Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma
Girotti, Maria R, Pedersen, Malin, Sanchez-Laorden, Berta, Viros, Amaya, Turajlic, Samra, Niculescu-Duvaz, Dan, Zambon, Alfonso, Sinclair, John, Hayes, Andrew, Gore, Martin, Lorigan, Paul, Springer, Caroline, Larkin, James, Jorgensen, Claus, Marais, Richard
Published in Cancer discovery (01.02.2013)
Published in Cancer discovery (01.02.2013)
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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Tang, HaoRan, Leung, Leo, Saturno, Grazia, Viros, Amaya, Smith, Duncan, Di Leva, Gianpiero, Morrison, Eamonn, Niculescu-Duvaz, Dan, Lopes, Filipa, Johnson, Louise, Dhomen, Nathalie, Springer, Caroline, Marais, Richard
Published in Nature communications (18.04.2017)
Published in Nature communications (18.04.2017)
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Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships
Leung, Leo, Niculescu-Duvaz, Dan, Smithen, Deborah, Lopes, Filipa, Callens, Cedric, McLeary, Robert, Saturno, Grazia, Davies, Lawrence, Aljarah, Mohammed, Brown, Michael, Johnson, Louise, Zambon, Alfonso, Chambers, Tim, Ménard, Delphine, Bayliss, Natasha, Knight, Ruth, Fish, Laura, Lawrence, Rae, Challinor, Mairi, Tang, HaoRan, Marais, Richard, Springer, Caroline
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
Wan, Paul T.C, Garnett, Mathew J, Roe, S.Mark, Lee, Sharlene, Niculescu-Duvaz, Dan, Good, Valerie M, Project, Cancer Genome, Jones, C.Michael, Marshall, Christopher J, Springer, Caroline J, Barford, David, Marais, Richard
Published in Cell (19.03.2004)
Published in Cell (19.03.2004)
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Gatekeeper mutations mediate resistance to BRAF-targeted therapies
Whittaker, Steven, Kirk, Ruth, Hayward, Robert, Zambon, Alfonso, Viros, Amaya, Cantarino, Neus, Affolter, Annette, Nourry, Arnaud, Niculescu-Duvaz, Dan, Springer, Caroline, Marais, Richard
Published in Science translational medicine (09.06.2010)
Published in Science translational medicine (09.06.2010)
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B-RAF is a therapeutic target in melanoma
KARASARIDES, Maria, CHILOECHES, Antonio, SPRINGER, Caroline J, MARAIS, Richard, HAYWARD, Robert, NICULESCU-DUVAZ, Dan, SCANLON, Ian, FRIEDLOS, Frank, OGILVIE, Lesley, HEDLEY, Douglas, MARTIN, Jan, MARSHALL, Christopher J
Published in Oncogene (19.08.2004)
Published in Oncogene (19.08.2004)
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Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Tang, HaoRan, Leung, Leo, Saturno, Grazia, Viros, Amaya, Smith, Duncan, Leva, Gianpiero Di, Morrison, Eamonn, Niculescu-Duvaz, Dan, Lopes, Filipa, Johnson, Louise, Dhomen, Nathalie, Springer, Caroline, Marais, Richard
Published in Nature communications (18.07.2019)
Published in Nature communications (18.07.2019)
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Structure-Activity Relationship in Cationic Lipid Mediated Gene Transfection
Niculescu-Duvaz, Dan, Heyes, James, Springer, Caroline
Published in Current medicinal chemistry (01.07.2003)
Published in Current medicinal chemistry (01.07.2003)
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C-end your drugs using peptide tags
Niculescu-Duvaz, Dan, Springer, Caroline, Marais, Richard
Published in Pigment cell and melanoma research (01.04.2010)
Published in Pigment cell and melanoma research (01.04.2010)
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BRAF as a therapeutic target: a patent review (2006 - 2012)
Zambon, Alfonso, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Marais, Richard, Springer, Caroline J
Published in Expert opinion on therapeutic patents (01.02.2013)
Published in Expert opinion on therapeutic patents (01.02.2013)
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1-(5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL)-3-[2-FLUORO-4-[(3-OXO-4H-PYRIDO[2,3-B]PYRAZIN-8-YL)OXY]PHENYL]UREA DERIVATIVES AS RAF INHIBITORS FOR THE TREATMENT OF CANCER
NICULESCU DUVAZ ION, GIROTTI ROMINA, NICULESCU DUVAZ DAN, ZAMBON ALFONSO, MARAIS RICHARD, SPRINGER CAROLINE JOY
Year of Publication 06.07.2016
