Oncogenic protein interfaces: small molecules, big challenges
Nero, Tracy L, Morton, Craig J, Holien, Jessica K, Wielens, Jerome, Parker, Michael W
Published in Nature reviews. Cancer (01.04.2014)
Published in Nature reviews. Cancer (01.04.2014)
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The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling
Broughton, Sophie E., Dhagat, Urmi, Hercus, Timothy R., Nero, Tracy L., Grimbaldeston, Michele A., Bonder, Claudine S., Lopez, Angel F., Parker, Michael W.
Published in Immunological reviews (01.11.2012)
Published in Immunological reviews (01.11.2012)
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Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
Braig, David, Nero, Tracy L, Koch, Hans-Georg, Kaiser, Benedict, Wang, Xiaowei, Thiele, Jan R, Morton, Craig J, Zeller, Johannes, Kiefer, Jurij, Potempa, Lawrence A, Mellett, Natalie A, Miles, Luke A, Du, Xiao-Jun, Meikle, Peter J, Huber-Lang, Markus, Stark, G Björn, Parker, Michael W, Peter, Karlheinz, Eisenhardt, Steffen U
Published in Nature communications (23.01.2017)
Published in Nature communications (23.01.2017)
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Journal Article
C-reactive protein, immunothrombosis and venous thromboembolism
Dix, Caroline, Zeller, Johannes, Stevens, Hannah, Eisenhardt, Steffen U., Shing, Karen S. Cheung Tung, Nero, Tracy L., Morton, Craig J., Parker, Michael W., Peter, Karlheinz, McFadyen, James D.
Published in Frontiers in immunology (13.09.2022)
Published in Frontiers in immunology (13.09.2022)
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Journal Article
Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling
Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Dottore, Mara, McClure, Barbara J., Dhagat, Urmi, Taing, Houng, Gorman, Michael A., King-Scott, Jack, Lopez, Angel F., Parker, Michael W.
Published in Structure (London) (02.08.2016)
Published in Structure (London) (02.08.2016)
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Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators
Flierl, Ulrike, Nero, Tracy L, Lim, Bock, Arthur, Jane F, Yao, Yu, Jung, Stephanie M, Gitz, Eelo, Pollitt, Alice Y, Zaldivia, Maria T K, Jandrot-Perrus, Martine, Schäfer, Andreas, Nieswandt, Bernhard, Andrews, Robert K, Parker, Michael W, Gardiner, Elizabeth E, Peter, Karlheinz
Published in The Journal of experimental medicine (09.02.2015)
Published in The Journal of experimental medicine (09.02.2015)
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Journal Article
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein
Zeller, Johannes, Cheung Tung Shing, Karen S, Nero, Tracy L, McFadyen, James D, Krippner, Guy, Bogner, Balázs, Kreuzaler, Sheena, Kiefer, Jurij, Horner, Verena K, Braig, David, Danish, Habiba, Baratchi, Sara, Fricke, Mark, Wang, Xiaowei, Kather, Michel G, Kammerer, Bernd, Woollard, Kevin J, Sharma, Prerna, Morton, Craig J, Pietersz, Geoffrey, Parker, Michael W, Peter, Karlheinz, Eisenhardt, Steffen U
Published in EMBO molecular medicine (11.01.2023)
Published in EMBO molecular medicine (11.01.2023)
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Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth
Thilakasiri, Pathum, Huynh, Jennifer, Poh, Ashleigh R, Tan, Chin Wee, Nero, Tracy L, Tran, Kelly, Parslow, Adam C, Afshar‐Sterle, Shoukat, Baloyan, David, Hannan, Natalie J, Buchert, Michael, Scott, Andrew Mark, Griffin, Michael DW, Hollande, Frederic, Parker, Michael W, Putoczki, Tracy L, Ernst, Matthias, Chand, Ashwini L
Published in EMBO molecular medicine (01.04.2019)
Published in EMBO molecular medicine (01.04.2019)
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Journal Article
A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
Broughton, Sophie E, Hercus, Timothy R, Nero, Tracy L, Kan, Winnie L, Barry, Emma F, Dottore, Mara, Cheung Tung Shing, Karen S, Morton, Craig J, Dhagat, Urmi, Hardy, Matthew P, Wilson, Nicholas J, Downton, Matthew T, Schieber, Christine, Hughes, Timothy P, Lopez, Angel F, Parker, Michael W
Published in Nature communications (26.01.2018)
Published in Nature communications (26.01.2018)
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Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer
Dmello, Rhynelle S, Palmieri, Michelle, Thilakasiri, Pathum S, Doughty, Larissa, Nero, Tracy L, Poh, Ashleigh R, To, Sarah Q, Lee, Erinna F, Douglas Fairlie, W, Mielke, Lisa, Parker, Michael W, Poon, Ivan K H, Batlle, Eduard, Ernst, Matthias, Chand, Ashwini L
Published in Cell death & disease (10.04.2024)
Published in Cell death & disease (10.04.2024)
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Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.
