Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors
Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien, Gessier, Francois
Published in Journal of medicinal chemistry (27.08.2015)
Published in Journal of medicinal chemistry (27.08.2015)
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Journal Article
2‑Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4
Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus-Porta, Diana, Wartmann, Markus, Galuba, Inga, Fairhurst, Robin A
Published in ACS medicinal chemistry letters (08.03.2018)
Published in ACS medicinal chemistry letters (08.03.2018)
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Journal Article
A New Approach to (−)-Swainsonine by Ruthenium-Catalyzed Ring Rearrangement
Buschmann, Nicole, Rückert, Anke, Blechert, Siegfried
Published in Journal of organic chemistry (14.06.2002)
Published in Journal of organic chemistry (14.06.2002)
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Journal Article
Studies on Oxidopyrylium [5 + 2] Cycloadditions: Toward a General Synthetic Route to the C12-Hydroxy Daphnetoxins
Wender, Paul A, Bi, F. Christopher, Buschmann, Nicole, Gosselin, Francis, Kan, Cindy, Kee, Jung-Min, Ohmura, Hirofumi
Published in Organic letters (09.11.2006)
Published in Organic letters (09.11.2006)
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Journal Article
Abstract 1684: PDX-derived 3D InSightTM immune-competent tumor microtissues as ex-vivo human model for evaluating therapeutic responses
Wardwell, Judi, Chiovaro, Francesca, Buschmann, Nicole, Strebel, Silvan, Wolf, Armin, Agarkova, Irina
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4
Fairhurst, Robin A, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin, Mario, Wirth, Jasmin, Graus-Porta, Diana, Weiss, Andreas, Kiffe, Michael, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Sterker, Dario, Stamm, Christelle, Adler, Flavia, Buhles, Alexandra, Schadt, Heiko, Couttet, Philippe, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Voshol, Johannes, Ostermann, Nils, Zou, Chao, Berghausen, Jörg, Del Rio Espinola, Alberto, Jahnke, Wolfgang, Furet, Pascal
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Journal Article
FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Weiss, Andreas, Adler, Flavia, Buhles, Alexandra, Stamm, Christelle, Fairhurst, Robin A, Kiffe, Michael, Sterker, Dario, Centeleghe, Mario, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Schadt, Heiko S, Couttet, Philippe, Wolf, Armin, Wang, Youzhen, Barzaghi-Rinaudo, Patrizia, Murakami, Masato, Kauffmann, Audrey, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Furet, Pascal, Blank, Jutta, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Abstract 52: PDX-derived 3D InSightTM tumor microtissues as ex-vivo human experimental models for evaluating therapeutic responses
Chiovaro, Francesca, Agarkova, Irina, Buschmann, Nicole, Pichon, Chloe', Langova, Teresa, Maier, Armin, Schueler, Julia, Guye, Patrick
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing
Pissot Soldermann, Carole, Simic, Oliver, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Wartmann, Markus, Bigaud, Marc, Weiss, Andreas, McSheehy, Paul, Endres, Ralf, Santos, Paulo, Blank, Jutta, Schuffenhauer, Ansgar, Bold, Guido, Buschmann, Nicole, Zoller, Thomas, Altmann, Eva, Manley, Paul W, Dix, Ina, Buchdunger, Elisabeth, Scesa, Julien, Quancard, Jean, Schlapbach, Achim, Bornancin, Frédéric, Radimerski, Thomas, Régnier, Catherine H
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
Namoto, Kenji, Baader, Clara, Orsini, Vanessa, Landshammer, Alexandro, Breuer, Eva, Dinh, Kieu Trinh, Ungricht, Rosemarie, Pikiolek, Monika, Laurent, Stephane, Lu, Bo, Aebi, Alexandra, Schönberger, Katharina, Vangrevelinghe, Eric, Evrova, Olivera, Sun, Tianliang, Annunziato, Stefano, Lachal, Julie, Redmond, Emily, Wang, Louis, Wetzel, Kristie, Capodieci, Paola, Turner, Jonathan, Schutzius, Gabi, Unterreiner, Vincent, Trunzer, Markus, Buschmann, Nicole, Behnke, Dirk, Machauer, Rainer, Scheufler, Clemens, Parker, Christian N., Ferro, Magali, Grevot, Armelle, Beyerbach, Armin, Lu, Wei-Yu, Forbes, Stuart J., Wagner, Jürgen, Bouwmeester, Tewis, Liu, Jun, Sohal, Bindi, Sahambi, Sukhdeep, Greenbaum, Linda E., Lohmann, Felix, Hoppe, Philipp, Cong, Feng, Sailer, Andreas W., Ruffner, Heinz, Glatthar, Ralf, Humar, Bostjan, Clavien, Pierre-Alain, Dill, Michael T., George, Elizabeth, Maibaum, Jürgen, Liberali, Prisca, Tchorz, Jan S.
Published in Cell stem cell (04.04.2024)
Published in Cell stem cell (04.04.2024)
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Journal Article
Bioorthogonal Probes for the Study of MDM2-p53 Inhibitors in Cells and Development of High-Content Screening Assays for Drug Discovery
D'Alessandro, Pier Luca, Buschmann, Nicole, Kaufmann, Markus, Furet, Pascal, Baysang, Frederic, Brunner, Reto, Marzinzik, Andreas, Vorherr, Thomas, Stachyra, Therese-Marie, Ottl, Johannes, Lizos, Dimitrios E., Cobos-Correa, Amanda
Published in Angewandte Chemie International Edition (23.12.2016)
Published in Angewandte Chemie International Edition (23.12.2016)
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Journal Article
Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities
Wender, Paul A., Buschmann, Nicole, Cardin, Nathan B., Jones, Lisa R., Kan, Cindy, Kee, Jung-Min, Kowalski, John A., Longcore, Kate E.
Published in Nature chemistry (01.08.2011)
Published in Nature chemistry (01.08.2011)
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Journal Article
Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region
Fairhurst, Robin A., Knoepfel, Thomas, Leblanc, Catherine, Buschmann, Nicole, Gaul, Christoph, Blank, Jutta, Galuba, Inga, Trappe, Joerg, Zou, Chao, Voshol, Johannes, Genick, Christine, Brunet-Lefeuvre, Peggy, Bitsch, Francis, Graus-Porta, Diana, Furet, Pascal
Published in MedChemComm (01.08.2017)
Published in MedChemComm (01.08.2017)
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Journal Article
Correction to “2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4”
Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus-Porta, Diana, Wartmann, Markus, Galuba, Inga, Fairhurst, Robin A
Published in ACS medicinal chemistry letters (12.11.2020)
Published in ACS medicinal chemistry letters (12.11.2020)
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Journal Article
A Framework for Optimizing High-Content Imaging of 3D Models for Drug Discovery
Wardwell-Swanson, Judith, Suzuki, Mahomi, Dowell, Karen G., Bieri, Manuela, Thoma, Eva C., Agarkova, Irina, Chiovaro, Francesca, Strebel, Silvan, Buschmann, Nicole, Greve, Frauke, Frey, Olivier
Published in SLAS discovery (01.08.2020)
Published in SLAS discovery (01.08.2020)
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