Protein structure and computational drug discovery
Nero, Tracy L, Parker, Michael W, Morton, Craig J
Published in Biochemical Society transactions (19.10.2018)
Published in Biochemical Society transactions (19.10.2018)
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Journal Article
Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions
Ishii, Kenta, Hermans, Stefan J, Georgopoulou, Maria Eleni, Nero, Tracy L, Hancock, Nancy C, Crespi, Gabriela A N, Gorman, Michael A, Gooi, Jonathan H, Parker, Michael W
Published in The FEBS journal (26.09.2024)
Published in The FEBS journal (26.09.2024)
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Journal Article
The βc receptor family – Structural insights and their functional implications
Broughton, Sophie E., Nero, Tracy L., Dhagat, Urmi, Kan, Winnie L., Hercus, Timothy R., Tvorogov, Denis, Lopez, Angel F., Parker, Michael W.
Published in Cytokine (Philadelphia, Pa.) (01.08.2015)
Published in Cytokine (Philadelphia, Pa.) (01.08.2015)
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Journal Article
Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation
Zeller, Johannes, Loseff-Silver, Julia, Khoshmanesh, Khashayar, Baratchi, Sara, Lai, Austin, Nero, Tracy L, Roy, Abhishek, Watson, Anna, Dayawansa, Nalin, Sharma, Prerna, Barbaro-Wahl, Anastasia, Chen, Yung Chih, Moon, Mitchell, Vidallon, Mark Louis P, Huang, Angela, Thome, Julia, Cheung Tung Shing, Karen S, Harvie, Dalton, Bongiovanni, Marie N, Braig, David, Morton, Craig J, Htun, Nay M, Stub, Dion, Walton, Anthony, Horowitz, John, Wang, Xiaowei, Pietersz, Geoffrey, Parker, Michael W, Eisenhardt, Steffen U, McFadyen, James D, Peter, Karlheinz
Published in Circulation research (18.10.2024)
Published in Circulation research (18.10.2024)
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Journal Article
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms
Pinkosky, Stephen L, Scott, John W, Desjardins, Eric M, Smith, Brennan K, Day, Emily A, Ford, Rebecca J, Langendorf, Christopher G, Ling, Naomi X Y, Nero, Tracy L, Loh, Kim, Galic, Sandra, Hoque, Ashfaqul, Smiles, William J, Ngoei, Kevin R W, Parker, Michael W, Yan, Yan, Melcher, Karsten, Kemp, Bruce E, Oakhill, Jonathan S, Steinberg, Gregory R
Published in Nature metabolism (01.09.2020)
Published in Nature metabolism (01.09.2020)
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Journal Article
A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites
Sernee, M. Fleur, Ralton, Julie E., Nero, Tracy L., Sobala, Lukasz F., Kloehn, Joachim, Vieira-Lara, Marcel A., Cobbold, Simon A., Stanton, Lauren, Pires, Douglas E.V., Hanssen, Eric, Males, Alexandra, Ward, Tom, Bastidas, Laurence M., van der Peet, Phillip L., Parker, Michael W., Ascher, David B., Williams, Spencer J., Davies, Gideon J., McConville, Malcolm J.
Published in Cell host & microbe (11.09.2019)
Published in Cell host & microbe (11.09.2019)
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Journal Article
Signalling by the βc family of cytokines
Hercus, Timothy R, Dhagat, Urmi, Kan, Winnie L.T, Broughton, Sophie E, Nero, Tracy L, Perugini, Michelle, Sandow, Jarrod J, D’Andrea, Richard J, Ekert, Paul G, Hughes, Timothy, Parker, Michael W, Lopez, Angel F
Published in Cytokine & growth factor reviews (01.06.2013)
Published in Cytokine & growth factor reviews (01.06.2013)
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Journal Article
Messing with βc: A unique receptor with many goals
Kan, Winnie L., Cheung Tung Shing, Karen S., Nero, Tracy L., Hercus, Timothy R., Tvorogov, Denis, Parker, Michael W., Lopez, Angel F.
