2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
Banerjee, Soojay, Bartesaghi, Alberto, Merk, Alan, Rao, Prashant, Bulfer, Stacie L., Yan, Yongzhao, Green, Neal, Mroczkowski, Barbara, Neitz, R. Jeffrey, Wipf, Peter, Falconieri, Veronica, Deshaies, Raymond J., Milne, Jacqueline L. S., Huryn, Donna, Arkin, Michelle, Subramaniam, Sriram
Published in Science (American Association for the Advancement of Science) (19.02.2016)
Published in Science (American Association for the Advancement of Science) (19.02.2016)
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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
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Published in PLoS pathogens (01.07.2015)
Published in PLoS pathogens (01.07.2015)
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Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni
Long, Thavy, Neitz, R Jeffrey, Beasley, Rachel, Kalyanaraman, Chakrapani, Suzuki, Brian M, Jacobson, Matthew P, Dissous, Colette, McKerrow, James H, Drewry, David H, Zuercher, William J, Singh, Rahul, Caffrey, Conor R
Published in PLoS neglected tropical diseases (01.01.2016)
Published in PLoS neglected tropical diseases (01.01.2016)
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Lead identification to clinical candidate selection: drugs for Chagas disease
Neitz, R Jeffrey, Chen, Steven, Supek, Frantisek, Yeh, Vince, Kellar, Danielle, Gut, Jiri, Bryant, Clifford, Gallardo-Godoy, Alejandra, Molteni, Valentina, Roach, Steven L, Khare, Shilpi, Stinson, Monique, Chatterjee, Arnab K, Robertson, Stephanie, Renslo, Adam R, Arkin, Michelle, Glynne, Richard, McKerrow, James, Siqueira-Neto, Jair L
Published in Journal of biomolecular screening (01.01.2015)
Published in Journal of biomolecular screening (01.01.2015)
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TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling
Wolfe, Alan R., Neitz, R. Jeffrey, Burlingame, Mark, Suzuki, Brian M., Lim, KC, Scheideler, Mark, Nelson, David L., Benet, Leslie Z., Caffrey, Conor R.
Published in International journal for parasitology -- drugs and drug resistance (01.12.2018)
Published in International journal for parasitology -- drugs and drug resistance (01.12.2018)
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Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway
Alverez, Celeste, Bulfer, Stacie L, Chakrasali, Ramappa, Chimenti, Michael. S, Deshaies, Raymond J, Green, Neal, Kelly, Mark, LaPorte, Matthew G, Lewis, Taber S, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Peshkov, Vsevolod A, Walters, Michael A, Zhang, Feng, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors
Bowers, Simeon, Truong, Anh P., Ye, Michael, Aubele, Danielle L., Sealy, Jennifer M., Neitz, R. Jeffrey, Hom, Roy K., Chan, Wayman, Dappen, Michael S., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Zhu, Yong L., Beroza, Paul, Tonn, George, Zhang, Heather, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Pandya, Deepal, Diep, Linnea, Fitzgerald, Kent, Artis, Dean R., Anderson, John P., Bergeron, Marcelle
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
Bowers, Simeon, Truong, Anh P., Jeffrey Neitz, R., Hom, Roy K., Sealy, Jennifer M., Probst, Gary D., Quincy, David, Peterson, Brian, Chan, Wayman, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Lin, May, Yao, Nanhua, Artis, Dean R., Zhang, Heather, Chen, Linda, Dryer, Mark, Samant, Bhushan, Zmolek, Wes, Wong, Karina, Lorentzen, Colin, Goldbach, Erich, Tonn, George, Quinn, Kevin P., Sauer, John-Michael, Wright, Sarah, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones
SHENAI, Bhaskar R, LEE, Belinda J, ALVAREZ-HERNANDEZ, Alejandro, CHONG, Pek Y, EMAL, Cory D, NEITZ, R. Jeffrey, ROUSH, William R, ROSENTHAL, Philip J
Published in Antimicrobial Agents and Chemotherapy (01.01.2003)
Published in Antimicrobial Agents and Chemotherapy (01.01.2003)
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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor
Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2
