Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening
Lountos, George T, Zhao, Xue Zhi, Kiselev, Evgeny, Tropea, Joseph E, Needle, Danielle, Pommier, Yves, Burke, Terrence R, Waugh, David S
Published in Nucleic acids research (04.11.2019)
Published in Nucleic acids research (04.11.2019)
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Journal Article
Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus
Giddings, Lesley-Ann, Lountos, George T, Kim, Kang Woo, Brockley, Matthew, Needle, Danielle, Cherry, Scott, Tropea, Joseph E, Waugh, David S
Published in PloS one (30.03.2021)
Published in PloS one (30.03.2021)
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Journal Article
Hyperthermia-triggered intracellular delivery of anticancer agent to HER2 + cells by HER2-specific affibody (ZHER2-GS-Cys)-conjugated thermosensitive liposomes (HER2 + affisomes)
Smith, Brandon, Lyakhov, Ilya, Loomis, Kristin, Needle, Danielle, Baxa, Ulrich, Yavlovich, Amichai, Capala, Jacek, Blumenthal, Robert, Puri, Anu
Published in Journal of controlled release (01.07.2011)
Published in Journal of controlled release (01.07.2011)
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Journal Article
Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1
Zhao, Xue Zhi, Wang, Wenjie, Lountos, George T., Tropea, Joseph E., Needle, Danielle, Pommier, Yves, Burke, Terrence R.
Published in Frontiers in chemistry (16.08.2022)
Published in Frontiers in chemistry (16.08.2022)
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Journal Article
Affibody-DyLight conjugates for in vivo assessment of HER2 expression by near-infrared optical imaging
Zielinski, Rafal, Hassan, Moinuddin, Lyakhov, Ilya, Needle, Danielle, Chernomordik, Victor, Garcia-Glaessner, Alejandra, Ardeshirpour, Yasaman, Capala, Jacek, Gandjbakhche, Amir
Published in PloS one (20.07.2012)
Published in PloS one (20.07.2012)
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Journal Article
Sequence of the Escherichia coli O121 O-Antigen Gene Cluster and Detection of Enterohemorrhagic E. coli O121 by PCR Amplification of the wzx and wzy Genes
Fratamico, Pina M, Briggs, Connie E, Needle, Danielle, Chen, Chin-Yi, DebRoy, Chitrita
Published in Journal of Clinical Microbiology (01.07.2003)
Published in Journal of Clinical Microbiology (01.07.2003)
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Journal Article
Self-inhibited State of Venezuelan Equine Encephalitis Virus (VEEV) nsP2 Cysteine Protease: A Crystallographic and Molecular Dynamics Analysis
Hoffka, Gyula, Lountos, George T., Needle, Danielle, Wlodawer, Alexander, Waugh, David S., Tőzsér, József, Mótyán, János András
Published in Journal of molecular biology (15.03.2023)
Published in Journal of molecular biology (15.03.2023)
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Journal Article
The molecular mechanism of dsRNA processing by a bacterial Dicer
Jin, Lan, Song, He, Tropea, Joseph E, Needle, Danielle, Waugh, David S, Gu, Shuo, Ji, Xinhua
Published in Nucleic acids research (21.05.2019)
Published in Nucleic acids research (21.05.2019)
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Journal Article
Hyperthermia-triggered intracellular delivery of anticancer agent to HER2(+) cells by HER2-specific affibody (ZHER2-GS-Cys)-conjugated thermosensitive liposomes (HER2(+) affisomes)
Smith, Brandon, Lyakhov, Ilya, Loomis, Kristin, Needle, Danielle, Baxa, Ulrich, Yavlovich, Amichai, Capala, Jacek, Blumenthal, Robert, Puri, Anu
Published in Journal of controlled release (30.07.2011)
Published in Journal of controlled release (30.07.2011)
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Journal Article
Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites
Zhao, Xue Zhi, Kiselev, Evgeny, Lountos, George T, Wang, Wenjie, Tropea, Joseph E, Needle, Danielle, Hilimire, Thomas A, Schneekloth, John S, Waugh, David S, Pommier, Yves, Burke, Terrence R
Published in Chemical science (Cambridge) (28.01.2021)
Published in Chemical science (Cambridge) (28.01.2021)
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Journal Article
Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification
Zhao, Xue Zhi, Wang, Wenjie, Lountos, George T, Kiselev, Evgeny, Tropea, Joseph E, Needle, Danielle, Pommier, Yves, Burke, Terrence R
Published in RSC chemical biology (10.05.2023)
Published in RSC chemical biology (10.05.2023)
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Journal Article
Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9
Hewitt, William M., Lountos, George T., Zlotkowski, Katherine, Dahlhauser, Samuel D., Saunders, Lindsey B., Needle, Danielle, Tropea, Joseph E., Zhan, Chendi, Wei, Guanghong, Ma, Buyong, Nussinov, Ruth, Waugh, David S., Schneekloth Jr, John S.
