Distribution analysis of epertinib in brain metastasis of HER2-positive breast cancer by imaging mass spectrometry and prospect for antitumor activity
Tanaka, Yukari, Hirata, Michinari, Shinonome, Satomi, Torii, Mikinori, Nezasa, Ken-ichi, Tanaka, Hidekazu
Published in Scientific reports (10.01.2018)
Published in Scientific reports (10.01.2018)
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Using Improved Serial Blood Sampling Method of Mice to Study Pharmacokinetics and Drug–Drug Interaction
Watanabe, Ayahisa, Watari, Ryosuke, Ogawa, Keiko, Shimizu, Ryosuke, Tanaka, Yukari, Takai, Nozomi, Nezasa, Ken-Ichi, Yamaguchi, Yoshitaka
Published in Journal of pharmaceutical sciences (01.03.2015)
Published in Journal of pharmaceutical sciences (01.03.2015)
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Preclinical antitumor activity of S‐222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2
Tanaka, Hidekazu, Hirata, Michinari, Shinonome, Satomi, Wada, Toru, Iguchi, Motofumi, Dohi, Keiji, Inoue, Makiko, Ishioka, Yukichi, Hojo, Kanji, Yamada, Tomomi, Sugimoto, Tatsuya, Masuno, Koichi, Nezasa, Ken‐ichi, Sato, Norihito, Matsuo, Kenji, Yonezawa, Shuji, Frenkel, Eugene P., Shichijo, Michitaka
Published in Cancer science (01.08.2014)
Published in Cancer science (01.08.2014)
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Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
Zamek-Gliszczynski, Maciej J., Hoffmaster, Keith A., Nezasa, Ken-ichi, Tallman, Melanie N., Brouwer, Kim L.R.
Published in European journal of pharmaceutical sciences (01.04.2006)
Published in European journal of pharmaceutical sciences (01.04.2006)
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The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice
Zamek-Gliszczynski, Maciej J, Nezasa, Ken-Ichi, Tian, Xianbin, Kalvass, J Cory, Patel, Nita J, Raub, Thomas J, Brouwer, Kim L R
Published in Molecular pharmacology (01.12.2006)
Published in Molecular pharmacology (01.12.2006)
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Differential Involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in Biliary Excretion of 4-Methylumbelliferyl Glucuronide and Sulfate in the Rat
Zamek-Gliszczynski, Maciej J, Hoffmaster, Keith A, Humphreys, Joan E, Tian, Xianbin, Nezasa, Ken-Ichi, Brouwer, Kim L R
Published in The Journal of pharmacology and experimental therapeutics (01.10.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2006)
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Multidrug Resistance-Associated Protein 2 Is Primarily Responsible for the Biliary Excretion of Fexofenadine in Mice
XIANBIN TIAN, ZAMEK-GLISZCZYNSKI, Maciej J, JUN LI, BRIDGES, Arlene S, NEZASA, Ken-Ichi, PATEL, Nita J, RAUB, Thomas J, BROUWER, Kim L. R
Published in Drug metabolism and disposition (01.01.2008)
Published in Drug metabolism and disposition (01.01.2008)
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Liver-Specific Distribution of Rosuvastatin in Rats: Comparison with Pravastatin and Simvastatin
NEZASA, Ken-Ichi, HIGAKI, Kazutaka, MATSUMURA, Tadahiko, INAZAWA, Kazuhiro, HASEGAWA, Hiroshi, NAKANO, Masayuki, KOIKE, Masahiro
Published in Drug metabolism and disposition (01.11.2002)
Published in Drug metabolism and disposition (01.11.2002)
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Journal Article
Improved Human Pharmacokinetic Prediction of Hepatically Metabolized Drugs With Species-Specific Systemic Clearance
Horiuchi, Kana, Ohnishi, Shuichi, Matsuzaki, Takanobu, Funaki, Satoko, Watanabe, Ayahisa, Mizutare, Tohru, Matsumoto, Sayaka, Nezasa, Ken-ichi, Hasegawa, Hiroshi
Published in Journal of pharmaceutical sciences (01.05.2018)
Published in Journal of pharmaceutical sciences (01.05.2018)
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Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice
Zamek-Gliszczynski, Maciej J, Nezasa, Ken-ichi, Tian, Xianbin, Bridges, Arlene S, Lee, Kun, Belinsky, Martin G, Kruh, Gary D, Brouwer, Kim L R
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice
NEZASA, Ken-Ichi, XIANBIN TIAN, ZAMEK-GLISZCZYNSKI, Maciej J, PATEL, Nita J, RAUB, Thomas J, BROUWER, Kim L. R
Published in Drug metabolism and disposition (01.04.2006)
Published in Drug metabolism and disposition (01.04.2006)
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Journal Article
Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR−) Wistar rats
Leslie, Elaine M., Ghibellini, Giulia, Nezasa, Ken-ichi, Brouwer, Kim L.R.
