CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease
Kacher, Radhia, Lamazière, Antonin, Heck, Nicolas, Kappes, Vincent, Mounier, Coline, Despres, Gaëtan, Dembitskaya, Yulia, Perrin, Elodie, Christaller, Wilhelm, Sasidharan Nair, Satish, Messent, Valérie, Cartier, Nathalie, Vanhoutte, Peter, Venance, Laurent, Saudou, Frédéric, Néri, Christian, Caboche, Jocelyne, Betuing, Sandrine
Published in Brain (London, England : 1878) (01.08.2019)
Published in Brain (London, England : 1878) (01.08.2019)
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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Burnett, Camilla, Valentini, Sara, Cabreiro, Filipe, Goss, Martin, Somogyvári, Milán, Piper, Matthew D., Hoddinott, Matthew, Sutphin, George L., Leko, Vid, McElwee, Joshua J., Vazquez-Manrique, Rafael P., Orfila, Anne-Marie, Ackerman, Daniel, Au, Catherine, Vinti, Giovanna, Riesen, Michèle, Howard, Ken, Neri, Christian, Bedalov, Antonio, Kaeberlein, Matt, Sőti, Csaba, Partridge, Linda, Gems, David
Published in Nature (London) (22.09.2011)
Published in Nature (London) (22.09.2011)
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AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease
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Published in Human molecular genetics (15.03.2016)
Published in Human molecular genetics (15.03.2016)
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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
Luthi-Carter, Ruth, Taylor, David M, Pallos, Judit, Lambert, Emmanuel, Amore, Allison, Parker, Alex, Moffitt, Hilary, Smith, Donna L, Runne, Heike, Gokce, Ozgun, Kuhn, Alexandre, Xiang, Zhongmin, Maxwell, Michele M, Reeves, Steven A, Bates, Gillian P, Neri, Christian, Thompson, Leslie M, Marsh, J. Lawrence, Kazantsev, Aleksey G
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2010)
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Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
van der Goot, Annemieke T, Zhu, Wentao, Vázquez-Manrique, Rafael P, Seinstra, Renée I, Dettmer, Katja, Michels, Helen, Farina, Francesca, Krijnen, Jasper, Melki, Ronald, Buijsman, Rogier C, Ruiz Silva, Mariana, Thijssen, Karen L, Kema, Ido P, Neri, Christian, Oefner, Peter J, Nollen, Ellen A. A
Published in Proceedings of the National Academy of Sciences - PNAS (11.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (11.09.2012)
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Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures
Merienne, Nicolas, Meunier, Cécile, Schneider, Anne, Seguin, Jonathan, Nair, Satish S., Rocher, Anne B., Le Gras, Stéphanie, Keime, Céline, Faull, Richard, Pellerin, Luc, Chatton, Jean-Yves, Neri, Christian, Merienne, Karine, Déglon, Nicole
Published in Cell reports (Cambridge) (26.02.2019)
Published in Cell reports (Cambridge) (26.02.2019)
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The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease
Farina, Francesca, Lambert, Emmanuel, Commeau, Lucie, Lejeune, François-Xavier, Roudier, Nathalie, Fonte, Cosima, Parker, J. Alex, Boddaert, Jacques, Verny, Marc, Baulieu, Etienne-Emile, Neri, Christian
Published in Scientific reports (21.06.2017)
Published in Scientific reports (21.06.2017)
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Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin
Megret, Lucile, Gris, Barbara, Sasidharan Nair, Satish, Cevost, Jasmin, Wertz, Mary, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F, Wilkinson, Hilary, Heiman, Myriam, Neri, Christian
Published in eLife (23.02.2021)
Published in eLife (23.02.2021)
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The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity
Tourette, Cendrine, Farina, Francesca, Vazquez-Manrique, Rafael P, Orfila, Anne-Marie, Voisin, Jessica, Hernandez, Sonia, Offner, Nicolas, Parker, J Alex, Menet, Sophie, Kim, Jinho, Lyu, Jungmok, Choi, Si Ho, Cormier, Kerry, Edgerly, Christina K, Bordiuk, Olivia L, Smith, Karen, Louise, Anne, Halford, Michael, Stacker, Steven, Vert, Jean-Philippe, Ferrante, Robert J, Lu, Wange, Neri, Christian
Published in PLoS biology (01.06.2014)
Published in PLoS biology (01.06.2014)
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Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons
Lejeune, François-Xavier, Mesrob, Lilia, Parmentier, Frédéric, Bicep, Cedric, Vazquez-Manrique, Rafael P, Parker, J Alex, Vert, Jean-Philippe, Tourette, Cendrine, Neri, Christian
Published in BMC genomics (13.03.2012)
Published in BMC genomics (13.03.2012)
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RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement
Abu-Baker, Aida, Kharma, Nawwaf, Perreault, Jonathan, Grant, Alanna, Shekarabi, Masoud, Maios, Claudia, Dona, Michele, Neri, Christian, Dion, Patrick A., Parker, Alex, Varin, Luc, Rouleau, Guy A.
Published in Molecular therapy. Nucleic acids (15.04.2019)
Published in Molecular therapy. Nucleic acids (15.04.2019)
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Huntingtin-Interacting Protein 1 Influences Worm and Mouse Presynaptic Function and Protects Caenorhabditis elegans Neurons against Mutant Polyglutamine Toxicity
Parker, J. Alex, Metzler, Martina, Georgiou, John, Mage, Marilyne, Roder, John C, Rose, Ann M, Hayden, Michael R, Neri, Christian
Published in The Journal of neuroscience (10.10.2007)
Published in The Journal of neuroscience (10.10.2007)
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Expanded Polyglutamines in Caenorhabditis elegans Cause Axonal Abnormalities and Severe Dysfunction of PLM Mechanosensory Neurons without Cell Death
Parker, J. Alex, Connolly, John B., Wellington, Cheryll, Hayden, Michael, Dausset, Jean, Neri, Christian
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2001)
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