Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index
Lyon, Robert P, Bovee, Tim D, Doronina, Svetlana O, Burke, Patrick J, Hunter, Joshua H, Neff-LaFord, Haley D, Jonas, Mechthild, Anderson, Martha E, Setter, Jocelyn R, Senter, Peter D
Published in Nature biotechnology (01.07.2015)
Published in Nature biotechnology (01.07.2015)
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The vedotin antibody-drug conjugate payload drives platform-based nonclinical safety and pharmacokinetic profiles
Neff-LaFord, Haley D, Carratt, Sarah A, Carosino, Christopher, Everds, Nancy, Cardinal, Kristen A, Duniho, Steven, Schutten, Melissa M, Frantz, Christopher, Zuch de Zafra, Christina, Harstad, Eric B
Published in Molecular cancer therapeutics (02.05.2024)
Published in Molecular cancer therapeutics (02.05.2024)
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Reversible Chemical Modification of Antibody Effector Function Mitigates Unwanted Systemic Immune Activation
Moquist, Philip N., Zhang, Xinqun, Leiske, Chris I., Eng-Duncan, Nicole M.-L., Zeng, Weiping, Bindman, Noah A., Wo, Serena W., Wong, Abbie, Henderson, Clark M., Crowder, Karalyne, Lyon, Robert, Doronina, Svetlana O., Senter, Peter D., Neff-LaFord, Haley D., Sussman, Django, Gardai, Shyra J., Levengood, Matthew R.
Published in Bioconjugate chemistry (19.06.2024)
Published in Bioconjugate chemistry (19.06.2024)
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Over expression of glutamate cysteine ligase increases cellular resistance to H2O2‐induced DNA single‐strand breaks
Shi, Shengli, Hudson, Francesca N., Botta, Dianne, McGrath, Monica B., White, Collin C., Neff‐LaFord, Haley D., Dabrowski, Michael J., Singh, Narendra P., Kavanagh, Terrance J.
Published in Cytometry. Part A (01.09.2007)
Published in Cytometry. Part A (01.09.2007)
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438 Synergy between SEA-CD40 and chemotherapeutics drives curative antitumor activity in preclinical models
Zeng, Weiping, Neff-LaFord, Haley, Ansari, Sahar, Jacquemont, Celine, Schmitt, Michael, Gardai, Shyra
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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783 SGN-PDL1V, a novel, investigational PD-L1-directed antibody-drug conjugate for the treatment of solid tumors
Kwan, Byron, Ramirez, Megan, Jin, Steven, Yu, Changpu, Wo, Serena, Gupta, Priyanka, Allred, Sean, Simmons, Jessica, Hensley, Kelly, Zafra, Christina Zuch de, Neff-LaFord, Haley, Hengel, Shawna, Forero-Torres, Andres, Epps, Heather Van
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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CD40 DOSAGE AND ADMINISTRATION OF NON-FUCOSYLATED ANTI-CD40 ANTIBODIES
NEFF LAFORD HALEY, GARDAI SHYRA, LAW CHE LEUNG, PENG STANFORD, YANG JING
Year of Publication 24.05.2024
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Year of Publication 24.05.2024
Patent
다발성 골수종 치료 방법
JACQUEMONT CELINE FABIENNE, LI HONG, NEFF LAFORD HALEY, VAN EPPS HEATHER, CAMPBELL MARY, TAFT DAVID
Year of Publication 09.01.2023
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Year of Publication 09.01.2023
Patent
CD40 DOSAGE AND ADMINISTRATION OF NON-FUCOSYLATED ANTI-CD40 ANTIBODIES
NEFF LAFORD HALEY, GARDAI SHYRA, LAW CHE LEUNG, PENG STANFORD, YANG JING
Year of Publication 27.06.2017
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Year of Publication 27.06.2017
Patent
Abstract 60: Reducing toxicity of antibody-drug conjugates through modulation of pharmacokinetics
Simmons, Jessica, Zapata, Francisco, Neff-Laford, Haley, Hunter, Joshua, Cochran, Julia, Burke, Patrick, Lyon, Robert P.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey
Collinge, Mark, Neff-LaFord, Haley, Akella, Surekha, Fogal, Birgit, Fraser, Kathryn, Jabbour, Jacob, Harper, Kirsty, Maier, Curtis C., Malherbe, Laurent, Marshall, Nikki, Rao, Gautham K., Raman, Kavita, Skaggs, Hollie, Weber, Felix, Fuller, Claudette L.
