Search Results - "NEWTON, Roger S" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

by Pinkosky, Stephen L, Newton, Roger S, Day, Emily A, Ford, Rebecca J, Lhotak, Sarka, Austin, Richard C, Birch, Carolyn M, Smith, Brennan K, Filippov, Sergey, Groot, Pieter H E, Steinberg, Gregory R, Lalwani, Narendra D
Published in Nature communications (28.11.2016)

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AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism[S]

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism[S]

by Pinkosky, Stephen L., Filippov, Sergey, Srivastava, Rai Ajit K., Hanselman, Jeffrey C., Bradshaw, Cheryl D., Hurley, Timothy R., Cramer, Clay T., Spahr, Mark A., Brant, Ashley F., Houghton, Jacob L., Baker, Chris, Naples, Mark, Adeli, Khosrow, Newton, Roger S.
Published in Journal of lipid research (01.01.2013)

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Efficacy and Safety of a Novel Dual Modulator of Adenosine Triphosphate-Citrate Lyase and Adenosine Monophosphate-Activated Protein Kinase in Patients With Hypercholesterolemia

Efficacy and Safety of a Novel Dual Modulator of Adenosine Triphosphate-Citrate Lyase and Adenosine Monophosphate-Activated Protein Kinase in Patients With Hypercholesterolemia

by Ballantyne, Christie M., MD, Davidson, Michael H., MD, MacDougall, Diane E., MS, Bays, Harold E., MD, DiCarlo, Lorenzo A., MD, Rosenberg, Noah L., MD, Margulies, Janice, MS, Newton, Roger S., PhD
Published in Journal of the American College of Cardiology (24.09.2013)

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Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance

Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance

by Thompson, Paul D., MD, Rubino, John, MD, Janik, Matthew J., MD, MacDougall, Diane E., MS, McBride, Scott J., MA, Margulies, Janice R., MS, Newton, Roger S., PhD
Published in Journal of clinical lipidology (01.05.2015)

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Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance

Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance

by Thompson, Paul D., MD, MacDougall, Diane E., MS, Newton, Roger S., PhD, Margulies, Janice R., MS, Hanselman, Jeffrey C., MS, Orloff, David G., MD, McKenney, James M., PharmD, Ballantyne, Christie M., MD
Published in Journal of clinical lipidology (01.05.2016)

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ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

by Filippov, Sergey, Pinkosky, Stephen L., Lister, Richard J., Pawloski, Catherine, Hanselman, Jeffrey C., Cramer, Clay T., Srivastava, Rai Ajit K., Hurley, Timothy R., Bradshaw, Cheryl D., Spahr, Mark A., Newton, Roger S.
Published in Journal of lipid research (01.08.2013)

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AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

by Srivastava, Rai Ajit K., Pinkosky, Stephen L., Filippov, Sergey, Hanselman, Jeffrey C., Cramer, Clay T., Newton, Roger S.
Published in Journal of lipid research (01.12.2012)

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Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants

Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants

by Aviram, Michael, Rosenblat, Mira, Billecke, Scott, Erogul, John, Sorenson, Robert, Bisgaier, Charles L, Newton, Roger S, La Du, Bert
Published in Free radical biology & medicine (01.04.1999)

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Bayesian network analysis of panomic biological big data identifies the importance of triglyceride-rich LDL in atherosclerosis development

Bayesian network analysis of panomic biological big data identifies the importance of triglyceride-rich LDL in atherosclerosis development

by Voros, Szilard, Bansal, Aruna T, Barnes, Michael R, Narula, Jagat, Maurovich-Horvat, Pal, Vazquez, Gustavo, Marvasty, Idean B, Brown, Bradley O, Voros, Isaac D, Harris, William, Voros, Viktor, Dayspring, Thomas, Neff, David, Greenfield, Alex, Furchtgott, Leon, Church, Bruce, Runge, Karl, Khalil, Iya, Hayete, Boris, Lucero, Diego, Remaley, Alan T, Newton, Roger S
Published in Frontiers in cardiovascular medicine (04.01.2023)

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Efficacy and Safety of a Novel Dual Modulator of Adenosine Triphosphate-Citrate Lyase and Adenosine Monophosphate-Activated Protein Kinase in Patients With Hypercholesterolemia: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

Efficacy and Safety of a Novel Dual Modulator of Adenosine Triphosphate-Citrate Lyase and Adenosine Monophosphate-Activated Protein Kinase in Patients With Hypercholesterolemia: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

by BALLANTYNE, Christie M, DAVIDSON, Michael H, MACDOUGALL, Diane E, BAYS, Harold E, DICARLO, Lorenzo A, ROSENBERG, Noah L, MARGULIES, Janice, NEWTON, Roger S
Published in Journal of the American College of Cardiology (24.09.2013)

