Discovery of I‑BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
Theodoulou, Natalie H, Bamborough, Paul, Bannister, Andrew J, Becher, Isabelle, Bit, Rino A, Che, Ka Hing, Chung, Chun-wa, Dittmann, Antje, Drewes, Gerard, Drewry, David H, Gordon, Laurie, Grandi, Paola, Leveridge, Melanie, Lindon, Matthew, Michon, Anne-Marie, Molnar, Judit, Robson, Samuel C, Tomkinson, Nicholas C. O, Kouzarides, Tony, Prinjha, Rab K, Humphreys, Philip G
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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The endoplasmic reticulum–localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
Salaun, Christine, Tomkinson, Nicholas C.O., Chamberlain, Luke H.
Published in The Journal of biological chemistry (01.10.2023)
Published in The Journal of biological chemistry (01.10.2023)
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Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry
Greaves, Jennifer, Munro, Kevin R., Davidson, Stuart C., Riviere, Matthieu, Wojno, Justyna, Smith, Terry K., Tomkinson, Nicholas C. O., Chamberlain, Luke H.
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2017)
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Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH
Wilson, Liam T, Tipping, William J, Wetherill, Corinna, Henley, Zoë, Faulds, Karen, Graham, Duncan, Mackay, Simon P, Tomkinson, Nicholas C. O
Published in Analytical chemistry (Washington) (21.09.2021)
Published in Analytical chemistry (Washington) (21.09.2021)
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A direct-to-biology high-throughput chemistry approach to reactive fragment screening
Thomas, Ross P, Heap, Rachel E, Zappacosta, Francesca, Grant, Emma K, Pogány, Peter, Besley, Stephen, Fallon, David J, Hann, Michael M, House, David, Tomkinson, Nicholas C. O, Bush, Jacob T
Published in Chemical science (Cambridge) (22.09.2021)
Published in Chemical science (Cambridge) (22.09.2021)
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A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy
Wilson, Liam T, Tipping, William J, Jamieson, Lauren E, Wetherill, Corinna, Henley, Zoë, Faulds, Karen, Graham, Duncan, Mackay, Simon P, Tomkinson, Nicholas C. O
Published in Analyst (London) (07.08.2020)
Published in Analyst (London) (07.08.2020)
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Synthesis, characterisation and multi-modal intracellular mapping of cisplatin nano-conjugates
Leventi, Aristea Anna, Braddick, Henry J, Billimoria, Kharmen, Wallace, Gregory Q, Goenaga-Infante, Heidi, Tomkinson, Nicholas C.O, Faulds, Karen, Graham, Duncan
Published in Chemical communications (Cambridge, England) (23.05.2023)
Published in Chemical communications (Cambridge, England) (23.05.2023)
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Stimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug-cell interactions
Tipping, William J, Wilson, Liam T, An, Connie, Leventi, Aristea A, Wark, Alastair W, Wetherill, Corinna, Tomkinson, Nicholas C. O, Faulds, Karen, Graham, Duncan
Published in Chemical science (Cambridge) (24.03.2022)
Published in Chemical science (Cambridge) (24.03.2022)
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A Photoaffinity Displacement Assay and Probes to Study the Cyclin‐Dependent Kinase Family
Grant, Emma K., Fallon, David J., Eberl, H. Christian, Fantom, Ken G. M., Zappacosta, Francesca, Messenger, Cassie, Tomkinson, Nicholas C. O., Bush, Jacob T.
Published in Angewandte Chemie International Edition (25.11.2019)
Published in Angewandte Chemie International Edition (25.11.2019)
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A Photoaffinity‐Based Fragment‐Screening Platform for Efficient Identification of Protein Ligands
Grant, Emma K., Fallon, David J., Hann, Michael M., Fantom, Ken G. M., Quinn, Chad, Zappacosta, Francesca, Annan, Roland S., Chung, Chun‐wa, Bamborough, Paul, Dixon, David P., Stacey, Peter, House, David, Patel, Vipulkumar K., Tomkinson, Nicholas C. O., Bush, Jacob T.
Published in Angewandte Chemie International Edition (16.11.2020)
Published in Angewandte Chemie International Edition (16.11.2020)
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Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation
Pariollaud, Marie, Gibbs, Julie E, Hopwood, Thomas W, Brown, Sheila, Begley, Nicola, Vonslow, Ryan, Poolman, Toryn, Guo, Baoqiang, Saer, Ben, Jones, D Heulyn, Tellam, James P, Bresciani, Stefano, Tomkinson, Nicholas Co, Wojno-Picon, Justyna, Cooper, Anthony Wj, Daniels, Dion A, Trump, Ryan P, Grant, Daniel, Zuercher, William, Willson, Timothy M, MacDonald, Andrew S, Bolognese, Brian, Podolin, Patricia L, Sanchez, Yolanda, Loudon, Andrew Si, Ray, David W
Published in The Journal of clinical investigation (01.06.2018)
Published in The Journal of clinical investigation (01.06.2018)
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Alkene Syn- and Anti-Oxyamination with Malonoyl Peroxides
Curle, Jonathan M, Perieteanu, Marina C, Humphreys, Philip G, Kennedy, Alan R, Tomkinson, Nicholas C. O
Published in Organic letters (21.02.2020)
Published in Organic letters (21.02.2020)
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Expanding the Range of Bioorthogonal Tags for Multiplex Stimulated Raman Scattering Microscopy
Murphy, Neville, Tipping, William J., Braddick, Henry J., Wilson, Liam T., Tomkinson, Nicholas C. O., Faulds, Karen, Graham, Duncan, Farràs, Pau
Published in Angewandte Chemie International Edition (27.11.2023)
Published in Angewandte Chemie International Edition (27.11.2023)
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Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation
Salaun, Christine, Takizawa, Hiroya, Galindo, Alex, Munro, Kevin R., McLellan, Jayde, Sugimoto, Isamu, Okino, Tomotaka, Tomkinson, Nicholas C.O., Chamberlain, Luke H.
Published in The Journal of biological chemistry (01.10.2022)
Published in The Journal of biological chemistry (01.10.2022)
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Detection of Heterogeneous Protein S-Acylation in Cells
Greaves, Jennifer, Tomkinson, Nicholas C O
Published in Methods in molecular biology (Clifton, N.J.) (2019)
Published in Methods in molecular biology (Clifton, N.J.) (2019)
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