Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy
Beauverger, Philippe, Ozoux, Marie-Laure, Bégis, Guillaume, Glénat, Valérie, Briand, Véronique, Philippo, Marie-Claire, Daveu, Cyril, Tavares, Georges, Roy, Sébastien, Corbier, Alain, Briand, Pascale, Dorchies, Olivier, Bauchet, Anne-Laure, Nicolai, Eric, Duclos, Olivier, Tamarelle, Dorothée, Pruniaux, Marie-Pierre, Muslin, Anthony J, Janiak, Philip
Published in Cardiovascular research (01.02.2020)
Published in Cardiovascular research (01.02.2020)
Get full text
Journal Article
Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1
Mougenot, Patrick, Namane, Claudie, Fett, Eykmar, Camy, Florence, Dadji-Faïhun, Rommel, Langot, Gwladys, Monseau, Catherine, Onofri, Bénédicte, Pacquet, François, Pascal, Cécile, Crespin, Olivier, Ben-Hassine, Majdi, Ragot, Jean-Luc, Van-Pham, Thao, Philippo, Christophe, Chatelain-Egger, Florence, Péron, Philippe, Le Bail, Jean-Christophe, Guillot, Etienne, Chamiot-Clerc, Philippe, Chabanaud, Marie-Aude, Pruniaux, Marie-Pierre, Schmidt, Friedemann, Venier, Olivier, Nicolaï, Eric, Viviani, Fabrice
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Get full text
Journal Article
Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D
Venier, Olivier, Pascal, Cécile, Braun, Alain, Namane, Claudie, Mougenot, Patrick, Crespin, Olivier, Pacquet, François, Mougenot, Cécile, Monseau, Catherine, Onofri, Bénédicte, Dadji-Faïhun, Rommel, Leger, Céline, Ben-Hassine, Majdi, Van-Pham, Thao, Ragot, Jean-Luc, Philippo, Christophe, Farjot, Géraldine, Noah, Lionel, Maniani, Karima, Boutarfa, Asma, Nicolaï, Eric, Guillot, Etienne, Pruniaux, Marie-Pierre, Güssregen, Stefan, Engel, Christian, Coutant, Anne-Laure, de Miguel, Beatriz, Castro, Antonio
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
Get full text
Journal Article
Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1
Venier, Olivier, Pascal, Cécile, Braun, Alain, Namane, Claudie, Mougenot, Patrick, Crespin, Olivier, Pacquet, François, Mougenot, Cécile, Monseau, Catherine, Onofri, Bénédicte, Dadji-Faïhun, Rommel, Leger, Céline, Ben-Hassine, Majdi, Van-Pham, Thao, Ragot, Jean-Luc, Philippo, Christophe, Güssregen, Stefan, Engel, Christian, Farjot, Géraldine, Noah, Lionel, Maniani, Karima, Nicolaï, Eric
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Get full text
Journal Article
Development and Validation of a Pharmacophore-Based QSAR Model for the Prediction of CNS Activity
Gozalbes, Rafael, Barbosa, Frédérique, Nicolaï, Eric, Horvath, Dragos, Froloff, Nicolas
Published in ChemMedChem (13.02.2009)
Published in ChemMedChem (13.02.2009)
Get full text
Journal Article
Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists
Nicolai, Eric, Goyard, Joel, Benchetrit, Thierry, Teulon, Jean Marie, Caussade, Francois, Virone, Angela, Delchambre, Chantal, Cloarec, Alix
Published in Journal of medicinal chemistry (01.04.1993)
Published in Journal of medicinal chemistry (01.04.1993)
Get full text
Journal Article
G-Protein-Coupled Receptor Affinity Prediction Based on the Use of a Profiling Dataset: QSAR Design, Synthesis, and Experimental Validation
Rolland, Catherine, Gozalbes, Rafael, Nicolaï, Eric, Paugam, Marie-France, Coussy, Laurent, Barbosa, Frédérique, Horvath, Dragos, Revah, Frédéric
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
Get full text
Journal Article
Synthesis and SAR Studies of Novel Triazolopyrimidine Derivatives as Potent, Orally Active Angiotensin II Receptor Antagonists
Nicolai, Eric, Cure, Gerard, Goyard, Joel, Kirchner, Maud, Teulon, Jean-Marie, Versigny, Annie, Cazes, Michele, Caussade, Francois, Virone-Oddos, Angela, Cloarec, Alix
Published in Journal of medicinal chemistry (01.07.1994)
Published in Journal of medicinal chemistry (01.07.1994)
Get full text
Journal Article
신규한 치환 6,7-디히드로-5H-벤조[7]아눌렌 유도체, 이의 제조 방법 및 이의 치료적 용도
BIANCIOTTO MARC, CERTAL VICTOR, BERNARDELLI PATRICK, PERIERS ANNE MARIE, EL AHMAD YOUSSEF, NICOLAI ERIC, TERRIER CORINNE, SLOWINSKI FRANCK, MOUGENOT PATRICK, DE BRUIN BEATRICE, PETIT FREDERIC, HALLEY FRANK, DA ROCHA ALICE
Year of Publication 26.06.2023
Get full text
Year of Publication 26.06.2023
Patent
OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES
NAMANE CLAUDIE, NICOLAI ERIC, FETT EYKMAR, MOUGENOT PATRICK, VENIER OLIVIER
Year of Publication 05.08.2016
Get full text
Year of Publication 05.08.2016
Patent
Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors
