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C–H Arylation in the Formation of a Complex Pyrrolopyridine, the Commercial Synthesis of the Potent JAK2 Inhibitor, BMS-911543

C–H Arylation in the Formation of a Complex Pyrrolopyridine, the Commercial Synthesis of the Potent JAK2 Inhibitor, BMS-911543

by Fox, Richard J, Cuniere, Nicolas L, Bakrania, Lopa, Wei, Carolyn, Strotman, Neil A, Hay, Michael, Fanfair, Dayne, Regens, Christopher, Beutner, Gregory L, Lawler, Michael, Lobben, Paul, Soumeillant, Maxime C, Cohen, Benjamin, Zhu, Keming, Skliar, Dimitri, Rosner, Thorsten, Markwalter, Chester E, Hsiao, Yi, Tran, Kristy, Eastgate, Martin D
Published in Journal of organic chemistry (19.04.2019)

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Journal Article

Two Approaches to a Trifluoromethyl Triazole: A Fit-for-Purpose Trifluoromethylation in Flow-Mode and a Long-Term Decarboxylative Click Approach

Two Approaches to a Trifluoromethyl Triazole: A Fit-for-Purpose Trifluoromethylation in Flow-Mode and a Long-Term Decarboxylative Click Approach

by Ayothiraman, Rajaram, Gangu, Aravind S, Bandaru, Durgarao, Guturi, Siva Krishna, Lakshminarasimhan, Thirumalai, Jaleel, Mohamed, Kanagavel, Kishorekumar, Rangaswamy, Sundaramurthy, Cuniere, Nicolas L, Zaretsky, Serge, Camacho, Kathryn, Eastgate, Martin D, Vaidyanathan, Rajappa
Published in Organic process research & development (21.02.2020)

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Development of a Practical Synthesis of Functionalized Azaxanthene-Derived Nonsteroidal Glucocorticoid Receptor Modulators

Development of a Practical Synthesis of Functionalized Azaxanthene-Derived Nonsteroidal Glucocorticoid Receptor Modulators

by Conlon, David A, Natalie, Kenneth J, Cuniere, Nicolas, Razler, Thomas M, Zhu, Jason, de Mas, Nuria, Tymonko, Steven, Fraunhoffer, Kenneth J, Sortore, Eric, Rosso, Victor W, Xu, Zhongmin, Adams, Monica L, Patel, Anisha, Huang, Jun, Gong, Hua, Weinstein, David S, Quiroz, Fernando, Chen, Doris C
Published in Organic process research & development (20.05.2016)

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Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain

Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain

by Wagschal, Simon, Broggini, Diego, Cao, Trung D.C., Schleiss, Pascal, Paun, Kristian, Steiner, Jessica, Merk, Anna-Lena, Harsdorf, Joachim, Fiedler, Winfried, Schirling, Stefan, Hock, Sven, Strittmatter, Tobias, Dijkmans, Jan, Vervest, Ivan, Van Hoegaerden, Tim, Egle, Brecht, Mower, Matthew P., Liu, Zhi, Cao, Zhiyong, He, Xiaoning, Chen, Lei, Qin, Lei, Tan, Hongyu, Yan, Jun, Cunière, Nicolas Lucien, Wei, Carolyn S., Vuyyuru, Venkata, Ayothiraman, Rajaram, Rangaswamy, Sundaramurthy, Jaleel, Mohamed, Vaidyanathan, Rajappa, Eastgate, Martin D., Klep, Richard, Benhaïm, Cyril, Vogels, Ilse, Peeters, Koen, Lemaire, Sébastien
Published in Organic process research & development (21.04.2023)

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Journal Article

Process Development of a Macrocyclic Peptide Inhibitor of PD-L1

Process Development of a Macrocyclic Peptide Inhibitor of PD-L1

by Mukherjee, Subha, Rogers, Amanda, Creech, Gardner, Hang, Chao, Ramirez, Antonio, Dummeldinger, Michael, Brueggemeier, Shawn, Mapelli, Claudio, Zaretsky, Serge, Huang, Masano, Black, Regina, Peddicord, Michael B., Cuniere, Nicolas, Kempson, James, Pawluczyk, Joseph, Allen, Martin, Parsons, Rodney, Sfouggatakis, Chris
Published in Journal of organic chemistry (17.05.2024)

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Journal Article

Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole

Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole

by Garlets, Zachary J., Yuill, Elizabeth M., Yang, Alice, Ye, Qingmei, Ding, Wei, Wood, Christopher, Fan, Junying, Cuniere, Nicolas Lucien, Sfouggatakis, Chris
Published in Organic process research & development (20.01.2023)

