Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
Ducker, Gregory S., Ghergurovich, Jonathan M., Mainolfi, Nello, Suri, Vipin, Jeong, Stephanie K., Li, Sophia Hsin-Jung, Friedman, Adam, Manfredi, Mark G., Gitai, Zemer, Kim, Hahn, Rabinowitz, Joshua D.
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2017)
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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.
Published in Nature communications (14.01.2021)
Published in Nature communications (14.01.2021)
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
Ngo, Bryan, Kim, Eugenie, Osorio-Vasquez, Victoria, Doll, Sophia, Bustraan, Sophia, Liang, Roger J, Luengo, Alba, Davidson, Shawn M, Ali, Ahmed, Ferraro, Gino B, Fischer, Grant M, Eskandari, Roozbeh, Kang, Diane S, Ni, Jing, Plasger, Ariana, Rajasekhar, Vinagolu K, Kastenhuber, Edward R, Bacha, Sarah, Sriram, Roshan K, Stein, Benjamin D, Bakhoum, Samuel F, Snuderl, Matija, Cotzia, Paolo, Healey, John H, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Sabatini, David M, Jones, Drew R, Yu, Min, Zhao, Jean J, Jain, Rakesh K, Keshari, Kayvan R, Davies, Michael A, Vander Heiden, Matthew G, Hernando, Eva, Mann, Matthias, Cantley, Lewis C, Pacold, Michael E
Published in Cancer discovery (01.09.2020)
Published in Cancer discovery (01.09.2020)
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Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
Zhang, Yun, Jamison, Timothy F, Patel, Sejal, Mainolfi, Nello
Published in Organic letters (21.01.2011)
Published in Organic letters (21.01.2011)
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Journal Article
Serine Metabolism Supports Macrophage IL-1β Production
Rodriguez, Arianne E., Ducker, Gregory S., Billingham, Leah K., Martinez, Carlos A., Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark G., Weinberg, Samuel E., Rabinowitz, Joshua D., Chandel, Navdeep S.
Published in Cell metabolism (02.04.2019)
Published in Cell metabolism (02.04.2019)
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Serine Is an Essential Metabolite for Effector T Cell Expansion
Ma, Eric H., Bantug, Glenn, Griss, Takla, Condotta, Stephanie, Johnson, Radia M., Samborska, Bozena, Mainolfi, Nello, Suri, Vipin, Guak, Hannah, Balmer, Maria L., Verway, Mark J., Raissi, Thomas C., Tsui, Harmony, Boukhaled, Giselle, Henriques da Costa, Sofia, Frezza, Christian, Krawczyk, Connie M., Friedman, Adam, Manfredi, Mark, Richer, Martin J., Hess, Christoph, Jones, Russell G.
Published in Cell metabolism (07.02.2017)
Published in Cell metabolism (07.02.2017)
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Journal Article
Targeted protein degradation mechanisms
Zhang, Yi, Loh, Christine, Chen, Jesse, Mainolfi, Nello
Published in Drug discovery today. Technologies (01.04.2019)
Published in Drug discovery today. Technologies (01.04.2019)
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Journal Article
54020 Potent and selective TYK2 degraders, devoid of JAK activity, potently and completely suppress IL12/23 and IFN-a signaling pathways
Slavin, Anthony, Marx, Isaac, Wang, Amy, Byrne, Fergus, Wilkinson, Alex, Harsch, Andreas, Hu, Kan-Nian, Walther, Dirk, Karnik, Rahul, Mainolfi, Nello, Weiss, Matt
Published in Journal of the American Academy of Dermatology (01.09.2024)
Published in Journal of the American Academy of Dermatology (01.09.2024)
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53901 Potent and selective oral STAT6 degraders inhibit IL-4 and IL-13 functions in human cells and block TH2 inflammation in a mouse model of atopic dermatitis
Wang, Amy, Yang, Bin, Ramanathan, Anand, Hossain, Alamgir, Dong, Huijun, Follows, Bruce, Browne, Chris, Harsch, Andreas, Sawant, Rupa, Slavin, Anthony, Mainolfi, Nello
Published in Journal of the American Academy of Dermatology (01.09.2024)
Published in Journal of the American Academy of Dermatology (01.09.2024)