Mougenot, Patrick, Namane, Claudie, Fett, Eykmar, Goumy, Florence, Dadji-Faïhun, Rommel, Langot, Gwladys, Monseau, Catherine, Onofri, Bénédicte, Pacquet, François, Pascal, Cécile, Crespin, Olivier, Ben-Hassine, Majdi, Ragot, Jean-Luc, Van-Pham, Thao, Philippo, Christophe, Chatelain-Egger, Florence, Péron, Philippe, Le Bail, Jean-Christophe, Guillot, Etienne, Chamiot-Clerc, Philippe, Chabanaud, Marie-Aude, Pruniaux, Marie-Pierre, Ménegotto, Jérôme, Schmidt, Friedemann, Venier, Olivier, Viviani, Fabrice, Nicolai, Eric
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Get full text
Journal Article
Synthesis and Angiotensin II Receptor Antagonist Activity of C-Linked Pyrazole Derivatives
NICOLAI, Eric, CURE, Gerard, GOYARD, Joel, KIRCHNER, Maud, TEULON, Jean-Marie, VERSIGNY, Annie, CAZES, Michele, VIRONE-ODDOS, Angela, CAUSSADE, Francois, CLOAREC, Alix
Published in Chemical & pharmaceutical bulletin (1994)
Published in Chemical & pharmaceutical bulletin (1994)
Get full text
Journal Article
Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors
Rankovic, Zoran, Cai, Jiaqiang, Kerr, Jennifer, Fradera, Xavier, Robinson, John, Mistry, Ashvin, Hamilton, Emma, McGarry, George, Andrews, Fiona, Caulfield, Wilson, Cumming, Iain, Dempster, Maureen, Waller, John, Scullion, Paul, Martin, Iain, Mitchell, Ann, Long, Clive, Baugh, Mark, Westwood, Paul, Kinghorn, Emma, Bruin, John, Hamilton, William, Uitdehaag, Joost, Zeeland, Mario van, Potin, Dominique, Saniere, Laurent, Fouquet, Andre, Chevallier, François, Deronzier, Hortense, Dorleans, Cecile, Nicolai, Eric
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Get full text
Journal Article
DERIVATIVES OF OXADIAZOLE AND PYRIDAZINE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
NAMANE CLAUDIE, NICOLAI ERIC, FETT EYKMAR, MOUGENOT PATRICK, PHILIPPO CHRISTOPHE
Year of Publication 24.04.2013
Get full text
Year of Publication 24.04.2013
Patent
Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1
Potin, Dominique, Launay, Michele, Monatlik, Francoise, Malabre, Patrice, Fabreguettes, Maud, Fouquet, Andre, Maillet, Magali, Nicolai, Eric, Dorgeret, Loïc, Chevallier, François, Besse, Dominique, Dufort, Monique, Caussade, François, Ahmad, Syed Z, Stetsko, Dawn K, Skala, Stacey, Davis, Patricia M, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Postelneck, Jennifer, Townsend, Robert M, Goldfarb, Valentina, Sheriff, Steven, Einspahr, Howard, Kish, Kevin, Malley, Mary F, DiMarco, John D, Gougoutas, Jack Z, Kadiyala, Pathanjali, Cheney, Daniel L, Tejwani, Ravindra W, Murphy, Denette K, Mcintyre, Kim W, Yang, Xiaoxia, Chao, Sam, Leith, Leslie, Xiao, Zili, Mathur, Arvind, Chen, Bang-Chi, Wu, Daugh-Rurng, Traeger, Sarah C, McKinnon, Murray, Barrish, Joel C, Robl, Jeffrey A, Iwanowicz, Edwin J, Suchard, Suzanne J, Dhar, T. G. Murali
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
Get full text
Journal Article
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Cai, Jiaqiang, Bennett, D. Jonathan, Rankovic, Zoran, Dempster, Maureen, Fradera, Xavier, Gillespie, Jonathan, Cumming, Iain, Finlay, William, Baugh, Mark, Boucharens, Sylviane, Bruin, John, Cameron, Kenneth S., Hamilton, William, Kerr, Jennifer, Kinghorn, Emma, McGarry, George, Robinson, John, Scullion, Paul, Uitdehaag, Joost C.M., van Zeeland, Mario, Potin, Dominique, Saniere, Laurent, Fouquet, Andre, Chevallier, Francois, Deronzier, Hortense, Dorleans, Cecile, Nicolai, Eric
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
NAMANE CLAUDIE, NICOLAI ERIC, FETT EYKMAR, MOUGENOT PATRICK, PHILIPPO CHRISTOPHE
Year of Publication 13.10.2011
Get full text
Year of Publication 13.10.2011
Patent
PYRIMIDOOXAZOCINE DERIVATIVES AS MTOR-INHIBITORS
VIVIANI FABRICE, FORICHER YANN, NICOLAI ERIC, PASCAL CECILE, VIVET BERTRAND, MARCINIAK GILBERT, CRESPIN OLIVIER, MUZET NICOLAS, BRAUN ALAIN
Year of Publication 28.10.2014
Get full text
Year of Publication 28.10.2014
Patent
Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG
Rankovic, Zoran, Cai, Jiaqiang, Kerr, Jennifer, Fradera, Xavier, Robinson, John, Mistry, Ashvin, Finlay, William, McGarry, George, Andrews, Fiona, Caulfield, Wilson, Cumming, Iain, Dempster, Maureen, Waller, John, Arbuckle, Wullie, Anderson, Mark, Martin, Iain, Mitchell, Ann, Long, Clive, Baugh, Mark, Westwood, Paul, Kinghorn, Emma, Jones, Phil, Uitdehaag, Joost C.M., van Zeeland, Mario, Potin, Dominique, Saniere, Laurent, Fouquet, Andre, Chevallier, François, Deronzier, Hortense, Dorleans, Cecile, Nicolai, Eric
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Get full text
Journal Article