Published in iScience (27.09.2019)
Published in iScience (27.09.2019)
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Journal Article
Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody
Broughton, Sophie E., Hercus, Timothy R., Hardy, Matthew P., McClure, Barbara J., Nero, Tracy L., Dottore, Mara, Huynh, Huy, Braley, Hal, Barry, Emma F., Kan, Winnie L., Dhagat, Urmi, Scotney, Pierre, Hartman, Dallas, Busfield, Samantha J., Owczarek, Catherine M., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.
Published in Cell reports (Cambridge) (24.07.2014)
Published in Cell reports (Cambridge) (24.07.2014)
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Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
Thomas, Daniel, Powell, Jason A., Vergez, Francois, Segal, David H., Nguyen, Nhu-Y.N., Baker, Adele, Teh, Tse-Chieh, Barry, Emma F., Sarry, Jean-Emmanuel, Lee, Erwin M., Nero, Tracy L., Jabbour, Anissa M., Pomilio, Giovanna, Green, Benjamin D., Manenti, Stéphane, Glaser, Stefan P., Parker, Michael W., Lopez, Angel F., Ekert, Paul G., Lock, Richard B., Huang, David C.S., Nilsson, Susie K., Récher, Christian, Wei, Andrew H., Guthridge, Mark A.
Published in Blood (01.08.2013)
Published in Blood (01.08.2013)
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Journal Article
Characterization of pathogenic human monoclonal autoantibodies against GM-CSF
Wang, Yanni, Thomson, Christy A., Allan, Lenka L., Jackson, Linda M., Olson, Melanie, Hercus, Timothy R., Nero, Tracy L., Turner, Amanda, Parker, Michael W., Lopez, Angel L., Waddell, Thomas K., Anderson, Gary P., Hamilton, John A., Schrader, John W.
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
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Journal Article
Small molecule proprotein convertase inhibitors for inhibition of embryo implantation
Ho, Huiting, Singh, Harmeet, Heng, Sophea, Nero, Tracy L, Paule, Sarah, Parker, Michael W, Johnson, Alan T, Jiao, Guan-Sheng, Nie, Guiying
Published in PloS one (04.12.2013)
Published in PloS one (04.12.2013)
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Journal Article
Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments
Perini, Marcos V., Dmello, Rhynelle S., Nero, Tracy L., Chand, Ashwini L.
Published in Pharmacology & therapeutics (Oxford) (01.07.2020)
Published in Pharmacology & therapeutics (Oxford) (01.07.2020)
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Repurposing of drugs as STAT3 inhibitors for cancer therapy
Thilakasiri, Pathum S., Dmello, Rhynelle S., Nero, Tracy L., Parker, Michael W., Ernst, Matthias, Chand, Ashwini L.
Published in Seminars in cancer biology (01.01.2021)
Published in Seminars in cancer biology (01.01.2021)
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Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
Morrow, Marisa R, Batchuluun, Battsetseg, Wu, Jianhan, Ahmadi, Elham, Leroux, Julie M, Mohammadi-Shemirani, Pedrum, Desjardins, Eric M, Wang, Zhichao, Tsakiridis, Evangelia E, Lavoie, Declan C T, Reihani, Amir, Smith, Brennan K, Kwiecien, Jacek M, Lally, James S V, Nero, Tracy L, Parker, Michael W, Ask, Kjetil, Scott, John W, Jiang, Lei, Paré, Guillaume, Pinkosky, Stephen L, Steinberg, Gregory R
Published in Cell metabolism (07.06.2022)
Published in Cell metabolism (07.06.2022)
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Protein structure and computational drug discovery
Nero, Tracy L, Parker, Michael W, Morton, Craig J
Published in Biochemical Society transactions (19.10.2018)
Published in Biochemical Society transactions (19.10.2018)
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