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Tu1488 POTENT AND SELECTIVE ORAL STAT6 DEGRADERS INHIBIT IL-4 AND IL-13 FUNCTIONS IUN HUMAN CELLS AND BLOCK TH2 INFLAMMATION IN VIVO IN A MOUSE MODEL
Wang, Amy, Yang, Bin, Ramanathan, Anand, Hossain, Alamgir, Dong, Huijun, Follows, Bruce, Browne, Chris, Harsch, Andreas, Sawant, Rupa, Enerson, Bradley E., Slavin, Anthony, Mainolfi, Nello
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases
Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Sweeney, Aengus Mac, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valérie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard J. H., Risitano, Antonio M., Karki, Rajeshri G., Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Hughes, Nicola, Smith, Thomas M., Cumin, Frederic, Argikar, Upendra A., Haraldsson, Börje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Jürgen, Flohr, Stefanie, Harrison, Richard, Eder, Jörg
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2019)
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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial
Ackerman, Lindsay, Acloque, Gerard, Bacchelli, Sandro, Schwartz, Howard, Feinstein, Brian J., La Stella, Phillip, Alavi, Afsaneh, Gollerkeri, Ashwin, Davis, Jeffrey, Campbell, Veronica, McDonald, Alice, Agarwal, Sagar, Karnik, Rahul, Shi, Kelvin, Mishkin, Aimee, Culbertson, Jennifer, Klaus, Christine, Enerson, Bradley, Massa, Virginia, Kuhn, Eric, Sharma, Kirti, Keaney, Erin, Barnes, Randy, Chen, Dapeng, Zheng, Xiaozhang, Rong, Haojing, Sabesan, Vijay, Ho, Chris, Mainolfi, Nello, Slavin, Anthony, Gollob, Jared A.
Published in Nature medicine (01.12.2023)
Published in Nature medicine (01.12.2023)
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STAT3 degraders inhibit cellular activation, cytokine production, and Th17 development, resulting in inhibition of autoimmunity in the MOG-EAE model of CNS inflammation
Sullivan, Jeffrey, Brown, Crystal, Mayo, Michele, Dixit, Vaishali, Enerson, Bradley, Rong, Haojing, Yang, Bin, De Savi, Chris, Gollob, Jared, Mainolfi, Nello, Slavin, Anthony, Hubeau, Cedric
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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Discovery of KT-474a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases
Zheng, Xiaozhang, Ji, Nan, Campbell, Veronica, Slavin, Anthony, Zhu, Xiao, Chen, Dapeng, Rong, Haojing, Enerson, Brad, Mayo, Michele, Sharma, Kirti, Browne, Chris M., Klaus, Christine R., Li, Haoran, Massa, Ginny, McDonald, Alice A., Shi, Yatao, Sintchak, Mike, Skouras, Stephanie, Walther, Dirk M., Yuan, Karen, Zhang, Yi, Kelleher, Joe, Liu, Guang, Luo, Xinbo, Mainolfi, Nello, Weiss, Matthew M.
Published in Journal of medicinal chemistry (24.10.2024)
Published in Journal of medicinal chemistry (24.10.2024)
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Journal Article
Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B‑Cell Lymphoma
Weiss, Matthew M., Zheng, Xiaozhang, Ji, Nan, Browne, Chris M., Campbell, Veronica, Chen, Dapeng, Enerson, Brad, Fei, Xue, Huang, Xin, Klaus, Christine R., Li, Haoran, Mayo, Michele, McDonald, Alice A., Paul, Atanu, Rong, Haojing, Sharma, Kirti, Shi, Yatao, Slavin, Anthony, Walther, Dirk M., Yuan, Karen, Zhang, Yi, Zhu, Xiao, Kelleher, Joe, Walker, Duncan, Mainolfi, Nello
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Journal Article
Selective IRAK4 degradation, not kinase inhibition, blocks TLR-activated NF-Kb and p38 Signaling leading to broad cytokine inhibition
Skouras, Stephanie M, Massa, Virginia, Lurier, Emily, Hubeau, Cedric, Wang, Amy, Zheng, Xiaozhang, Sharma, Kirti, Walter, Dirk, Browne, Chris, Mayo, Michele, Fitzgerald, Michael, McDonald, Alice, Gollob, Jared, Mainolfi, Nello, Slavin, Anthony, Campbell, Veronica
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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