Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors
Logan, Kaitlyn M., Kaplan, Will, Simov, Vladimir, Zhou, Hua, Li, Derun, Torres, Luis, Morriello, Gregori J., Acton, John J., Pio, Barbara, Chen, Yi-Heng, Keylor, Mitchell H., Johnson, Rebecca, Kattar, Solomon D., Chau, Ryan, Yan, Xin, Ardolino, Michael, Zarate, Cayetana, Otte, Karin M., Palte, Rachel L., Xiong, Tina, McMinn, Spencer E., Lin, Shishi, Neelamkavil, Santhosh F., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Woodhouse, Janice D., Moy, Lily Y., Ciaccio, Paul J., Piesvaux, Jennifer, Zebisch, Matthias, Henry, Clare, Barker, John, Wood, Harold B., Kennedy, Matthew E., DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.
Published in Journal of medicinal chemistry (04.09.2024)
Published in Journal of medicinal chemistry (04.09.2024)
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Journal Article
Discovery of MK-8282 as a Potent G‑Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes
Neelamkavil, Santhosh F, Stamford, Andrew W, Kowalski, Timothy, Biswas, Dipshikha, Boyle, Craig, Chackalamannil, Samuel, Xia, Yan, Jayne, Charles, Neustadt, Bernard, Hao, Jinsong, Liu, Hong, Dai, Xing, Baker, Hana, Hawes, Brian, O’Neill, Kim, Tang, Huadong, Greenlee, William J
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
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Journal Article
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor
Neelamkavil, Santhosh F, Agrawal, Sony, Bara, Thomas, Bennett, Chad, Bhat, Sathesh, Biswas, Dipshikha, Brockunier, Linda, Buist, Nicole, Burnette, Duane, Cartwright, Mark, Chackalamannil, Samuel, Chase, Robert, Chelliah, Mariappan, Chen, Austin, Clasby, Martin, Colandrea, Vincent J, Davies, Ian W, Eagen, Keith, Guo, Zhuyan, Han, Yongxin, Howe, John, Jayne, Charles, Josien, Hubert, Kargman, Stacia, Marcantonio, Karen, Miao, Shouwu, Miller, Randy, Nolting, Andrew, Pinto, Patrick, Rajagopalan, Murali, Ruck, Rebecca T, Shah, Unmesh, Soriano, Aileen, Sperbeck, Donald, Velazquez, Francisco, Wu, Jin, Xia, Yan, Venkatraman, Srikanth
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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Journal Article
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors
Keylor, Mitchell H, Gulati, Anmol, Kattar, Solomon D, Johnson, Rebecca E, Chau, Ryan W, Margrey, Kaila A, Ardolino, Michael J, Zarate, Cayetana, Poremba, Kelsey E, Simov, Vladimir, Morriello, Gregori J, Acton, John J, Pio, Barbara, Yan, Xin, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Lesburg, Charles A, Adpressa, Donovon, Lin, Shishi, Neelamkavil, Santhosh, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul J, Piesvaux, Jennifer, Otte, Karin M, Wood, Harold B, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Journal Article
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Journal Article
Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants
Hussain, Zahid, Cooke, Andrew J., Neelamkavil, Santhosh, Brown, Lindsay, Carswell, Emma, Geissler, Wayne M., Guo, Zhuyan, Hawes, Brian, Kelly, Terri M., Kiyoi, Yasuko, Lai, KehDih, Lesburg, Charles, Pow, Eleanor, Zang, Yi, Wood, Harold B., Edmondson, Scott D., Liu, Weiguo
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease
Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Journal Article
Discovery of hydroxy pyrimidine Factor IXa inhibitors
