Identification of Small Molecules that Modulate Mutant p53 Condensation
Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick
Published in iScience (25.09.2020)
Published in iScience (25.09.2020)
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Journal Article
Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N‑[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile
Werner, Stefan, Mesch, Stefanie, Hillig, Roman C, ter Laak, Antonius, Klint, Julie, Neagoe, Ioana, Laux-Biehlmann, Alexis, Dahllöf, Henrik, Bräuer, Nico, Puetter, Vera, Nubbemeyer, Reinhard, Schulz, Simone, Bairlein, Michaela, Zollner, Thomas M, Steinmeyer, Andreas
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Journal Article
Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers
Davenport, Adam J, Neagoe, Ioana, Bräuer, Nico, Koch, Markus, Rotgeri, Andrea, Nagel, Jens, Laux-Biehlmann, Alexis, Machet, Frederic, Coelho, Anne-Marie, Boyce, Susan, Carty, Nikisha, Gemkow, Mark J, Hess, Stephen D, Zollner, Thomas M, Fischer, Oliver M
Published in Scientific reports (06.10.2021)
Published in Scientific reports (06.10.2021)
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Journal Article
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A
Wortmann, Lars, Bräuer, Nico, Holton, Simon J, Irlbacher, Horst, Weiske, Jörg, Lechner, Christian, Meier, Robin, Karén, Jakob, Siöberg, Catrine Berthold, Pütter, Vera, Christ, Clara D, ter Laak, Antonius, Lienau, Philip, Lesche, Ralf, Nicke, Barbara, Cheung, Shing-Hu, Bauser, Marcus, Haegebarth, Andrea, von Nussbaum, Franz, Mumberg, Dominik, Lemos, Clara
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Journal Article
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Weiske, Joerg, Kuehnlenz, Julia, Brzezinka, Krzysztof, Potze, Lisette, Zanconato, Francesca, Nicke, Barbara, Montebaur, Anna, Bone, Wilhelm, Golfier, Sven, Kaulfuss, Stefan, Kopitz, Charlotte, Pilari, Sabine, Steuber, Holger, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Braeuer, Nico, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, von Nussbaum, Franz, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin
Published in Cell chemical biology (18.07.2024)
Published in Cell chemical biology (18.07.2024)
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Journal Article
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis
Koppitz, Marcus, Bräuer, Nico, Ter Laak, Antonius, Irlbacher, Horst, Rotgeri, Andrea, Coelho, Anne-Marie, Walter, Daryl, Steinmeyer, Andreas, Zollner, Thomas M., Peters, Michaele, Nagel, Jens
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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Journal Article
Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
Bäurle, Stefan, Nagel, Jens, Peters, Olaf, Bräuer, Nico, ter Laak, Antonius, Preusse, Cornelia, Rottmann, Antje, Heldmann, Dieter, Bothe, Ulrich, Blume, Thorsten, Zorn, Ludwig, Walter, Daryl, Zollner, Thomas M, Steinmeyer, Andreas, Langer, Gernot
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
Abstract 4584: Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I and Rho-GTPase signaling
Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Nicke, Barbara, Bone, Wilhelm, Golfier, Sven, Brzezinka, Krzysztof, Kaulfuss, Stefan, Kopitz, Charlotte, Steuber, Holger, Braeuer, Nico, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Kuehnlenz, Julia, Potze, Lisette, Zanconato, Francesca, Montebaur, Anna, Pilari, Sabine, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
ANDREA ROTGERI, NICO BRAEUER, IOANA NEAGOE, JENS NAGEL, ADAM JAMES DAVENPORT, ANNE-MARIE GODINHO-COELHO, OLIVER MARTIN FISCHER, ANTJE ROTTMANN
Year of Publication 18.04.2019
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Year of Publication 18.04.2019
Patent
1,3-thiazol-2-yl substituted benzamides
Godinho-Coelho, Anne-Marie, Fischer, Oliver Martin, Davenport, Adam James, Nagel, Jens, Neagoe, Ioana, Klar, Juergen, Braeuer, Nico, Rotgeri, Andrea, Rottmann, Antje
Year of Publication 25.03.2022
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Year of Publication 25.03.2022
Patent
1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
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Year of Publication 13.12.2021
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Year of Publication 13.12.2021
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1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
NEAGOE, IOANA, GODINHO-COELHO, ANNE-MARIE, KLAR, JUERGEN, DAVENPORT, ADAM JAMES, FISCHER, OLIVER MARTIN, NAGEL, JENS, BRAEUER, NICO, ROTGERI, ANDREA, ROTTMANN, ANTJE
Year of Publication 30.09.2021
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Year of Publication 30.09.2021
Patent
1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
Godinho-Coelho, Anne-Marie, Fischer, Oliver Martin, Davenport, Adam James, Nagel, Jens, Neagoe, Ioana, Klar, Juergen, Braeuer, Nico, Rotgeri, Andrea, Rottmann, Antje
Year of Publication 17.09.2021
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Year of Publication 17.09.2021
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1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
DAVENPORT Adam James, KLAR Juergen, FISCHER Oliver Martin, NAGEL Jens, BRAEUER Nico, ROTGERI Andrea, ROTTMANN Antje, NEAGOE Ioana, GODINHO-COELHO Anne-Marie
Year of Publication 31.08.2021
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Year of Publication 31.08.2021
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1,3-THIAZOL-2-YL-SUBSTITUEREDE BENZAMIDER
GODINHO-COELHO, Anne-Marie, FISCHER, Oliver Martin, ROTGERI, Andrea, NAGEL, Jens, BRAEUER, Nico, NEAGOE, Ioana, DAVENPORT, Adam James, ROTTMANN, Antje, KLAR, Juergen
Year of Publication 16.08.2021
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Year of Publication 16.08.2021
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1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
GODINHO-COELHO, Anne-Marie, FISCHER, Oliver Martin, ROTGERI, Andrea, NAGEL, Jens, BRAEUER, Nico, NEAGOE, Ioana, DAVENPORT, Adam James, ROTTMANN, Antje, KLAR, Juergen
Year of Publication 12.07.2021
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Year of Publication 12.07.2021
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1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
GODINHO-COELHO, Anne-Marie, FISCHER, Oliver Martin, ROTGERI, Andrea, NAGEL, Jens, BRAEUER, Nico, NEAGOE, Ioana, DAVENPORT, Adam James, ROTTMANN, Antje, KLAR, Juergen
Year of Publication 26.05.2021
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Year of Publication 26.05.2021
Patent
1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
GODINHO-COELHO, Anne-Marie, FISCHER, Oliver Martin, ROTGERI, Andrea, NAGEL, Jens, BRAEUER, Nico, NEAGOE, Ioana, DAVENPORT, Adam James, ROTTMANN, Antje, Juergen Klar
Year of Publication 28.01.2021
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Year of Publication 28.01.2021
Patent