Contribution of analog signaling to neurotransmitter interactions and behavior: Role of transporter‐mediated nonquantal dopamine release
Román, Viktor, Kedves, Rita, Kelemen, Kristóf, Némethy, Zsolt, Sperlágh, Beáta, Lendvai, Balázs, Vizi, E. Sylvester
Published in Physiological reports (01.11.2021)
Published in Physiological reports (01.11.2021)
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Journal Article
Discovery of novel steroidal histamine H-3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives
Ledneczki, Istvan, Nemethy, Zsolt, Tapolcsanyi, Pal, Eles, Janos, Greiner, Istvan, Gabor, Eszter, Varga, Balazs, Balazs, Ottilia, Roman, Viktor, Levay, Gyorgy, Maho, Sandor
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Journal Article
Discovery of novel steroidal histamine H-3 receptor antagonists inverse agonists
Ledneczki, Istvan, Tapolcsanyi, Pal, Gabor, Eszter, Eles, Janos, Greiner, Istvan, Schmidt, Eva, Nemethy, Zsolt, Kedves, Rita Soukupne, Balaks, Ottilia, Roman, Viktor, Levay, Gyorgy, Maho, Sandor
Published in Bioorganic & medicinal chemistry letters (01.10.2017)
Published in Bioorganic & medicinal chemistry letters (01.10.2017)
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Journal Article
Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists
Ledneczki, István, Tapolcsányi, Pál, Gábor, Eszter, Éles, János, Barabás, Júlia, Béni, Zoltán, Varga, Balázs, Balázs, Ottilia, Román, Viktor, Fodor, László, Szikra, Judit, Vastag, Mónika, Lévay, György, Schmidt, Éva, Lendvai, Balázs, Greiner, István, Kiss, Béla, Némethy, Zsolt, Mahó, Sándor
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560)
Ledneczki, István, Némethy, Zsolt, Molnár, Katalin Dudásné, Tapolcsányi, Pál, Ilkei, Viktor, Vágó, István, Kolok, Sándor, Thán, Márta, Laszy, Judit, Balázs, Ottilia, Krámos, Balázs, Szigetvári, Áron, Bata, Imre, Makó, Attila, Visegrády, András, Fodor, László, Vastag, Mónika, Lévay, György, Lendvai, Balázs, Greiner, István, Éles, János
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Cariprazine (RGH-188), a Dopamine D 3 Receptor-Preferring, D 3 /D 2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile
Kiss, Béla, Horváth, Attila, Némethy, Zsolt, Schmidt, Éva, Laszlovszky, István, Bugovics, Gyula, Fazekas, Károly, Hornok, Katalin, Orosz, Szabolcs, Gyertyán, István, Ágai-Csongor, Éva, Domány, György, Tihanyi, Károly, Adham, Nika, Szombathelyi, Zsolt
Published in The Journal of pharmacology and experimental therapeutics (01.04.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2010)
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Cellular Mechanisms of Cognitive Enhancement: The In Vivo Modulation of the Firing Activity and the Responsiveness of Rat Hippocampal Neurons by Memantine and Alpha7 Nicotinic Acetylcholine Receptor Ligands
Nagy, Lili Veronika, Bali, Zsolt Kristóf, Ledneczki, István, Némethy, Zsolt, Lendvai, Balázs, Hernádi, István
Published in ASN neuro (2024)
Published in ASN neuro (2024)
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Journal Article
Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H 3 receptor antagonist/inverse agonist
Némethy, Zsolt, Kiss, Béla, Lethbridge, Natasha, Chazot, Paul, Hajnik, Tünde, Tóth, Attila, Détári, László, Schmidt, Éva, Czurkó, András, Kostyalik, Diána, Oláh, Vilmos, Hernádi, István, Balázs, Ottilia, Vizi, E Sylvester, Ledneczki, István, Mahó, Sándor, Román, Viktor, Lendvai, Balázs, Lévay, György
Published in European journal of pharmacology (05.02.2022)
Published in European journal of pharmacology (05.02.2022)
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Journal Article
Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine
Kiss, Béla, Némethy, Zsolt, Fazekas, Károly, Kurkó, Dalma, Gyertyán, István, Sághy, Katalin, Laszlovszky, István, Farkas, Bence, Kirschner, Norbert, Bolf-Terjéki, Etelka, Balázs, Ottilia, Lendvai, Balázs
Published in Drug design, development and therapy (01.09.2019)
Published in Drug design, development and therapy (01.09.2019)
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Journal Article
Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands
Éliás, Olivér, Kovács, Zoltán, Wágner, Gábor, Némethy, Zsolt, Tarcsay, Ákos, Greiner, István
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
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Journal Article
The influence of 5-HT2A activity on a 5-HT2C specific in vivo assay used for early identification of multiple acting SERT and 5-HT2C receptor ligands
Éliás, Olivér, Nógrádi, Katalin, Domány, György, Szakács, Zoltán, Kóti, János, Szántay, Csaba, Tarcsay, Ákos, Keserű, György M., Gere, Anikó, Kiss, Béla, Kurkó, Dalma, Kolok, Sándor, Némethy, Zsolt, Kapui, Zoltán, Hellinger, Éva, Vastag, Mónika, Sághy, Katalin, Kedves, Rita, Gyertyán, István
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
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Journal Article
Discovery of novel positive allosteric modulators of the alpha 7 nicotinic acetylcholine receptor: Scaffold hopping approach
Ledneczki, Istvan, Tapolcsanyi, Pal, Gabor, Eszter, Visegrady, Andras, Vass, Marton, Eles, Janos, Holm, Patrik, Horvath, Anita, Pocsai, Aniko, Maho, Sandor, Greiner, Istvan, Kramos, Balazs, Beni, Zoltan, Koti, Janos, Kancz, Anna E., Than, Marta, Kolok, Sandor, Laszy, Judit, Balazs, Ottilia, Bugovits, Gyula, Nagy, Jozsef, Vastag, Monika, Szajli, Agota, Bozo, Eva, Levay, Gyorgy, Lendvai, Balazs, Nemethy, Zsolt
Published in European journal of medicinal chemistry (15.03.2021)
Published in European journal of medicinal chemistry (15.03.2021)
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Journal Article
HTS-based discovery and optimization of novel positive allosteric modulators of the alpha 7 nicotinic acetylcholine receptor
Ledneczki, Istvan, Horvath, Anita, Tapolcsanyi, Pal, Eles, Janos, Molnar, Katalin Dudas, Vago, Istvan, Visegrady, Andras, Kiss, Laszlo, Szigetvari, Aron, Koti, Janos, Kramos, Balazs, Maho, Sandor, Holm, Patrik, Kolok, Sandor, Fodor, Laszlo, Than, Marta, Kostyalik, Diana, Balazs, Ottilia, Vastag, Monika, Greiner, Istvan, Levay, Gyorgy, Lendvai, Balazs, Nemethy, Zsolt
Published in European journal of medicinal chemistry (15.10.2021)
Published in European journal of medicinal chemistry (15.10.2021)
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Journal Article
스피로크로만 유도체
HORVATH ANITA, LEVAY GYORGY ISTVAN, LEDNECZKI ISTVAN, DUDASNE MOLNAR KATALIN, NEMETHY ZSOLT, TAPOLCSANYI PAL, ELES JANOS
Year of Publication 25.03.2021
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Year of Publication 25.03.2021
Patent
The influence of 5-HT sub(2A) activity on a 5-HT sub(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT sub(2C) receptor ligands
Elias, Oliver, Nogradi, Katalin, Domany, Gyorgy, Szakacs, Zoltan, Koti, Janos, Szantay, Csaba Jr, Tarcsay, Akos, Keserue, Gyorgy M, Gere, Aniko, Kiss, Bela, Kurko, Dalma, Kolok, Sandor, Nemethy, Zsolt, Kapui, Zoltan, Hellinger, Eva, Vastag, Monika, Saghy, Katalin, Kedves, Rita, Gyertyan, Istvan
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
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Journal Article
티아디아진 유도체
LEVAY GYORGY ISTVAN, LEDNECZKI ISTVAN, SELENYI GYORGY, VISEGRADI ANDRAS, NEMETHY ZSOLT, TAPOLCSANYI PAL, ELES JANOS, GABOR ESZTER, PETRO JOZSEF LEVENTE, JABLONKAI ERSZEBET
Year of Publication 25.03.2021
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Year of Publication 25.03.2021
Patent
α7 Nicotinic acetylcholine receptors and their role in cognition
Lendvai, Balázs, Kassai, Ferenc, Szájli, Ágota, Némethy, Zsolt
Published in Brain research bulletin (01.04.2013)
Published in Brain research bulletin (01.04.2013)
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Journal Article
Discovery of Novel Steroid-Based Histamine H 3 Receptor Antagonists/Inverse Agonists
Ledneczki, István, Tapolcsányi, Pál, Gábor, Eszter, Éles, János, Barabás, Júlia, Béni, Zoltán, Varga, Balázs, Balázs, Ottilia, Román, Viktor, Fodor, László, Szikra, Judit, Vastag, Mónika, Lévay, György, Schmidt, Éva, Lendvai, Balázs, Greiner, István, Kiss, Béla, Némethy, Zsolt, Mahó, Sándor
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article