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Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol–Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus

Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol–Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus

by Gutierrez, Maria J, Rosenberg, Noah L, MacDougall, Diane E, Hanselman, Jeffrey C, Margulies, Janice R, Strange, Poul, Milad, Mark A, McBride, Scott J, Newton, Roger S
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2014)

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Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr−/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid

Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr−/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid

by Samsoondar, Joshua P, Burke, Amy C, Sutherland, Brian G, Telford, Dawn E, Sawyez, Cynthia G, Edwards, Jane Y, Pinkosky, Stephen L, Newton, Roger S, Huff, Murray W
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2017)

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Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient (LDLR+/− and LDLR−/−) Yucatan Miniature Pigs

Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient (LDLR+/− and LDLR−/−) Yucatan Miniature Pigs

by Burke, Amy C, Telford, Dawn E, Sutherland, Brian G, Edwards, Jane Y, Sawyez, Cynthia G, Barrett, P. Hugh R, Newton, Roger S, Pickering, J Geoffrey, Huff, Murray W
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2018)

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LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

by Filippov, Sergey, Pinkosky, Stephen L, Newton, Roger S
Published in Current opinion in lipidology (01.08.2014)

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Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism

Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism

by Srivastava, Rai Ajit K., Hurley, Timothy R., Oniciu, Daniela, Adeli, Khosrow, Newton, Roger S.
Published in Nutrition, metabolism, and cardiovascular diseases (22.07.2021)

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Corrigendum to “Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism” [Nutr Metabol Cardiovasc Dis 31 (2021) 2490–2703]

Corrigendum to “Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism” [Nutr Metabol Cardiovasc Dis 31 (2021) 2490–2703]

by Srivastava, Rai Ajit K., Hurley, Timothy R., Oniciu, Daniela, Adeli, Khosrow, Newton, Roger S.
Published in Nutrition, metabolism, and cardiovascular diseases (01.01.2022)

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Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs

Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs

by Burnett, J R, Wilcox, L J, Telford, D E, Kleinstiver, S J, Barrett, P H, Newton, R S, Huff, M W
Published in Journal of lipid research (01.07.1999)

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Dose-Related Effects of Repeated ETC-216 (Recombinant Apolipoprotein A-IMilano /1-Palmitoyl-2-Oleoyl Phosphatidylcholine Complexes) Administrations on Rabbit Lipid-Rich Soft Plaques

Dose-Related Effects of Repeated ETC-216 (Recombinant Apolipoprotein A-IMilano /1-Palmitoyl-2-Oleoyl Phosphatidylcholine Complexes) Administrations on Rabbit Lipid-Rich Soft Plaques

by Parolini, Cinzia, PhD, Marchesi, Marta, PhD, Lorenzon, Paolo, Castano, Mauro, PhD, Balconi, Elena, BS, Miragoli, Luigi, Chaabane, Linda, PhD, Morisetti, Alberto, BS, Lorusso, Vito, BS, Martin, Bradley J., PhD, Bisgaier, Charles L., PhD, Krause, Brian, PhD, Newton, Roger S., PhD, Sirtori, Cesare R., MD, PhD, Chiesa, Giulia, PhD
Published in Journal of the American College of Cardiology (01.03.2008)

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Dose-related effects of repeated ETC-216 (recombinant apolipoprotein A-I Milano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes) administrations on rabbit lipid-rich soft plaques: in vivo assessment by intravascular ultrasound and magnetic resonance imaging

Dose-related effects of repeated ETC-216 (recombinant apolipoprotein A-I Milano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes) administrations on rabbit lipid-rich soft plaques: in vivo assessment by intravascular ultrasound and magnetic resonance imaging

by Parolini, Cinzia, Marchesi, Marta, Lorenzon, Paolo, Castano, Mauro, Balconi, Elena, Miragoli, Luigi, Chaabane, Linda, Morisetti, Alberto, Lorusso, Vito, Martin, Bradley J, Bisgaier, Charles L, Krause, Brian, Newton, Roger S, Sirtori, Cesare R, Chiesa, Giulia
Published in Journal of the American College of Cardiology (18.03.2008)

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Inhibition of HMG-CoA Reductase by Atorvastatin Decreases Both VLDL and LDL Apolipoprotein B Production in Miniature Pigs

Inhibition of HMG-CoA Reductase by Atorvastatin Decreases Both VLDL and LDL Apolipoprotein B Production in Miniature Pigs

by Burnett, John R, Wilcox, Lisa J, Telford, Dawn E, Kleinstiver, Sandra J, Barrett, P. Hugh R, Newton, Roger S, Huff, Murray W
Published in Arteriosclerosis, thrombosis, and vascular biology (01.11.1997)

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