Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)
Naud, Sébastien, Westwood, Isaac M, Faisal, Amir, Sheldrake, Peter, Bavetsias, Vassilios, Atrash, Butrus, Cheung, Kwai-Ming J, Liu, Manjuan, Hayes, Angela, Schmitt, Jessica, Wood, Amy, Choi, Vanessa, Boxall, Kathy, Mak, Grace, Gurden, Mark, Valenti, Melanie, de Haven Brandon, Alexis, Henley, Alan, Baker, Ross, McAndrew, Craig, Matijssen, Berry, Burke, Rosemary, Hoelder, Swen, Eccles, Suzanne A, Raynaud, Florence I, Linardopoulos, Spiros, van Montfort, Rob L. M, Blagg, Julian
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
Anderhub, Simon J, Mak, Grace Wing-Yan, Gurden, Mark D, Faisal, Amir, Drosopoulos, Konstantinos, Walsh, Katie, Woodward, Hannah L, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Theofani, Efthymia, Filosto, Simone, Saville, Harry, Burke, Rosemary, van Montfort, Rob L M, Raynaud, Florence I, Blagg, Julian, Hoelder, Swen, Eccles, Suzanne A, Linardopoulos, Spiros
Published in Molecular cancer therapeutics (01.10.2019)
Published in Molecular cancer therapeutics (01.10.2019)
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Journal Article
Rapid Discovery of Pyrido[3,4‑d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach
Innocenti, Paolo, Woodward, Hannah L, Solanki, Savade, Naud, Sébastien, Westwood, Isaac M, Cronin, Nora, Hayes, Angela, Roberts, Jennie, Henley, Alan T, Baker, Ross, Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Matijssen, Berry, Burke, Rosemary, van Montfort, Rob L. M, Raynaud, Florence I, Eccles, Suzanne A, Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen
Published in Journal of medicinal chemistry (28.04.2016)
Published in Journal of medicinal chemistry (28.04.2016)
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Journal Article
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy
Faisal, Amir, Mak, Grace W Y, Gurden, Mark D, Xavier, Cristina P R, Anderhub, Simon J, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Box, Gary, Valenti, Melanie R, De Haven Brandon, Alexis K, O'Fee, Lisa, Schmitt, Jessica, Woodward, Hannah L, Burke, Rosemary, vanMontfort, Rob L M, Blagg, Julian, Raynaud, Florence I, Eccles, Suzanne A, Hoelder, Swen, Linardopoulos, Spiros
Published in British journal of cancer (25.04.2017)
Published in British journal of cancer (25.04.2017)
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Journal Article
Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Gurden, Mark D, Westwood, Isaac M, Faisal, Amir, Naud, Sébastien, Cheung, Kwai-Ming J, McAndrew, Craig, Wood, Amy, Schmitt, Jessica, Boxall, Kathy, Mak, Grace, Workman, Paul, Burke, Rosemary, Hoelder, Swen, Blagg, Julian, Van Montfort, Rob L M, Linardopoulos, Spiros
Published in Cancer research (Chicago, Ill.) (15.08.2015)
Published in Cancer research (Chicago, Ill.) (15.08.2015)
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Journal Article
Synthesis of Polyhydroxylated Pyrano-Pyrrole Derivatives from Carbohydrate Precursors
Naud, Sébastien, Pipelier, Muriel, Viault, Guillaume, Adjou, Ané, Huet, François, Legoupy, Stéphanie, Aubertin, Anne-Marie, Evain, Michel, Dubreuil, Didier
Published in European Journal of Organic Chemistry (01.07.2007)
Published in European Journal of Organic Chemistry (01.07.2007)
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Book Review
Journal Article
Synthesis of novel polyhydroxylated tetrahydropyranopyrroles
Naud, Sebastien, Pipelier, Muriel, Chaumette, Christophe, Viault, Guillaume, Huet, Francois, Legoupy, Stephanie, Dubreuil, Didier
Published in Synlett (15.02.2007)
Published in Synlett (15.02.2007)
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Journal Article
Conformational preferences of oxy-substituents in butenolide-tetrahydropyran spiroacetals and butenolide-piperidine spiro-N,O-acetals
Naud, Sebastien, Macnaughton, Sarah J., Dyson, Bryony S., Woollaston, Daniel J., Dallimore, Jonathan W. P., Robertson, Jeremy
