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Published in Journal of medicinal chemistry (12.11.2020)
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HIV capsid is a tractable target for small molecule therapeutic intervention
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Published in Scientific reports (27.08.2019)
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Peptidomimetic α‑Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV‑2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability
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Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Published in European journal of medicinal chemistry (15.10.2021)
Published in European journal of medicinal chemistry (15.10.2021)
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Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors
Bai, Bing, Arutyunova, Elena, Khan, Muhammad Bashir, Lu, Jimmy, Joyce, Michael A, Saffran, Holly A, Shields, Justin A, Kandadai, Appan Srinivas, Belovodskiy, Alexandr, Hena, Mostofa, Vuong, Wayne, Lamer, Tess, Young, Howard S, Vederas, John C, Tyrrell, D. Lorne, Lemieux, M. Joanne, Nieman, James A
Published in MedChemComm (20.10.2021)
Published in MedChemComm (20.10.2021)
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Published in Bioorganic & medicinal chemistry (01.05.2023)
Published in Bioorganic & medicinal chemistry (01.05.2023)
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Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria
HERNANDEZ, Vincent, CREPIN, Thibaut, MEEWAN, Maliwan, MOHAN, Manisha, WEIMIN MAO, ROCK, Fernando L, SEXTON, Holly, SHEORAN, Anita, YANCHEN ZHANG, ZHANG, Yong-Kang, ZHOU, Yasheen, NIEMAN, James A, PALENCIA, Andrés, MAHIPAL REDDY ANUGULA, EL MEHDI KERAMANE, SAVARIRAJ, Kingsley, SHEKHAR REDDY, D, SHARMA, Rashmi, SUBEDI, Rajendra, SINGH, Rajeshwar, O'LEARY, Ann, SIMON, Nerissa L, DE MARSH, Peter L, CUSACK, Stephen, MUSHTAQ, Shazad, WARNER, Marina, LIVERMORE, David M, ALLEY, M. R. K, PLATTNER, Jacob J, AKAMA, Tsutomu, BAKER, Stephen J, WEI BU, LISA FENG, FREUND, Yvonne R, LIANG LIU
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
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Deuteration for Metabolic Stabilization of SARS-CoV‑2 Inhibitors GC373 and Nirmatrelvir
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Published in Organic letters (11.08.2023)
Published in Organic letters (11.08.2023)
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Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase
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Published in Journal of chemical information and modeling (28.12.2020)
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Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center
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Published in FEBS letters (21.09.2012)
Published in FEBS letters (21.09.2012)
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Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
Vuong, Wayne, Fischer, Conrad, Khan, Muhammad Bashir, van Belkum, Marco J., Lamer, Tess, Willoughby, Kurtis D., Lu, Jimmy, Arutyunova, Elena, Joyce, Michael A., Saffran, Holly A., Shields, Justin A., Young, Howard S., Nieman, James A., Tyrrell, D. Lorne, Lemieux, M. Joanne, Vederas, John C.
Published in European journal of medicinal chemistry (15.10.2021)
Published in European journal of medicinal chemistry (15.10.2021)
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SARS-CoV‑2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals
Chen, Sizhu Amelia, Arutyunova, Elena, Lu, Jimmy, Khan, Muhammad Bashir, Rut, Wioletta, Zmudzinski, Mikolaj, Shahbaz, Shima, Iyyathurai, Jegan, Moussa, Eman W., Turner, Zoe, Bai, Bing, Lamer, Tess, Nieman, James A., Vederas, John C., Julien, Olivier, Drag, Marcin, Elahi, Shokrollah, Young, Howard S., Lemieux, M. Joanne
Published in ACS central science (26.04.2023)
Published in ACS central science (26.04.2023)
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The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism
Arutyunova, Elena, Belovodskiy, Alexandr, Chen, Pu, Khan, Muhammad Bashir, Joyce, Michael, Saffran, Holly, Lu, Jimmy, Turner, Zoe, Bai, Bing, Lamer, Tess, Young, Howard S., Vederas, John C., Tyrrell, D. Lorne, Lemieux, M. Joanne, Nieman, James A.
Published in ACS bio & med chem au (20.12.2023)
Published in ACS bio & med chem au (20.12.2023)
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SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals
Chen, Sizhu Amelia, Arutyunova, Elena, Lu, Jimmy, Khan, Muhammad Bashir, Rut, Wioletta, Zmudzinski, Mikolaj, Shahbaz, Shima, Iyyathurai, Jegan, Moussa, Eman W, Turner, Zoe, Bai, Bing, Lamer, Tess, Nieman, James A, Vederas, John C, Julien, Olivier, Drag, Marcin, Elahi, Shokrollah, Young, Howard S, Lemieux, M Joanne
Published in ACS central science (26.04.2023)
Published in ACS central science (26.04.2023)
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Bioactivation of Flutamide Metabolites by Human Liver Microsomes
PING KANG, DALVIE, Deepak, SMITH, Evan, ZHOU, Sue, DEESE, Alan, NIEMAN, James A
Published in Drug metabolism and disposition (01.07.2008)
Published in Drug metabolism and disposition (01.07.2008)
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Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent
Akama, Tsutomu, Virtucio, Charlotte, Dong, Chen, Kimura, Richard, Zhang, Yong-Kang, Nieman, James A., Sharma, Rashmi, Lu, Xiaosong, Sales, Marcelo, Singh, Rajeshwar, Wu, Anne, Fan, Xiao-Qing, Liu, Liang, Plattner, Jacob J., Jarnagin, Kurt, Freund, Yvonne R.
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo
LOGANZO, Frank, DISCAFANI, Carolyn M, SINGANALLORE, Thiruvikraman, KHAFIZOVA, Gulnaz, PORUCHYNSKY, Marianne S, FOJO, Tito, NIEMAN, James A, AYRAL-KALOUSTIAN, Semiramis, ZASK, Arie, ANDERSEN, Raymond J, GREENBERGER, Lee M, ANNABLE, Tami, BEYER, Carl, MUSTO, Sylvia, HARI, Malathi, XINGZHI TAN, HARDY, Carolyn, HERNANDEZ, Richard, BAXTER, Michelle
Published in Cancer research (Chicago, Ill.) (15.04.2003)
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Published in Cancer research (Chicago, Ill.) (15.04.2003)
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Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility
Nieman, James A., Nair, Sajiv K., Heasley, Steven E., Schultz, Brenda L., Zerth, Herbert M., Nugent, Richard A., Chen, Ke, Stephanski, Kevin J., Hopkins, Todd A., Knechtel, Mary L., Oien, Nancee L., Wieber, Janet L., Wathen, Michael W.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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