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Published in Chemical & pharmaceutical bulletin (1999)
Published in Chemical & pharmaceutical bulletin (1999)
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Synthesis of a New Dual Metalloprotease Inhibitor. I. Diastereoselective Alkylation of Protected 6-Oxopipecolic Acid Esters
AKASAKA, Kozo, AKAMATSU, Hiroshi, KIMOTO, Yuichi, KOMATSU, Yuki, SHIMIZU, Toshikazu, SHIMOMURA, Naoyuki, TAGAMI, Katsuya, NEGI, Shigeto
Published in Chemical & pharmaceutical bulletin (1999)
Published in Chemical & pharmaceutical bulletin (1999)
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STUDIES ON ORALLY ACTIVE CEPHALOSPORINS: I. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NEW 3-SUBSTITUTED CARBAMOYLOXYMETHYL CEPHALOSPORINS
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Published in Journal of antibiotics (1994)
Published in Journal of antibiotics (1994)
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Studies on the Stability of .DELTA.2 and .DELTA.3 Cephem Esters. II. Comparative Stability Studies of .DELTA.2 and .DELTA.3 Cephems at Various pHs and the Degradation Process of .DELTA.2 Cephem Esters
NEGI, Shigeto, YAMANAKA, Motosuke, KOMATSU, Yuki, TSURUOKA, Akihiko, TSUKADA, Itaru, MINAMI, Norio
Published in Chemical & pharmaceutical bulletin (1995)
Published in Chemical & pharmaceutical bulletin (1995)
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A Practical Synthetic Method for 3-(N,N-Disubstituted Carbamoyloxy)methyl Cephems without Generating the .DELTA.2-Isomers
NEGI, Shigeto, YAMANAKA, Motosuke, KOMATSU, Yuki, TSURUOKA, Akihiko, KAMADA, Atsushi, TSUKADA, Itaru, MACHIDA, Yoshimasa
Published in Chemical & pharmaceutical bulletin (1995)
Published in Chemical & pharmaceutical bulletin (1995)
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Studies on the Stability of .DELTA.2 and .DELTA.3 Cephem Esters. I. Marked Difference in Stability between .DELTA.2 and .DELTA.3 Cephem Prodrug Esters and Application to the Preparation of Key Intermediates for Oral Cephem Synthesis
NEGI, Shigeto, YAMANAKA, Mototuske, KOMATSU, Yuki, TSURUOKA, Akihiko, TSUKADA, Itaru, MINAMI, Norio
Published in Chemical & pharmaceutical bulletin (1995)
Published in Chemical & pharmaceutical bulletin (1995)
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Studies on orally active cephalosporins. II. Synthesis and structure-activity relations of new ((E) or (Z) 3-substituted carbamoyloxy)-1-propenyl cephalosporins
NEGI, SHIGETO, SASHO, MANABU, YAMANAKA, MOTOSUKE, SUGIYAMA, ISAO, KOMATSU, YUKI, TSURUOKA, AKIHIKO, KAMADA, ATSUSHI, TSUKADA, ITARU, HIRUMA, RYOICHI, KATSU, KANEMASA, MACHIDA, YOSHIMASA
Published in Journal of antibiotics (1994)
Published in Journal of antibiotics (1994)
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Large scale synthesis of N-benzyl-4-formylpiperidine through partial reduction of esters using aluminum hydride reagents modified with pyrrolidine
Abe, Taichi, Haga, Toyokazu, Negi, Shigeto, Morita, Yukio, Takayanagi, Keizou, Hamamura, Kimio
Published in Tetrahedron (02.04.2001)
Published in Tetrahedron (02.04.2001)
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PROCESS FOR PRODUCTION OF WATER-SOLUBLE AZOLE PRODRUG
SASHO, MANABU, MIYAZAWA, MAMORU, SATO, KEIZO, NEGI, SHIGETO, KAMADA, ATSUSHI, NIIJIMA, JUN
Year of Publication 28.06.2007
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Year of Publication 28.06.2007
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PYRROLIDINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
NAKA, HIROYUKI, SASYOU, MANABU, KAYANO, AKIO, NEGI, SHIGETO, HAGA, TOYOKAZU
Year of Publication 24.10.2002
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Year of Publication 24.10.2002
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PROCESS FOR PRODUCTION OF PYRAZOLE-FUSED RING DERIVATIVES
HOSHINO, YORIHISA, SHIMIZU, TOSHIKAZU, SASHO, MANABU, KURODA, HIROSHI, KUBOTA, MANABU, NEGI, SHIGETO, SHIMOMURA, NAOYUKI
Year of Publication 27.10.2005
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Year of Publication 27.10.2005
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CALCIUM BIS[(2S)-3-[3-[(2S)-3-(4-CHLORO-2-CYANOPHENOXY)-2- FLUOROPROPOXY]PHENYL]-2-ISOPROPOXYPROPIONATE] AND INTERMEDIATE THEREOF
HISATAKE, YOSHIHIKO, SASHO, MANABU, INOUE, SUSUMU, MATSUYAMA, KEISUKE, HAYASHI, KENJI, GOTODA, MASAHARU, INOUE, TORU, TAKIGAWA, TEIJI, NEGI, SHIGETO, OZEKI, NAOKI, MURATA, KAORU, MIYAZAWA, MAMORU, MATSUURA, FUMIYOSHI, NISHIURA, KATSUTOSHI, SHINODA, MASANOBU
Year of Publication 02.11.2006
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Year of Publication 02.11.2006
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PROCESS FOR THE PREPARATION OF BASIC ANTIBIOTIC-INORGANIC ACID ADDITION SALTS AND INTERMEDIATE OXALATES
NAKAMURA, TAIJU, SASHO, MANABU, SAITO, HIROYUKI, SATO, NOBUAKI, CHIBA, HIROYUKI, ISHIZUKA, HIROYUKI, KAYANO, AKIO, KOMATSU, YUUKI, NEGI, SHIGETO, SAKURAI, SHIN
Year of Publication 08.02.2001
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Year of Publication 08.02.2001
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CEPHALOSPORIN DERIVATIVES
NAITO, TOSHIHIKO, MACHIDA, YOSHIMASA, YAMAUCHI, HIROSHI, KAMIYA, TAKASHI, KOMATSU, YUUKI, NOMOTO, SEIICHIRO, NEGI, SHIGETO, SUGIYAMA, ISAO
Year of Publication 02.07.1987
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Year of Publication 02.07.1987
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