Gahbauer, Stefan, Correy, Galen J, Schuller, Marion, Ferla, Matteo P, Doruk, Yagmur Umay, Rachman, Moira, Wu, Taiasean, Diolaiti, Morgan, Wang, Siyi, Neitz, R Jeffrey, Fearon, Daren, Radchenko, Dmytro S, Moroz, Yurii S, Irwin, John J, Renslo, Adam R, Taylor, Jenny C, Gestwicki, Jason E, von Delft, Frank, Ashworth, Alan, Ahel, Ivan, Shoichet, Brian K, Fraser, James S
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2023)
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Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement
Neitz, R. Jeffrey, Konradi, Andrei W., Sham, Hing L., Zmolek, Wes, Wong, Karina, Qin, Ann, Lorentzen, Colin, Nakamura, David, Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Chereau, David, Ren, Zhao, Anderson, John, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments
Konstantinidou, Markella, Visser, Emira J., Vandenboorn, Edmee, Chen, Sheng, Jaishankar, Priyadarshini, Overmans, Maurits, Dutta, Shubhankar, Neitz, R. Jeffrey, Renslo, Adam R., Ottmann, Christian, Brunsveld, Luc, Arkin, Michelle R.
Published in Journal of the American Chemical Society (20.09.2023)
Published in Journal of the American Chemical Society (20.09.2023)
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From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking
Visser, Emira J., Jaishankar, Priyadarshini, Sijbesma, Eline, Pennings, Marloes A. M., Vandenboorn, Edmee M. F., Guillory, Xavier, Neitz, R. Jeffrey, Morrow, John, Dutta, Shubhankar, Renslo, Adam R., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian
Published in Angewandte Chemie International Edition (11.09.2023)
Published in Angewandte Chemie International Edition (11.09.2023)
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A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers
Kenanova, Dyana N., Visser, Emira J., Virta, Johanna M., Sijbesma, Eline, Centorrino, Federica, Vickery, Holly R., Zhong, Mengqi, Neitz, R. Jeffrey, Brunsveld, Luc, Ottmann, Christian, Arkin, Michelle R.
Published in ACS central science (24.05.2023)
Published in ACS central science (24.05.2023)
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Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97
Alverez, Celeste, Arkin, Michelle R, Bulfer, Stacie L, Colombo, Raffaele, Kovaliov, Marina, LaPorte, Matthew G, Lim, Chaemin, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Yan, Yongzhao, Yue, Zhizhou, Huryn, Donna M, Wipf, Peter
Published in ACS medicinal chemistry letters (10.12.2015)
Published in ACS medicinal chemistry letters (10.12.2015)
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Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas’ disease
Neitz, R. Jeffrey, Bryant, Clifford, Chen, Steven, Gut, Jiri, Hugo Caselli, Estefania, Ponce, Servando, Chowdhury, Somenath, Xu, Haichao, Arkin, Michelle R., Ellman, Jonathan A., Renslo, Adam R.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening
Ortiz, Gloria, Longbotham, James E, Qin, Sophia L, Zhang, Meng Yao, Lee, Gregory M, Neitz, R. Jeffrey, Kelly, Mark J. S, Arkin, Michelle R, Fujimori, Danica Galoni
Published in RSC chemical biology (06.03.2024)
Published in RSC chemical biology (06.03.2024)
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Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97
LaPorte, Matthew G, Burnett, James C, Colombo, Raffaele, Bulfer, Stacie L, Alverez, Celeste, Chou, Tsui-Fen, Neitz, R. Jeffrey, Green, Neal, Moore, William J, Yue, Zhizhou, Li, Shan, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
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Journal Article
From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking
Visser, Emira J., Jaishankar, Priyadarshini, Sijbesma, Eline, Pennings, Marloes A. M., Vandenboorn, Edmee M. F., Guillory, Xavier, Neitz, R. Jeffrey, Morrow, John, Dutta, Shubhankar, Renslo, Adam R., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian
Published in Angewandte Chemie (11.09.2023)
Published in Angewandte Chemie (11.09.2023)
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