In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)
Parmentier, Julie M, Voss, Jeff, Graff, Candace, Schwartz, Annette, Argiriadi, Maria, Friedman, Michael, Camp, Heidi S, Padley, Robert J, George, Jonathan S, Hyland, Deborah, Rosebraugh, Matthew, Wishart, Neil, Olson, Lisa, Long, Andrew J
Published in BMC rheumatology (01.01.2018)
Published in BMC rheumatology (01.01.2018)
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Phase II Study of ABT‐122, a Tumor Necrosis Factor– and Interleukin‐17A–Targeted Dual Variable Domain Immunoglobulin, in Patients With Psoriatic Arthritis With an Inadequate Response to Methotrexate
Mease, Philip J., Genovese, Mark C., Weinblatt, Michael E., Peloso, Paul M., Chen, Kun, Othman, Ahmed A., Li, Yihan, Mansikka, Heikki T., Khatri, Amit, Wishart, Neil, Liu, John
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2018)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2018)
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Cell-Type and Stimulus Determine the Impact of the Serine/Threonine Kinase Cot/Tpl2 in Acute and Chronic Inflammation
Murtaza, Anwar, Senior Scientist, Abbott Bioresearch Center, Pharmacology, Worcester, MA, Bryant, Shaughn, Research Associate, Abbott Bioresearch Center, Pharmacology, Worcester, MA, Mathieu, Suzanne, Research Associate, Abbott Bioresearch Center, Pharmacology, Worcester, MA, Allen, Hamish, Director, Abbott Bioresearch Center, Molecular and Cellular Biology, Worcester, MA, Tripp, Catherine, Senior Director, Abbott Bioresearch Center, Worcester, MA, Wishart, Neil, Associate Director, Abbott Bioresearch Center, Chemistry, Worcester, MA
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
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Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors
Friedman, Michael, Frank, Kristine E., Aguirre, Ana, Argiriadi, Maria A., Davis, Heather, Edmunds, Jeremy J., George, Dawn M., George, Jonathan S., Goedken, Eric, Fiamengo, Bryan, Hyland, Deborah, Li, Bin, Murtaza, Anwar, Morytko, Michael, Somal, Gagandeep, Stewart, Kent, Tarcsa, Edit, Van Epps, Stacy, Voss, Jeffrey, Wang, Lu, Woller, Kevin, Wishart, Neil
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
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Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H-4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models
Cowart, Marlon D., Altenbach, Robert J., Liu, Huaqing, Hsieh, Gin C., Drizin, Irene, Milicic, Ivan, Miller, Thomas R., Witte, David G., Wishart, Neil, Fix-Stenzel, Shannon R., McPherson, Michael J., Adair, Ronald M., Wetter, Jill M., Bettencourt, Brian M., Marsh, Kerman C., Sullivan, James P., Honore, Prisca, Esbenshade, Timothy A., Brioni, Jorge D.
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Design and synthesis of tricyclic cores for kinase inhibition
Van Epps, Stacy, Fiamengo, Bryan, Edmunds, Jeremy, Ericsson, Anna, Frank, Kristine, Friedman, Michael, George, Dawn, George, Jonathan, Goedken, Eric, Kotecki, Brian, Martinez, Gloria, Merta, Philip, Morytko, Michael, Shekhar, Shashank, Skinner, Barbara, Stewart, Kent, Voss, Jeffrey, Wallace, Grier, Wang, Lu, Wishart, Neil
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Syk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas
Long, Andrew J, Sampson, Erik, McCarthy, Richard W, Harris, Christopher M, Barnard, Marc, Shi, Dan, Conlon, Donna, Caldwell, Robert, Honor, David, Wishart, Neil, Hoemann, Michael, Duggan, Lori, Fritz, Douglas, Stedman, Christopher, O'Connor, Elizabeth, Mikaelian, Igor, Schwartz, Annette
Published in Toxicologic pathology (01.10.2016)
Published in Toxicologic pathology (01.10.2016)
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Journal Article
Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models
Cowart, Marlon D, Altenbach, Robert J, Liu, Huaqing, Hsieh, Gin C, Drizin, Irene, Milicic, Ivan, Miller, Thomas R, Witte, David G, Wishart, Neil, Fix-Stenzel, Shannon R, McPherson, Michael J, Adair, Ronald M, Wetter, Jill M, Bettencourt, Brian M, Marsh, Kennan C, Sullivan, James P, Honore, Prisca, Esbenshade, Timothy A, Brioni, Jorge D
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Journal Article
Structure-Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H-4 Receptor Ligands
Altenbach, Robert J., Adair, Ronald M., Bettencourt, Brian M., Black, Lawrence A., Fix-Stenzel, Shannon R., Gopalakrishnan, Suiatha M., Hsieh, Gin C., Liu, Huaqing, Marsh, Kennan C., McPherson, Michael J., Milicic, Ivan, Miller, Thomas R., Vortherms, Timothy A., Warrior, Usha, Wetter, Jill M., Wishart, Neil, Witte, David G., Honore, Prisca, Esbenshade, Timothy A., Hancock, Arthur A., Brioni, Jorge D., Cowart, Marlon D.