Published in Seminars in immunology (01.04.2021)
Published in Seminars in immunology (01.04.2021)
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Journal Article
Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
Kan, Winnie L, Dhagat, Urmi, Kaufmann, Kerstin B, Hercus, Timothy R, Nero, Tracy L, Zeng, Andy G X, Toubia, John, Barry, Emma F, Broughton, Sophie E, Gomez, Guillermo A, Benard, Brooks A, Dottore, Mara, Cheung Tung Shing, Karen S, Boutzen, Héléna, Samaraweera, Saumya E, Simpson, Kaylene J, Jin, Liqing, Goodall, Gregory J, Begley, C Glenn, Thomas, Daniel, Ekert, Paul G, Tvorogov, Denis, D'Andrea, Richard J, Dick, John E, Parker, Michael W, Lopez, Angel F
Published in Cancer discovery (04.08.2023)
Published in Cancer discovery (04.08.2023)
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Journal Article
EPO does not promote interaction between the erythropoietin and beta-common receptors
Cheung Tung Shing, Karen S., Broughton, Sophie E., Nero, Tracy L., Gillinder, Kevin, Ilsley, Melissa D., Ramshaw, Hayley, Lopez, Angel F., Griffin, Michael D. W., Parker, Michael W., Perkins, Andrew C., Dhagat, Urmi
Published in Scientific reports (20.08.2018)
Published in Scientific reports (20.08.2018)
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Journal Article
Role of the β Common (βc) Family of Cytokines in Health and Disease
Hercus, Timothy R, Kan, Winnie L T, Broughton, Sophie E, Tvorogov, Denis, Ramshaw, Hayley S, Sandow, Jarrod J, Nero, Tracy L, Dhagat, Urmi, Thompson, Emma J, Shing, Karen S Cheung Tung, McKenzie, Duncan R, Wilson, Nicholas J, Owczarek, Catherine M, Vairo, Gino, Nash, Andrew D, Tergaonkar, Vinay, Hughes, Timothy, Ekert, Paul G, Samuel, Michael S, Bonder, Claudine S, Grimbaldeston, Michele A, Parker, Michael W, Lopez, Angel F
Published in Cold Spring Harbor perspectives in biology (01.06.2018)
Published in Cold Spring Harbor perspectives in biology (01.06.2018)
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Journal Article
Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma
Seneviratne, Janith A., Ravindrarajah, Daenikka, Carter, Daniel R., Zhai, Vicki, Lalwani, Amit, Krishan, Sukriti, Balachandran, Anushree, Ng, Ernest, Pandher, Ruby, Wong, Matthew, Nero, Tracy L., Wang, Shudong, Norris, Murray D., Haber, Michelle, Liu, Tao, Parker, Michael W., Cheung, Belamy B., Marshall, Glenn M.
Published in Cancer medicine (Malden, MA) (01.11.2024)
Published in Cancer medicine (Malden, MA) (01.11.2024)
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Journal Article
Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9
Phillipson, Louisa J., Segal, David H., Nero, Tracy L., Parker, Michael W., Wan, Soo San, de Silva, Melanie, Guthridge, Mark A., Wei, Andrew H., Burns, Christopher J.
Published in Bioorganic & medicinal chemistry (01.10.2015)
Published in Bioorganic & medicinal chemistry (01.10.2015)
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Journal Article
Structural biology of cell surface receptors implicated in Alzheimer’s disease
Hermans, Stefan J., Nero, Tracy L., Morton, Craig J., Gooi, Jonathan H., Crespi, Gabriela A. N., Hancock, Nancy C., Gao, Chen, Ishii, Kenta, Markulić, Jasmina, Parker, Michael W.
Published in Biophysical reviews (01.02.2022)
Published in Biophysical reviews (01.02.2022)
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Journal Article
Author Correction: EPO does not promote interaction between the erythropoietin and beta-common receptors
Cheung Tung Shing, Karen S., Broughton, Sophie E., Nero, Tracy L., Gillinder, Kevin, Ilsley, Melissa D., Ramshaw, Hayley, Lopez, Angel F., Griffin, Michael D. W., Parker, Michael W., Perkins, Andrew C., Dhagat, Urmi
Published in Scientific reports (21.05.2019)
Published in Scientific reports (21.05.2019)
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Journal Article
The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities
Dhagat, Urmi, Hercus, Timothy R, Broughton, Sophie E, Nero, Tracy L, Cheung Tung Shing, Karen S, Barry, Emma F, Thomson, Christy A, Bryson, Steve, Pai, Emil F, McClure, Barbara J, Schrader, John W, Lopez, Angel F, Parker, Michael W
Published in mAbs (01.10.2018)
Published in mAbs (01.10.2018)
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Journal Article
PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: In vitro bioactivity, stability and in vivo pharmacokinetics
Ho, Huiting, Nero, Tracy L., Singh, Harmeet, Parker, Michael W., Nie, Guiying
Published in Peptides (New York, N.Y. : 1980) (01.12.2012)
Published in Peptides (New York, N.Y. : 1980) (01.12.2012)
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Journal Article
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)
Burns, Christopher J., Bourke, David G., Andrau, Laura, Bu, Xianyong, Charman, Susan A., Donohue, Andrew C., Fantino, Emmanuelle, Farrugia, Michelle, Feutrill, John T., Joffe, Max, Kling, Marcel R., Kurek, Margarita, Nero, Tracy L., Nguyen, Thao, Palmer, James T., Phillips, Ian, Shackleford, David M., Sikanyika, Harrison, Styles, Michelle, Su, Stephen, Treutlein, Herbert, Zeng, Jun, Wilks, Andrew F.
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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Journal Article
Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362
Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Dhagat, Urmi, Owczarek, Catherine M., Hardy, Matthew P., Fabri, Louis J., Scotney, Pierre D., Nash, Andrew D., Wilson, Nicholas J., Lopez, Angel F., Parker, Michael W.
Published in Acta crystallographica. Section F, Structural biology communications (01.03.2014)
Published in Acta crystallographica. Section F, Structural biology communications (01.03.2014)
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