GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1
Balazova, Lucia, Balaz, Miroslav, Horvath, Carla, Horváth, Áron, Moser, Caroline, Kovanicova, Zuzana, Ghosh, Adhideb, Ghoshdastider, Umesh, Efthymiou, Vissarion, Kiehlmann, Elke, Sun, Wenfei, Dong, Hua, Ding, Lianggong, Amri, Ez-Zoubir, Nuutila, Pirjo, Virtanen, Kirsi A, Niemi, Tarja, Ukropcova, Barbara, Ukropec, Jozef, Pelczar, Pawel, Lamla, Thorsten, Hamilton, Bradford, Neubauer, Heike, Wolfrum, Christian
Published in Nature communications (08.12.2021)
Published in Nature communications (08.12.2021)
Get full text
Journal Article
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
Zimmermann, Tina, Thomas, Leo, Baader-Pagler, Tamara, Haebel, Peter, Simon, Eric, Reindl, Wolfgang, Bajrami, Besnik, Rist, Wolfgang, Uphues, Ingo, Drucker, Daniel J., Klein, Holger, Santhanam, Rakesh, Hamprecht, Dieter, Neubauer, Heike, Augustin, Robert
Published in Molecular metabolism (Germany) (01.12.2022)
Published in Molecular metabolism (Germany) (01.12.2022)
Get full text
Journal Article
Bmp4 Promotes a Brown to White-like Adipocyte Shift
Modica, Salvatore, Straub, Leon G., Balaz, Miroslav, Sun, Wenfei, Varga, Lukas, Stefanicka, Patrik, Profant, Milan, Simon, Eric, Neubauer, Heike, Ukropcova, Barbara, Ukropec, Jozef, Wolfrum, Christian
Published in Cell reports (Cambridge) (23.08.2016)
Published in Cell reports (Cambridge) (23.08.2016)
Get full text
Journal Article
Mutations and variants of ONECUT1 in diabetes
Philippi, Anne, Heller, Sandra, Costa, Ivan G, Senée, Valérie, Breunig, Markus, Li, Zhijian, Kwon, Gino, Russell, Ronan, Illing, Anett, Lin, Qiong, Hohwieler, Meike, Degavre, Anne, Zalloua, Pierre, Liebau, Stefan, Schuster, Michael, Krumm, Johannes, Zhang, Xi, Geusz, Ryan, Benthuysen, Jacqueline R, Wang, Allen, Chiou, Joshua, Gaulton, Kyle, Neubauer, Heike, Simon, Eric, Klein, Thomas, Wagner, Martin, Nair, Gopika, Besse, Céline, Dandine-Roulland, Claire, Olaso, Robert, Deleuze, Jean-François, Kuster, Bernhard, Hebrok, Matthias, Seufferlein, Thomas, Sander, Maike, Boehm, Bernhard O, Oswald, Franz, Nicolino, Marc, Julier, Cécile, Kleger, Alexander
Published in Nature medicine (01.11.2021)
Published in Nature medicine (01.11.2021)
Get full text
Journal Article
Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice
Efthymiou, Vissarion, Ding, Lianggong, Balaz, Miroslav, Sun, Wenfei, Balazova, Lucia, Straub, Leon G, Dong, Hua, Simon, Eric, Ghosh, Adhideb, Perdikari, Aliki, Keller, Svenja, Ghoshdastider, Umesh, Horvath, Carla, Moser, Caroline, Hamilton, Bradford, Neubauer, Heike, Wolfrum, Christian
Published in Nature communications (13.07.2023)
Published in Nature communications (13.07.2023)
Get full text
Journal Article
BATLAS: Deconvoluting Brown Adipose Tissue
Perdikari, Aliki, Leparc, Germán Gastón, Balaz, Miroslav, Pires, Nuno D., Lidell, Martin E., Sun, Wenfei, Fernandez-Albert, Francesc, Müller, Sebastian, Akchiche, Nassila, Dong, Hua, Balazova, Lucia, Opitz, Lennart, Röder, Eva, Klein, Holger, Stefanicka, Patrik, Varga, Lukas, Nuutila, Pirjo, Virtanen, Kirsi A., Niemi, Tarja, Taittonen, Markku, Rudofsky, Gottfried, Ukropec, Jozef, Enerbäck, Sven, Stupka, Elia, Neubauer, Heike, Wolfrum, Christian
Published in Cell reports (Cambridge) (16.10.2018)
Published in Cell reports (Cambridge) (16.10.2018)
Get full text
Journal Article
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application
Löffler, Mona C., Betz, Matthias J., Blondin, Denis P., Augustin, Robert, Sharma, Anand K., Tseng, Yu-Hua, Scheele, Camilla, Zimdahl, Heike, Mark, Michael, Hennige, Anita M., Wolfrum, Christian, Langhans, Wolfgang, Hamilton, Bradford S., Neubauer, Heike
Published in Molecular metabolism (Germany) (01.09.2021)
Published in Molecular metabolism (Germany) (01.09.2021)
Get full text
Journal Article
Roux-en-Y gastric bypass surgery reprograms enterocyte triglyceride metabolism and postprandial secretion in rats
Kaufman, Sharon, Arnold, Myrtha, Diaz, Abdiel Alvarado, Neubauer, Heike, Wolfrum, Susanne, Köfeler, Harald, Langhans, Wolfgang, Krieger, Jean-Philippe
Published in Molecular metabolism (Germany) (01.05.2019)
Published in Molecular metabolism (Germany) (01.05.2019)
Get full text
Journal Article
Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells
Markert, Elke K, Klein, Holger, Viollet, Coralie, Rust, Werner, Strobel, Benjamin, Kauschke, Stefan G, Makovoz, Bar, Neubauer, Heike, Bakker, Remko A, Blenkinsop, Timothy A
Published in Frontiers in cell and developmental biology (26.08.2022)