Published in Regulatory toxicology and pharmacology (01.06.2024)
Published in Regulatory toxicology and pharmacology (01.06.2024)
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EP064/#192 Potential mechanism for ocular adverse events observed with tisotumab vedotin
Vergote, Ignace, Kim, Stella, Ursell, Paul, Pignata, Sandro, Gonzalez-Martin, Antonio, Randall, Leslie, Melichar, Bohuslav, Madsen, Kristine, Mahner, Sven, Lorusso, Domenica, Henry, Stéphanie, Gaba, Lydia, Salcedo, Theodora, Neff-Laford, Haley, Harris, Jeffrey, Jiang, Joy, Soumaoro, Ibrahima, Jain, Shweta, Monk, Bradley, Coleman, Robert L
Published in International journal of gynecological cancer (04.12.2022)
Published in International journal of gynecological cancer (04.12.2022)
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Abstract 5535: SEA-CD40 is a non-fucosylated anti-CD40 antibody with potent pharmacodynamic activity in preclinical models and patients with advanced solid tumors
Neff-LaFord, Haley, Grilley-Olson, Juneko E., Smith, David C., Curti, Brendan, Goel, Sanjay, Kuzel, Timothy M., Markovic, Svetomir N., Rixe, Olivier, Bajor, David L., Gajewski, Thomas F., Gutierrez, Martin, Heath, Elisabeth I., Thompson, John, Ansari, Sahar, Gardai, Shyra, Jacquemont, Celine, Schmitt, Michael, Coveler, Andrew L.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 4994: SEA-CD40: from bench to bedside
Gardai, Shyra J., Neff-LaFord, Haley, Epp, Angela, Yang, Jing, Manley, Thomas, Law, Che-Leung
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 70: Elucidating the roles of antibody pharmacokinetics and maleimide stability in the toxicology of antibody-drug conjugates
Neff-LaFord, Haley, Zapata, Franciso, Schultz, Wendi, Balasubramanian, Cindy, Pittmen, Paul, Hengel, Shawna, Sanderson, Russell, Chemuturi, Nagendra, Setter, Jocelyn, Lyon, Robert P.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 4890: A novel topoisomerase I inhibitor antibody-drug conjugate targeting CEACAM5 has potent anti-tumor activity in colorectal cancer models
Baudat, Yves, Neff-LaFord, Haley, Nicolazzi, Celine, Meyer, Dave, Sigurjonsson, Johann Petur, Lyski, Ryan, Fantin, Valeria, Brun, Marie-Priscille, Chiron, Marielle, Decary, Stephanie
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 5668: Using clinical utility index (CUI) to determine the optimal biological dose of a nonfucosylated anti-TIGIT antibody: A proposed alternative to maximum tolerated dose (MTD)
Patilea-Vrana, Gabriela, Harrold, John, Ware, Joseph A., Lonning, Shaparak, Lee, Hun, Brooks, Lisa, Neff-LaFord, Haley, Hanley, William D., Forero-Torres, Andres
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 2472: SEA-CD40, a sugar engineered non-fucosylated anti-CD40 antibody with improved immune activating capabilities
Gardai, Shyra J., Epp, Angela, Linares, Germein, Westendorf, Lori, Sutherland, May, Neff-LaFord, Haley, Peng, Stanford L., Law, Che-Leung
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 2656: Reversible chemical modification of antibodies: A complementary approach to tuning FcγR binding that maintains anti-tumor activity while mitigating peripheral immune activation
Moquist, Philip N., Leiske, Chris I., Bindman, Noah A., Zhang, Xinqun, Duncan, Nicole, Zeng, Weiping, Wo, Serena W., Wong, Abbie, Henderson, Clark M., Crowder, Karalyne, Neff-LaFord, Haley D., Sussman, Django, Gardai, Shyra J., Levengood, Matthew R.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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