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BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Ozer, Hatice Gulcin, El-Gamal, Dalia, Powell, Ben, Hing, Zachary A, Blachly, James S, Harrington, Bonnie, Mitchell, Shaneice, Grieselhuber, Nicole R, Williams, Katie, Lai, Tzung-Huei, Alinari, Lapo, Baiocchi, Robert A, Brinton, Lindsey, Baskin, Elizabeth, Cannon, Matthew, Beaver, Larry, Goettl, Virginia M, Lucas, David M, Woyach, Jennifer A, Sampath, Deepa, Lehman, Amy M, Yu, Lianbo, Zhang, Jiazhong, Ma, Yan, Zhang, Ying, Spevak, Wayne, Shi, Songyuan, Severson, Paul, Shellooe, Rafe, Carias, Heidi, Tsang, Garson, Dong, Ken, Ewing, Todd, Marimuthu, Adhirai, Tantoy, Christina, Walters, Jason, Sanftner, Laura, Rezaei, Hamid, Nespi, Marika, Matusow, Bernice, Habets, Gaston, Ibrahim, Prabha, Zhang, Chao, Mathé, Ewy A, Bollag, Gideon, Byrd, John C, Lapalombella, Rosa
Published in Cancer discovery (01.04.2018)
Published in Cancer discovery (01.04.2018)
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Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor
Zhang, Chao, Ibrahim, Prabha N., Zhang, Jiazhong, Burton, Elizabeth A., Habets, Gaston, Zhang, Ying, Powell, Ben, West, Brian L., Matusow, Bernice, Tsang, Garson, Shellooe, Rafe, Carias, Heidi, Nguyen, Hoa, Marimuthu, Adhirai, Zhang, Kam Y. J., Oh, Angela, Bremer, Ryan, Hurt, Clarence R., Artis, Dean R., Wu, Guoxian, Nespi, Marika, Spevak, Wayne, Lin, Paul, Nolop, Keith, Hirth, Peter, Tesch, Greg H., Bollag, Gideon
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
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RAF inhibitors that evade paradoxical MAPK pathway activation
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Published in Nature (London) (22.10.2015)
Published in Nature (London) (22.10.2015)
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Overcoming Preclinical Safety Obstacles to Discover (S)‑N‑((1,2,3,5,6,7-Hexahydro‑s‑indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro‑5H‑pyrazolo[5,1‑b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.
Published in Journal of medicinal chemistry (10.11.2022)
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Optimization of Spray-Drying Parameters for Formulation Development at Preclinical Scale
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Published in AAPS PharmSciTech (20.12.2021)
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Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.
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Total synthesis of both enantiomers of trans-2,3- cis-3,4-dihydroxyproline
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Published in Tetrahedron: asymmetry (01.04.1996)
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Zeng, Mingshuo, Grandner, Jessica M., Bryan, Marian C., Verma, Vishal, Larouche-Gauthier, Robin, Leclerc, Jean-Philippe, Zhao, Liang, Haghshenas, Pouyan, Aubert-Nicol, Samuel, Yadav, Arun, Ashley, Melissa, Chen, Jacob Z., Durk, Matthew, Samy, Karen E., Nespi, Marika, Levy, Elizabeth, Merrick, Karl, Moffat, John G., Murray, Jeremy, Oh, Angela, Orr, Christine, Segal, Ehud, Sims, Jessica, Sneeringer, Christopher, Prangley, Madeleine, Vartanian, Steffan, Magnuson, Steven, Parr, Brendan T.
Published in ACS medicinal chemistry letters (14.09.2023)
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PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors
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Published in Clinical and experimental medicine (01.05.2019)
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EWING TODD, BOLLAG GIDEON, ZHANG YING, SPEVAK WAYNE, ZHANG JIAZHONG, WU GUOXIAN, NESPI MARIKA, CHO HANNA, SHI SONGYUAN, IBRAHIM PRABHA N, ZHANG CHAO, LIN JACK
Year of Publication 17.01.2018
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COMPOUNDS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
BURTON ELIZABETH A, NESPI MARIKA, SPEVAK WAYNE, SHI SONGYUAN, IBRAHIM PRABHA N, ZHANG CHAO, HIRTH KLAUS PETER, HABETS GASTON G
Year of Publication 03.02.2016
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Year of Publication 03.02.2016
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Abstract A229: BRAF inhibitors upregulate EGFR ligands: A molecular link to RAF inhibitor-induced cutaneous squamous cell carcinomas
Ma, Yan, Zhang, Chao, Habets, Gaston, Burton, Elizabeth A., Wong, Bernice, Nguyen, Hoa, Spevak, Wayne, zhang, Jiazhong, Cho, Hanna, Wu, Guoxian, Lin, Jack L., Ewing, Todd, Zhang, Ying, Shi, Songyuan, Nespi, Marika, Tsang, Garson, Marimuthu, Adhirai, Light, Emily, Powell, Ben, Shellooe, Rafe, Tsai, James, West, Brian L., Ibrahim, Prabha N., Hirth, Peter, Bollag, Gideon
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
EWING TODD, CHAN KATRINA, ZHANG YING, WU GUOXIAN, NESPI MARIKA, SPEVAK WAYNE, IBRAHIM PRABHA N, LIN JACK
Year of Publication 25.08.2015
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Year of Publication 25.08.2015
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COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
EWING TODD, ZHANG YING, SPEVAK WAYNE, ZHANG JIAZHONG, WU GUOXIAN, NESPI MARIKA, CHO HANNA, SHI SONGYUAN, IBRAHIM PRABHA N, ZHANG CHAO, LIN JACK
Year of Publication 28.05.2014
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Year of Publication 28.05.2014
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