Published in Frontiers in cell and developmental biology (26.08.2022)
Get full text
Journal Article
Gene delivery to adipose tissue using transcriptionally targeted rAAV8 vectors
Uhrig-Schmidt, Silke, Geiger, Matthias, Luippold, Gerd, Birk, Gerald, Mennerich, Detlev, Neubauer, Heike, Grimm, Dirk, Wolfrum, Christian, Kreuz, Sebastian
Published in PloS one (31.12.2014)
Published in PloS one (31.12.2014)
Get full text
Journal Article
Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy
Lebon, Cecile, Neubauer, Heike, Berdugo, Marianne, Delaunay, Kimberley, Markert, Elke, Becker, Kolja, Baum-Kroker, Katja S., Prestle, Jürgen, Fuchs, Holger, Bakker, Remko A., Behar-Cohen, Francine
Published in Pharmaceutics (21.07.2021)
Published in Pharmaceutics (21.07.2021)
Get full text
Journal Article
An optimized protocol for isolation of hepatic leukocytes retrieved from murine and NASH liver biopsies
Bahrami, Ehsan, Geiger, Tobias, Steixner-Kumar, Agnes A., Santacruz, Diana, Viollet, Coralie, Dick, Alec, Roth, Yvonne, Schlingeloff, Patrycja, Schmidberger, Julian, Haenle, Mark, Kratzer, Wolfgang, Kitt, Kerstin, Neubauer, Heike, Simon, Eric, Krenkel, Oliver, Werner, Markus
Published in STAR protocols (15.12.2023)
Published in STAR protocols (15.12.2023)
Get full text
Journal Article
A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state
Schnapp, Gisela, Neubauer, Heike, Büttner, Frank H, Handschuh, Sandra, Lingard, Iain, Heilker, Ralf, Klinder, Klaus, Prestle, Jürgen, Walter, Rainer, Wolff, Michael, Zeeb, Markus, Debaene, Francois, Nar, Herbert, Fiegen, Dennis
Published in Communications chemistry (10.06.2020)
Published in Communications chemistry (10.06.2020)
Get full text
Journal Article
EGFL6 is increasingly expressed in human obesity and promotes proliferation of adipose tissue-derived stromal vascular cells
Oberauer, Rupert, Rist, Wolfgang, Lenter, Martin C, Hamilton, Bradford S, Neubauer, Heike
Published in Molecular and cellular biochemistry (01.10.2010)
Published in Molecular and cellular biochemistry (01.10.2010)
Get full text
Journal Article
TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling
Beaton, Nigel, Rudigier, Carla, Moest, Hansjörg, Müller, Sebastian, Mrosek, Nadja, Röder, Eva, Rudofsky, Gottfried, Rülicke, Thomas, Ukropec, Jozef, Ukropcova, Barbara, Augustin, Robert, Neubauer, Heike, Wolfrum, Christian
Published in Molecular metabolism (Germany) (01.11.2015)
Published in Molecular metabolism (Germany) (01.11.2015)
Get full text
Journal Article
Transcript Profiling Suggests That Differential Metabolic Adaptation of Mice to a High Fat Diet Is Associated with Changes in Liver to Muscle Lipid Fluxes
de Fourmestraux, Valérie, Neubauer, Heike, Poussin, Carine, Farmer, Pierre, Falquet, Laurent, Burcelin, Rémy, Delorenzi, Mauro, Thorens, Bernard
Published in The Journal of biological chemistry (03.12.2004)
Published in The Journal of biological chemistry (03.12.2004)
Get full text
Journal Article
The dual GCGR/GLP‐1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selection
Thomas, Leo, Martel, Eric, Rist, Wolfgang, Uphues, Ingo, Hamprecht, Dieter, Neubauer, Heike, Augustin, Robert
Published in Diabetes, obesity & metabolism (01.06.2024)
Published in Diabetes, obesity & metabolism (01.06.2024)
Get full text
Journal Article
749-P: Selection of BI 456906 as a Dual GCGR/GLP-1R Agonist Based on In Vitro Potency and In Vivo Target Engagement Biomarkers
AUGUSTIN, ROBERT, THOMAS, LEO, ZIMMERMANN, TINA, SIMON, ERIC, RIST, WOLFGANG, UPHUES, INGO, REINDL, WOLFGANG, KLEIN, THOMAS, NEUBAUER, HEIKE
Published in Diabetes (New York, N.Y.) (20.06.2023)
Published in Diabetes (New York, N.Y.) (20.06.2023)
Get full text
Journal Article
723-P: The Dual Glucagon and Glucagon-Like Peptide-1 Receptor (GCGR/GLP-1R) Agonist BI 4569Reduces Body Weight in Diet-Induced Obese Mice Based on Food Intake Reduction and an Increase in Energy Expenditure
ZIMMERMANN, TINA, THOMAS, LEO, BAADER-PAGLER, TAMARA, HAEBEL, PETER, NEUBAUER, HEIKE, SIMON, ERIC, REINDL, WOLFGANG, BAJRAMI, BESNIK, RIST, WOLFGANG, UPHUES, INGO, AUGUSTIN, ROBERT
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
Get full text
Journal Article
A high-throughput, image-based screen to identify kinases involved in brown adipocyte development
Perdikari, Aliki, Kulenkampff, Elisabeth, Rudigier, Carla, Neubauer, Heike, Luippold, Gerd, Redemann, Norbert, Wolfrum, Christian
Published in Science signaling (14.02.2017)
Published in Science signaling (14.02.2017)
Get more information
Journal Article