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Journal Article

The case for noncompetitive cyclizative options during attempted expedient construction of the core ring system of CP-263,114

The case for noncompetitive cyclizative options during attempted expedient construction of the core ring system of CP-263,114

by Cuniere, Nicolas, Paquette, Leo A.
Published in ARKIVOC (28.08.2000)

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Concise asymmetric synthesis of a (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid-derived sulfonamide and ethyl ester

Concise asymmetric synthesis of a (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid-derived sulfonamide and ethyl ester

by Lou, Sha, Cuniere, Nicolas, Su, Bao-Ning, Hobson, Lindsay A.
Published in Organic & biomolecular chemistry (21.10.2013)

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Journal Article

Concise asymmetric synthesis of a (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid-derived sulfonamide and ethyl esterElectronic supplementary information (ESI) available: 1H and 13C NMR spectra for compounds 1b, 2, 3, 4a and 8, and chiral HPLC chromatograms for 1b, 2, 3 and 4a. See DOI: 10.1039/c3ob41394b

Concise asymmetric synthesis of a (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid-derived sulfonamide and ethyl esterElectronic supplementary information (ESI) available: 1H and 13C NMR spectra for compounds 1b, 2, 3, 4a and 8, and chiral HPLC chromatograms for 1b, 2, 3 and 4a. See DOI: 10.1039/c3ob41394b

by Lou, Sha, Cuniere, Nicolas, Su, Bao-Ning, Hobson, Lindsay A
Year of Publication 18.09.2013

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Journal Article

Diastereoselectivity Control in the Zirconocene-Mediated Ring Contraction of 4-Vinylfuranosides to Enantiopure Multiply Functionalized Cyclobutanes

Diastereoselectivity Control in the Zirconocene-Mediated Ring Contraction of 4-Vinylfuranosides to Enantiopure Multiply Functionalized Cyclobutanes

by Paquette, Leo A, Cunière, Nicolas
Published in Organic letters (30.05.2002)

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Journal Article

Efficient and Scalable Enantioselective Synthesis of a CGRP Antagonist

Efficient and Scalable Enantioselective Synthesis of a CGRP Antagonist

by Leahy, David K, Fan, Yu, Desai, Lopa V, Chan, Collin, Zhu, Jason, Luo, Guanglin, Chen, Ling, Hanson, Ronald L, Sugiyama, Masano, Rosner, Thorsten, Cuniere, Nicolas, Guo, Zhiwei, Hsiao, Yi, Gao, Qi
Published in Organic letters (21.09.2012)

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Journal Article

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

by CUNIERE, Nicolas, VLAHOVA, Petinka I, SCHLAM, Roxana F, SHI, Zhongping, MBACHU, Victoria A
Year of Publication 28.04.2024

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Patent

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

by Shi, Zhongping, Mbachu, Victoria A, Vlahova, Petinka I, Schlam, Roxana F, Cuniere, Nicolas
Year of Publication 26.04.2024

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Patent

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

by CUNIERE, Nicolas, VLAHOVA, Petinka I, SCHLAM, Roxana F, SHI, Zhongping, MBACHU, Victoria A
Year of Publication 28.02.2024

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Patent

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

by SHI Zhongping, SCHLAM Roxana F, MBACHU Victoria A, VLAHOVA Petinka I, CUNIERE Nicolas
Year of Publication 29.12.2023

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Patent

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

by SCHLAM, ROXANA, F, SHI, ZHONGPING, MBACHU, VICTORIA, A, CUNIERE, NICOLAS, VLAHOVA, PETINKA, I
Year of Publication 29.12.2023

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Patent

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

by SHI, ZHONGPING, SCHLAM, ROXANA F, CUNIERE, NICOLAS, VLAHOVA, PETINKA I, MBACHU, VICTORIA A
Year of Publication 04.12.2023

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Patent

KRYSTALLINSKE FORMER AF EN PAR4-HÆMMER

KRYSTALLINSKE FORMER AF EN PAR4-HÆMMER

by CUNIERE, Nicolas, VLAHOVA, Petinka I, SCHLAM, Roxana F, SHI, Zhongping, MBACHU, Victoria A
Year of Publication 20.11.2023

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Patent

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

by CUNIERE, Nicolas, VLAHOVA, Petinka I, SCHLAM, Roxana F, SHI, Zhongping, MBACHU, Victoria A
Year of Publication 15.11.2023

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Patent

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

CRYSTALLINE FORMS OF A PAR4 INHIBITOR

by CUNIERE, Nicolas, VLAHOVA, Petinka I, SCHLAM, Roxana F, SHI, Zhongping, MBACHU, Victoria A
Year of Publication 10.11.2023

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Patent

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