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Journal Article
Thienopyrimidine Ureas as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors
Dai, Yujia, Guo, Yan, Frey, Robin R, Ji, Zhiqin, Curtin, Michael L, Ahmed, Asma A, Albert, Daniel H, Arnold, Lee, Arries, Shannon S, Barlozzari, Teresa, Bauch, Joy L, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George A, Glaser, Keith B, Guo, Jun, Li, Junling, Marcotte, Patrick A, Marsh, Kennan C, Moskey, Maria D, Pease, Lori J, Stewart, Kent D, Stoll, Vincent S, Tapang, Paul, Wishart, Neil, Davidsen, Steven K, Michaelides, Michael R
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Journal Article
Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4 Receptor Ligands
Altenbach, Robert J, Adair, Ronald M, Bettencourt, Brian M, Black, Lawrence A, Fix-Stenzel, Shannon R, Gopalakrishnan, Sujatha M, Hsieh, Gin C, Liu, Huaqing, Marsh, Kennan C, McPherson, Michael J, Milicic, Ivan, Miller, Thomas R, Vortherms, Timothy A, Warrior, Usha, Wetter, Jill M, Wishart, Neil, Witte, David G, Honore, Prisca, Esbenshade, Timothy A, Hancock, Arthur A, Brioni, Jorge D, Cowart, Marlon D
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Journal Article
Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production
Cusack, Kevin, Allen, Hamish, Bischoff, Agnieszka, Clabbers, Anca, Dixon, Richard, Fix-Stenzel, Shannon, Friedman, Michael, Gaumont, Yvette, George, Dawn, Gordon, Thomas, Grongsaard, Pintipa, Janssen, Bernd, Jia, Yong, Moskey, Maria, Quinn, Christopher, Salmeron, Andres, Thomas, Christine, Wallace, Grier, Wishart, Neil, Yu, Zhengtian
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Minimum significant ratio of selectivity ratios (MSRSR) and confidence in ratio of selectivity ratios (CRSR): quantitative measures for selectivity ratios obtained by screening assays
Goedken, Eric R, Devanarayan, Viswanath, Harris, Christopher M, Dowding, Lori A, Jakway, James P, Voss, Jeffrey W, Wishart, Neil, Jordan, David C, Talanian, Robert V
Published in Journal of biomolecular screening (01.08.2012)
Published in Journal of biomolecular screening (01.08.2012)
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Journal Article
Discovery of thieno[2,3- c]pyridines as potent COT inhibitors
George, Dawn, Friedman, Michael, Allen, Hamish, Argiriadi, Maria, Barberis, Claude, Bischoff, Agnieszka, Clabbers, Anca, Cusack, Kevin, Dixon, Richard, Fix-Stenzel, Shannon, Gordon, Thomas, Janssen, Bernd, Jia, Yong, Moskey, Maria, Quinn, Christopher, Salmeron, Jose-Andres, Wishart, Neil, Woller, Kevin, Yu, Zhengtian
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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Journal Article
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization
Harris, Christopher M., Ericsson, Anna M., Argiriadi, Maria A., Barberis, Claude, Borhani, David W., Burchat, Andrew, Calderwood, David J., Cunha, George A., Dixon, Richard W., Frank, Kristine E., Johnson, Eric F., Kamens, Joanne, Kwak, Silvia, Li, Biqin, Mullen, Kelly D., Perron, Denise C., Wang, Lu, Wishart, Neil, Wu, Xiaoyun, Zhang, Xiaolei, Zmetra, Tami R., Talanian, Robert V.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor
Argiriadi, Maria A, Goedken, Eric R, Banach, David, Borhani, David W, Burchat, Andrew, Dixon, Richard W, Marcotte, Doug, Overmeyer, Gary, Pivorunas, Valerie, Sadhukhan, Ramkrishna, Sousa, Silvino, Moore, Nigel St John, Tomlinson, Medha, Voss, Jeffrey, Wang, Lu, Wishart, Neil, Woller, Kevin, Talanian, Robert V
Published in BMC structural biology (20.09.2012)
Published in BMC structural biology (20.09.2012)
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Comparative analysis of various in vitro COT kinase assay formats and their applications in inhibitor identification and characterization
Jia, Yong, Quinn, Christopher M., Clabbers, Anca, Talanian, Robert, Xu, Yajun, Wishart, Neil, Allen, Hamish
Published in Analytical biochemistry (15.03.2006)
Published in Analytical biochemistry (15.03.2006)
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NOVEL TRICYCLIC COMPOUNDS
ERIC R GOEDKEN, MICHAEL J MORYTKO, NEIL WISHART, MARIA A ARGIRIRADI, DAVID J CALDERWOOD, ERICSSON ANNA M, VOSS JEFFREY W, FRIEDMAN MICHAEL, KENT D STEWART, WANG LU, DAWN M GEORGE, BIQIN C LI, BRYAN A FIAMENGO, GRIER AWALLACE, NATHAN S JOSEPHSOHN, KRISTINE E FRANK, KEVIN R WOLLER
Year of Publication 05.01.2017
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Year of Publication 05.01.2017
Patent
NOVEL TRICYCLIC COMPOUNDS
ERIC R GOEDKEN, MICHAEL J MORYTKO, NEIL WISHART, MARIA A ARGIRIRADI, DAVID J CALDERWOOD, ERICSSON ANNA M, VOSS JEFFREY W, FRIEDMAN MICHAEL, KENT D STEWART, WANG LU, DAWN M GEORGE, BIQIN C LI, BRYAN A FIAMENGO, GRIER AWALLACE, NATHAN S JOSEPHSOHN, KRISTINE E FRANK, KEVIN R WOLLER
Year of Publication 10.09.2015
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Year of Publication 10.09.2015
Patent