois, Edwige, Brandl, Trixi, Orain, David, Schiering, Nikolaus, Cumin, Frederic, Woelcke, Julian, Hassiepen, Ulrich
Published in Journal of biomolecular screening (01.07.2014)
Published in Journal of biomolecular screening (01.07.2014)
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Journal Article
Fragment-Based Screening by Biochemical Assays: Systematic Feasibility Studies with Trypsin and MMP12
Boettcher, Andreas, Ruedisser, Simon, Erbel, Paulus, Vinzenz, Daniela, Schiering, Nikolaus, Hassiepen, Ulrich, Rigollier, Pascal, Mayr, Lorenz M., Woelcke, Julian
Published in Journal of biomolecular screening (01.10.2010)
Published in Journal of biomolecular screening (01.10.2010)
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Journal Article
Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors
Ehara, Takeru, Irie, Osamu, Kosaka, Takatoshi, Kanazawa, Takanori, Breitenstein, Werner, Grosche, Philipp, Ostermann, Nils, Suzuki, Masaki, Kawakami, Shimpei, Konishi, Kazuhide, Hitomi, Yuko, Toyao, Atsushi, Gunji, Hiroki, Cumin, Frederic, Schiering, Nikolaus, Wagner, Trixie, Rigel, Dean F, Webb, Randy L, Maibaum, Jürgen, Yokokawa, Fumiaki
Published in ACS medicinal chemistry letters (10.07.2014)
Published in ACS medicinal chemistry letters (10.07.2014)
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