Published in Carcinogenesis (New York) (01.12.2007)
Published in Carcinogenesis (New York) (01.12.2007)
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Abstract 4073: Antitumor activities of EGFR/HER2/HER4 kinase inhibitor S-222611 in the experimental brain metastases of HER2-positive breast cancer
Hirata, Michinari, Tanaka, Yukari, Shinonome, Satomi, Yamada, Tomomi, Torii, Mikinori, Nezasa, Ken-ichi, Tanaka, Hidekazu
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 4085: Distribution analysis of S-222611 in brain metastases of HER2-positive breast cancer by quantitative imaging mass spectrometry: prospect for antitumor activity of EGFR/HER2/HER4 kinase inhibitor S-222611 against brain metastases
Tanaka, Yukari, Hirata, Michinari, Shinonome, Satomi, Matsumoto, Mitsunobu, Nogami, Wataru, Torii, Mikinori, Nezasa, Ken-ichi, Tanaka, Hidekazu
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
S‐222611, an oral reversible tyrosine kinase inhibitor of EGFR and HER2. A representative histological image of the colon treated with S‐222611 (25 mg/kg)
Tanaka, Hidekazu, Hirata, Michinari, Shinonome, Satomi, Wada, Toru, Iguchi, Motofumi, Dohi, Keiji, Inoue, Makiko, Ishioka, Yukichi, Hojo, Kanji, Yamada, Tomomi, Sugimoto, Tatsuya, Masuno, Koichi, Nezasa, Ken‐ichi, Sato, Norihito, Matsuo, Kenji, Yonezawa, Shuji, Frenkel, Eugene P., Shichijo, Michitaka
Published in Cancer science (01.08.2014)
Published in Cancer science (01.08.2014)
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Journal Article
Mechanisms of harmol sulfate biliary excretion in mice and rats
Zamek-Gliszczynski, Maciej J., Hoffmaster, Keith A., Nezasa, Ken-ichi, Brouwer, Kim L. R.
Published in Drug metabolism and disposition (21.08.2008)
Published in Drug metabolism and disposition (21.08.2008)
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Journal Article
Using Improved Serial Blood Sampling Method of Mice to Study Pharmacokinetics and Drug-Drug Interaction
Watanabe, Ayahisa, Watari, Ryosuke, Ogawa, Keiko, Shimizu, Ryosuke, Tanaka, Yukari, Takai, Nozomi, Nezasa, Ken-Ichi, Yamaguchi, Yoshitaka
Published in Journal of pharmaceutical sciences (01.03.2015)
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Published in Journal of pharmaceutical sciences (01.03.2015)
Journal Article
Evaluation of the Role of Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 in Hepatic Basolateral Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Abcc3â/â and Abcc4â/â Mice
Maciej J. Zamek-Gliszczynski, Ken-ichi Nezasa, Xianbin Tian, Arlene S. Bridges, Kun Lee, Martin G. Belinsky, Gary D. Kruh, Kim L. R. Brouwer
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Journal Article