Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity
Imaizumi, Tomoyoshi, Akaiwa, Michinori, Abe, Tomoaki, Nigawara, Takahiro, Koike, Takanori, Satake, Yoshiki, Watanabe, Kazushi, Kaneko, Osamu, Amano, Yasushi, Mori, Kenichi, Yamanaka, Yosuke, Nagashima, Takeyuki, Shimazaki, Masashi, Kuramoto, Kazuyuki
Published in Bioorganic & medicinal chemistry (01.10.2022)
Published in Bioorganic & medicinal chemistry (01.10.2022)
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Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl} prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors
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Published in Bioorganic & medicinal chemistry (15.01.2024)
Published in Bioorganic & medicinal chemistry (15.01.2024)
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Year of Publication 08.08.2024
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Year of Publication 30.09.2021
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Year of Publication 08.10.2019
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Year of Publication 09.08.2018
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Year of Publication 22.12.2014
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Year of Publication 24.10.2013
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Year of Publication 17.01.2012
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Year of Publication 28.10.2010
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Year of Publication 21.10.2010
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Year of Publication 19.04.2007
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Year of Publication 23.07.2009
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Year of Publication 08.03.2007
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Year of Publication 22.05.2024
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Year of Publication 06.04.2023
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Year of Publication 27.04.2006
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Year of Publication 20.04.2006
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Year of Publication 08.02.2023
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