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Year of Publication 06.07.2016
Patent
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
Su, Fei, Viros, Amaya, Milagre, Carla, Trunzer, Kerstin, Bollag, Gideon, Spleiss, Olivia, Reis-Filho, Jorge S, Kong, Xiangju, Koya, Richard C, Flaherty, Keith T, Chapman, Paul B, Kim, Min Jung, Hayward, Robert, Martin, Matthew, Yang, Hong, Wang, Qiongqing, Hilton, Holly, Hang, Julie S, Noe, Johannes, Lambros, Maryou, Geyer, Felipe, Dhomen, Nathalie, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Zambon, Alfonso, Preece, Natasha, Robert, Lídia, Otte, Nicholas J, Mok, Stephen, Kee, Damien, Ma, Yan, Zhang, Chao, Habets, Gaston, Burton, Elizabeth A, Wong, Bernice, Nguyen, Hoa, Kockx, Mark, Andries, Luc, Lestini, Brian, Nolop, Keith B, Lee, Richard J, Joe, Andrew K, Troy, James L, Gonzalez, Rene, Hutson, Thomas E, Puzanov, Igor, Chmielowski, Bartosz, Springer, Caroline J, McArthur, Grant A, Sosman, Jeffrey A, Lo, Roger S, Ribas, Antoni, Marais, Richard
Published in The New England journal of medicine (19.01.2012)
Published in The New England journal of medicine (19.01.2012)
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Journal Article
BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling
Sanchez-Laorden, Berta, Viros, Amaya, Girotti, Maria Romina, Pedersen, Malin, Saturno, Grazia, Zambon, Alfonso, Niculescu-Duvaz, Dan, Turajlic, Samra, Hayes, Andrew, Gore, Martin, Larkin, James, Lorigan, Paul, Cook, Martin, Springer, Caroline, Marais, Richard
Published in Science signaling (25.03.2014)
Published in Science signaling (25.03.2014)
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Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma
Girotti, Maria Romina, Lopes, Filipa, Preece, Natasha, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Whittaker, Steven, Saturno, Grazia, Viros, Amaya, Pedersen, Malin, Suijkerbuijk, Bart M.J.M., Menard, Delphine, McLeary, Robert, Johnson, Louise, Fish, Laura, Ejiama, Sarah, Sanchez-Laorden, Berta, Hohloch, Juliane, Carragher, Neil, Macleod, Kenneth, Ashton, Garry, Marusiak, Anna A., Fusi, Alberto, Brognard, John, Frame, Margaret, Lorigan, Paul, Marais, Richard, Springer, Caroline
Published in Cancer cell (12.01.2015)
Published in Cancer cell (12.01.2015)
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2‑Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth
Smithen, Deborah A, Leung, Leo M. H, Challinor, Mairi, Lawrence, Rae, Tang, HaoRan, Niculescu-Duvaz, Dan, Pearce, Simon P, Mcleary, Robert, Lopes, Filipa, Aljarah, Mohammed, Brown, Michael, Johnson, Louise, Thomson, Graeme, Marais, Richard, Springer, Caroline
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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Small molecule inhibitors of BRAF in clinical trials
Zambon, Alfonso, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow
Brown, Michael, Aljarah, Mohammed, Asiki, Hannah, Leung, Leo M. H, Smithen, Deborah A, Miller, Natalie, Nemeth, Gabor, Davies, Lawrence, Niculescu-Duvaz, Dan, Zambon, Alfonso, Springer, Caroline
Published in Organic process research & development (15.01.2021)
Published in Organic process research & development (15.01.2021)
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3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE
PORTER RODERICK, BAYFORD MELANIE JAYNE, ELLIOTT RICHARD JAMES ROWLAND, NICULESCU DUVAZ DAN, PERRIOR TREVOR ROBERT, KEY REBEKAH ELISABETH, LORD CHRISTOPHER JAMES, ASHWORTH ALAN, JARVIS ASHLEY NICHOLAS, FIRTH CLARK STUART, BOFFEY RAYMOND JOHN
Year of Publication 06.01.2015
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Year of Publication 06.01.2015
Patent
Abstract LB-212: Therapeutic efficacy of the paradox-breaking panRAF and SRC drug CCT3833/BAL3833 in KRAS-driven cancer models
Saturno, Grazia, Lopes, Filipa, Girotti, Maria Romina, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Johnson, Louise, Preece, Natasha, Viros, Amaya, Pedersen, Malin, McLeary, Robert, Knight, Ruth, Lee, Rebecca, Holovanchuk, Denys, Lorigan, Paul, Dhomen, Nathalie, Marais, Richard, Springer, Caroline
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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