Jayne, Charles L., Andreani, Teresa, Chan, Tin-Yau, Chelliah, Mariappan V., Clasby, Martin C., Dwyer, Michael, Eagen, Keith A., Fried, Steve, Greenlee, William J., Guo, Zhuyan, Hawes, Brian, Hruza, Alan, Ingram, Richard, Keertikar, Kartik M., Neelamkavil, Santhosh, Reichert, Paul, Xia, Yan, Chackalamannil, Samuel
Published in Bioorganic & medicinal chemistry letters (01.08.2020)
Published in Bioorganic & medicinal chemistry letters (01.08.2020)
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Journal Article
인터류킨-23 수용체의 펩티드 억제제
COSTANTE ROBERTO, DANIEL JAMES, BHANDARI ASHOK, FREDERICK BRIAN, INGENITO RAFFAELE, TRAN TRAN TRUNG, HENDRICK CHARLES, BIANCHI ELISABETTA, PATCH RAYMOND J, BARROS STEPHANIE A, ZHANG JING, SUN CHENGZAO, NEELAMKAVIL SANTHOSH, SOMANI SANDEEP, BRANCA DANILA
Year of Publication 13.03.2024
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Year of Publication 13.03.2024
Patent
인터류킨-23 수용체의 바이사이클릭 펩티드 억제제
COSTANTE ROBERTO, ZHANG JIE, BHANDARI ASHOK, FREDERICK BRIAN, INGENITO RAFFAELE, TRAN TRAN TRUNG, HENDRICK CHARLES, BIANCHI ELISABETTA, PATCH RAYMOND J, BARROS STEPHANIE A, ZHANG JING, SUN CHENGZAO, NEELAMKAVIL SANTHOSH, SOMANI SANDEEP, BRANCA DANILA
Year of Publication 13.03.2024
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Year of Publication 13.03.2024
Patent
인터류킨-23 수용체의 지질화된 펩티드 억제제
COSTANTE ROBERTO, DANIEL JAMES, BHANDARI ASHOK, FREDERICK BRIAN, TRAN TRAN TRUNG, HENDRICK CHARLES, BIANCHI ELISABETTA, DEL RIZZO SONIA, PATCH RAYMOND J, BARROS STEPHANIE A, ZHANG JING, RIEXINGER DOUGLAS, ROSOLIA FEDERICA, SUN CHENGZAO, NEELAMKAVIL SANTHOSH, SOMANI SANDEEP, LOLLOBRIGIDA MARTINA, BRANCA DANILA
Year of Publication 13.03.2024
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Year of Publication 13.03.2024
Patent
Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors
Velázquez, Francisco, Chelliah, Mariappan, Clasby, Martin, Guo, Zhuyan, Howe, John, Miller, Randy, Neelamkavil, Santhosh, Shah, Unmesh, Soriano, Aileen, Xia, Yan, Venkatraman, Srikanth, Chackalamannil, Samuel, Davies, Ian W
Published in ACS medicinal chemistry letters (08.12.2016)
Published in ACS medicinal chemistry letters (08.12.2016)
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Journal Article
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael
Published in MedChemComm (21.07.2021)
Published in MedChemComm (21.07.2021)
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인터류킨-23 수용체의 펩티드 억제제의 조성물
DI PRETORO GIUSTINO, MASJEDIZADEH MOHAMMAD, KNIGHT BEVERLY M, BHANDARI ASHOK, CHENG XIAOLI, LI SHU, BROECKX GERALDINE, POLIDORI DAVID, MERTENS NATHALIE, SUN DAJUN, RAJAN GOPAL, NEELAMKAVIL SANTHOSH FRANCIS, LAI FELIX, MODI NISHIT, FOURIE ANNE M
Year of Publication 24.07.2023
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Year of Publication 24.07.2023
Patent
LRRK2 억제제로서의 N- 퀴나졸린-2-아민 유도체, 제약 조성물 및 그의 용도
FULLER PETER H, YU ELSIE C, GULATI ANMOL, JOHNSON REBECCA ELIZABETH, CHAU RYAN W, NEELAMKAVIL SANTHOSH F, KEYLOR MITCHELL H, MORRIELLO GREGORI J, YAN XIN, MARGREY KAILA A, ZARATE SAEZ CAYETANA CARMELA, ARDOLINO MICHAEL J, KATTAR SOLOMON D
Year of Publication 28.06.2022
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Year of Publication 28.06.2022
Patent
Fluorous Swern Reaction
Crich, David, Neelamkavil, Santhosh
Published in Journal of the American Chemical Society (01.08.2001)
Published in Journal of the American Chemical Society (01.08.2001)
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