Published in Organic & biomolecular chemistry (07.05.2012)
Published in Organic & biomolecular chemistry (07.05.2012)
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Journal Article
옥세타닐페녹시퀴놀린 및 유사체
LAMPRECHT SYBILLE, DUFOUR JEREMY, MEISSNER RUTH, NAUD SEBASTIEN, THOMAS VINCENT, DESBORDES PHILIPPE
Year of Publication 30.06.2021
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Year of Publication 30.06.2021
Patent
헤테로아릴아미노퀴놀린 및 유사체
GOURGUES MATHIEU, CRISTAU PIERRE, DUFOUR JEREMY, LOQUE DOMINIQUE, NAUD SEBASTIEN, THOMAS VINCENT, DESBORDES PHILIPPE
Year of Publication 29.06.2021
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Year of Publication 29.06.2021
Patent
Abstract 4036: Induction of detrimental aneuploidy in basal breast cancer cells treated by MPS1 inhibitors in combination with paclitaxel
Anderhub, Simon J., Mak, Grace WY, Faisal, Amir, Walsh, Katie, Gurden, Mark, Day, Liz, Innocenti, Paolo, Woodward, Hannah L., Westwood, Isaac M., Cheung, Kwai-Ming J., Naud, Sebastien, Hayes, Angela, Box, Gary, Brandon, Alexis de Haven, Valenti, Melanie R., O’Fee, Lisa, Saville, Harry, Burke, Rosemary, Montfort, Rob LM van, Raynaud, Florence I., Eccles, Suzanne A., Blagg, Julian, Hoelder, Swen, Linardopoulos, Spiros
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
피리딜페닐아미노퀴놀린 및 유사체
GOURGUES MATHIEU, CRISTAU PIERRE, LAMPRECHT SYBILLE, DUFOUR JEREMY, LOQUE DOMINIQUE, MEISSNER RUTH, NAUD SEBASTIEN, THOMAS VINCENT, DESBORDES PHILIPPE
Year of Publication 01.07.2021
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Year of Publication 01.07.2021
Patent
Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2
Hilton, Stephen, Naud, Sebastien, Caldwell, John J., Boxall, Kathy, Burns, Samantha, Anderson, Victoria E., Antoni, Laurent, Allen, Charlotte E., Pearl, Laurence H., Oliver, Antony W., Wynne Aherne, G., Garrett, Michelle D., Collins, Ian
Published in Bioorganic & medicinal chemistry (15.01.2010)
Published in Bioorganic & medicinal chemistry (15.01.2010)
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Journal Article
헤테로아릴페닐아미노퀴놀린 및 유사체
GOURGUES MATHIEU, LEMPEREUR VIRGINIE, CRISTAU PIERRE, RINOLFI PHILIPPE, LOQUE DOMINIQUE, DUBOST CHRISTOPHE, DESBORDES PHILIPPE, VILLALBA FRANCOIS, TOQUIN VALERIE, DUFOUR JEREMY, WACHENDORFF NEUMANN ULRIKE, NAUD SEBASTIEN, MILLET ANTHONY
Year of Publication 24.12.2019
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Year of Publication 24.12.2019
Patent
신규 5-치환된 이미다졸릴메틸 유도체
BERNIER DAVID, GENIX PIERRE, COQUERON PIERRE YVES, MILLER RICARDA, GOERTZ ANDREAS, KENNEL PHILIPPE, NICOLAS LIONEL, WITTROCK SVEN, WACHENDORFF NEUMANN ULRIKE, NAUD SEBASTIEN, MEISSNER RUTH, BRUNET STEPHANE, DAHMEN PETER
Year of Publication 22.05.2019
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Year of Publication 22.05.2019
Patent
살진균제로서의 5-치환된 이미다졸릴메틸옥시란 유도체
BERNIER DAVID, MILLER RICARDA, GOERTZ ANDREAS, KENNEL PHILIPPE, GENIX PIERRE, COQUERON PIERRE YVES, WITTROCK SVEN, WACHENDORFF NEUMANN ULRIKE, NAUD SEBASTIEN, MEISSNER RUTH, BRUNET STEPHANE
Year of Publication 21.05.2019
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Year of Publication 21.05.2019
Patent
살진균제로서의 5-치환된 이미다졸릴메틸디옥솔란 유도체
BERNIER DAVID, MILLER RICARDA, GOERTZ ANDREAS, KENNEL PHILIPPE, GENIX PIERRE, COQUERON PIERRE YVES, WITTROCK SVEN, WACHENDORFF NEUMANN ULRIKE, NAUD SEBASTIEN, MEISSNER RUTH, BRUNET STEPHANE
Year of Publication 17.05.2019
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Year of Publication 17.05.2019
Patent
트리아졸 유도체, 그의 중간체 및 살진균제로서의 그의 용도
BERNIER DAVID, GENIX PIERRE, COQUERON PIERRE YVES, SUDAU ALEXANDER, MILLER RICARDA, KENNEL PHILIPPE, WITTROCK SVEN, WACHENDORFF NEUMANN ULRIKE, MEISSNER RUTH, NAUD SEBASTIEN, GEIST JULIE, BRUNET STEPHANE, HOFFMANN SEBASTIAN, VORS JEAN PIERRE, DAHMEN PETER
Year of Publication 11.04.2018
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Year of Publication 11.04.2018
Patent