Published in Angewandte Chemie (International ed.) (04.05.2016)
Published in Angewandte Chemie (International ed.) (04.05.2016)
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Journal Article
Identification of lead compounds for inhibitor design against tyrosyl DNA phosphodiesterase I by crystallographic fragment screening
Lountos, George T., Zhao, Xue Zhi, Kiselev, Evgeny, Tropea, Joseph E., Needle, Danielle, Burke, Terrence R., Pommier, Yves, Waugh, David S.
Published in Acta crystallographica. Section A, Foundations and advances (26.05.2017)
Published in Acta crystallographica. Section A, Foundations and advances (26.05.2017)
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Journal Article
Insights Into the Allosteric Inhibition of Ubc9, the SUMO E2 Enzyme
Hewitt, William M., Lountos, George T., Zlotkowski, Katherine, Dahlhauser, Samuel D., Saunders, Lindsey B., Needle, Danielle, Tropea, Joseph E., Zhan, Chendi, Wei, Guanghong, Ma, Buyong, Nussinov, Ruth, Waugh, David S., Schneekloth, John S.
Published in Angewandte Chemie International Edition (01.04.2016)
Published in Angewandte Chemie International Edition (01.04.2016)
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Journal Article
Structural enzymology and inhibition of the bi‐functional folate pathway enzyme HPPK–DHPS from the biowarfare agent Francisella tularensis
Shaw, Gary X, Li, Yue, Shi, Genbin, Wu, Yan, Cherry, Scott, Needle, Danielle, Zhang, Di, Tropea, Joseph E, Waugh, David S, Yan, Honggao, Ji, Xinhua
Published in The FEBS journal (01.09.2014)
Published in The FEBS journal (01.09.2014)
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Journal Article
Structural enzymology and inhibition of the bi‐functional folate pathway enzyme HPPK – DHPS from the biowarfare agent F rancisella tularensis
Shaw, Gary X., Li, Yue, Shi, Genbin, Wu, Yan, Cherry, Scott, Needle, Danielle, Zhang, Di, Tropea, Joseph E., Waugh, David S., Yan, Honggao, Ji, Xinhua
Published in The FEBS journal (01.09.2014)
Published in The FEBS journal (01.09.2014)
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Journal Article
Structural enzymology and inhibition of the bifunctional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis
Shaw, Gary X., Li, Yue, Shi, Genbin, Wu, Yan, Cherry, Scott, Needle, Danielle, Zhang, Di, Tropea, Joseph E., Waugh, David S., Yan, Honggao, Ji, Xinhua
Published in The FEBS journal (23.07.2014)
Published in The FEBS journal (23.07.2014)
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Journal Article
A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways
Zlotkowski, Katherine, Hewitt, William M., Sinniah, Ranu S., Tropea, Joseph E., Needle, Danielle, Lountos, George T., Barchi, Joseph J., Waugh, David S., Schneekloth, John S.
Published in SLAS discovery (01.07.2017)
Published in SLAS discovery (01.07.2017)
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