Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
Krafcikova, Petra, Silhan, Jan, Nencka, Radim, Boura, Evzen
Published in Nature communications (24.07.2020)
Published in Nature communications (24.07.2020)
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Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein
Dinesh, Dhurvas Chandrasekaran, Chalupska, Dominika, Silhan, Jan, Koutna, Eliska, Nencka, Radim, Veverka, Vaclav, Boura, Evzen
Published in PLoS pathogens (02.12.2020)
Published in PLoS pathogens (02.12.2020)
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Coronaviral RNA-methyltransferases: function, structure and inhibition
Nencka, Radim, Silhan, Jan, Klima, Martin, Otava, Tomas, Kocek, Hugo, Krafcikova, Petra, Boura, Evzen
Published in Nucleic acids research (25.01.2022)
Published in Nucleic acids research (25.01.2022)
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Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase
Silhan, Jan, Klima, Martin, Otava, Tomas, Skvara, Petr, Chalupska, Dominika, Chalupsky, Karel, Kozic, Jan, Nencka, Radim, Boura, Evzen
Published in Nature communications (20.04.2023)
Published in Nature communications (20.04.2023)
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High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses
Cihlova, Bara, Huskova, Andrea, Böserle, Jiri, Nencka, Radim, Boura, Evzen, Silhan, Jan
Published in Molecules (Basel, Switzerland) (22.06.2021)
Published in Molecules (Basel, Switzerland) (22.06.2021)
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Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein
Smola, Miroslav, Gutten, Ondrej, Dejmek, Milan, Kožíšek, Milan, Evangelidis, Thomas, Tehrani, Zahra Aliakbar, Novotná, Barbora, Nencka, Radim, Birkuš, Gabriel, Rulíšek, Lubomír, Boura, Evzen
Published in Angewandte Chemie International Edition (26.04.2021)
Published in Angewandte Chemie International Edition (26.04.2021)
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Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)
Pimková Polidarová, Markéta, Břehová, Petra, Kaiser, Martin Maxmilian, Smola, Miroslav, Dračínský, Martin, Smith, Joshua, Marek, Aleš, Dejmek, Milan, Šála, Michal, Gutten, Ondrej, Rulíšek, Lubomír, Novotná, Barbora, Brázdová, Andrea, Janeba, Zlatko, Nencka, Radim, Boura, Evzen, Páv, Ondřej, Birkuš, Gabriel
Published in Journal of medicinal chemistry (10.06.2021)
Published in Journal of medicinal chemistry (10.06.2021)
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Journal Article
Nucleoside inhibitors of tick-borne encephalitis virus
Eyer, Luděk, Valdés, James J, Gil, Victor A, Nencka, Radim, Hřebabecký, Hubert, Šála, Michal, Salát, Jiří, Černý, Jiří, Palus, Martin, De Clercq, Erik, Růžek, Daniel
Published in Antimicrobial agents and chemotherapy (01.09.2015)
Published in Antimicrobial agents and chemotherapy (01.09.2015)
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Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase
Hercík, Kamil, Kozak, Jaroslav, Šála, Michal, Dejmek, Milan, Hřebabecký, Hubert, Zborníková, Eva, Smola, Miroslav, Ruzek, Daniel, Nencka, Radim, Boura, Evzen
Published in Antiviral research (01.01.2017)
Published in Antiviral research (01.01.2017)
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Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
Dejmek, Milan, Konkoľová, Eva, Eyer, Luděk, Straková, Petra, Svoboda, Pavel, Šála, Michal, Krejčová, Kateřina, Růžek, Daniel, Boura, Evzen, Nencka, Radim
Published in Viruses (11.08.2021)
Published in Viruses (11.08.2021)
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Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein
Klima, Martin, Tóth, Dániel J., Hexnerova, Rozalie, Baumlova, Adriana, Chalupska, Dominika, Tykvart, Jan, Rezabkova, Lenka, Sengupta, Nivedita, Man, Petr, Dubankova, Anna, Humpolickova, Jana, Nencka, Radim, Veverka, Vaclav, Balla, Tamas, Boura, Evzen
Published in Scientific reports (24.03.2016)
Published in Scientific reports (24.03.2016)
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Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39
Zilecka, Eva, Klima, Martin, Stefek, Milan, Dejmek, Milan, Nencka, Radim, Boura, Evzen
Published in Journal of structural biology. X (01.12.2024)
Published in Journal of structural biology. X (01.12.2024)
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A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha[S]
Sengupta, Nivedita, Jović, Marko, Barnaeva, Elena, Kim, David W., Hu, Xin, Southall, Noel, Dejmek, Milan, Mejdrova, Ivana, Nencka, Radim, Baumlova, Adriana, Chalupska, Dominika, Boura, Evzen, Ferrer, Marc, Marugan, Juan, Balla, Tamas
Published in Journal of lipid research (01.03.2019)
Published in Journal of lipid research (01.03.2019)
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Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics
Tóth, Luca Julianna, Krejčová, Kateřina, Dejmek, Milan, Žilecká, Eva, Klepetářová, Blanka, Poštová Slavětínská, Lenka, Bouřa, Evžen, Nencka, Radim
Published in Beilstein journal of organic chemistry (06.05.2024)
Published in Beilstein journal of organic chemistry (06.05.2024)
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Antiviral Activity of 7‑Substituted 7‑Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses
Milisavljevic, Nemanja, Konkolová, Eva, Kozák, Jaroslav, Hodek, Jan, Veselovská, Lucia, Sýkorová, Veronika, Čížek, Karel, Pohl, Radek, Eyer, Luděk, Svoboda, Pavel, Růžek, Daniel, Weber, Jan, Nencka, Radim, Bouřa, Evžen, Hocek, Michal
Published in ACS infectious diseases (12.02.2021)
Published in ACS infectious diseases (12.02.2021)
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Benchmark Theoretical and Experimental Study on 15N NMR Shifts of Oxidatively Damaged Guanine
Dračínský, Martin, Šála, Michal, Klepetářová, Blanka, Šebera, Jakub, Fukal, Jiří, Holečková, Veronika, Tanaka, Yoshiyuki, Nencka, Radim, Sychrovský, Vladimír
Published in The journal of physical chemistry. B (11.02.2016)
Published in The journal of physical chemistry. B (11.02.2016)
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Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides
Hrebabecky, Hubert, Prochazkova, Eliska, Sala, Michal, Plackova, Pavla, Tloustova, Eva, Barauskas, Ona, Lee, Yu-Jen, Tian, Yang, Mackman, Richard, Nencka, Radim
Published in Organic & biomolecular chemistry (01.01.2015)
Published in Organic & biomolecular chemistry (01.01.2015)
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The activation of N-glycosidic bond cleavage performed by base-excision repair enzyme hOGG1; theoretical study of the role of Lys 249 residue in activation of G, OxoG and FapyG
Šebera, Jakub, Trantírek, Lukáš, Tanaka, Yoshiyuki, Nencka, Radim, Fukal, Jiří, Sychrovský, Vladimír
Published in RSC advances (2014)
Published in RSC advances (2014)
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