Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles
Court, John J, Poisson, Carl, Ardzinski, Andrzej, Bilimoria, Darius, Chan, Laval, Chandupatla, Kishan, Chauret, Nathalie, Collier, Philip N, Das, Sanjoy Kumar, Denis, Francois, Dorsch, Warren, Iyer, Ganesh, Lauffer, David, L’Heureux, Lucille, Li, Pan, Luisi, Brian S, Mani, Nagraj, Nanthakumar, Suganthi, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S, Tang, Qing, Waal, Nathan D, Yannopoulos, Constantin G, Green, Jeremy
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Journal Article
Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates
Li, Pan, Dorsch, Warren, Lauffer, David J., Bilimoria, Darius, Chauret, Nathalie, Court, John J., Das, Sanjoy Kumar, Denis, Francois, Mani, Nagraj, Nanthakumar, Suganthini, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S., Stearns, Ralph, Tang, Qing, Waal, Nathan D., Green, Jeremy
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Integrating Fragment Assembly and Biophysical Methods in the Chemical Advancement of Small-Molecule Antagonists of IL-2: An Approach for Inhibiting Protein−Protein Interactions
Raimundo, Brian C, Oslob, Johan D, Braisted, Andrew C, Hyde, Jennifer, McDowell, Robert S, Randal, Mike, Waal, Nathan D, Wilkinson, Jennifer, Yu, Chul H, Arkin, Michelle R
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Journal Article
Tethering identifies fragment that yields potent inhibitors of human caspase-1
Fahr, Bruce T., O’Brien, Tom, Pham, Phuongly, Waal, Nathan D., Baskaran, Subramanian, Raimundo, Brian C., Lam, Joni W., Sopko, Michelle M., Purkey, Hans E., Romanowski, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
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PTERIDINONE COMPOUNDS AND USES THEREOF
GU WENXIN, MARINA PENNEY, LEDFORD BRIAN, MALTAIS FRANCOIS, DAVID DEININGER, NATHAN D WAAL, MARK WILLEM LEDEBOER, LI PAN, DENG HONGBO, LAUFFER DAVID J, GUY BEMIS, RUSSELL R HOOVER, MAC ARTHUR JOHNSON JR, DARIN TAKEMOTO, WANG TIANSHENG, MICHAEL BOYD, WARREN DORSCH
Year of Publication 22.08.2023
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Year of Publication 22.08.2023
Patent
ANTIPROLIFERATIVE COMPOUNDS AND USES THEREOF
STEVEN RONKIN, TANG QING, CLARKE MICHAEL, MARINA PENNEY, NATHAN D WAAL, LI PAN, DENG HONGBO, DONG HUIJUN, PHILIP COLLIER, LAUFFER DAVID J, GUY BEMIS, RUSSELL R HOOVER, HENRY YU, MAC ARTHUR JOHNSON JR, SHASHANK KUKAMI, DARIN TAKEMOTO, WANG TIANSHENG, MICHAEL BOYD, KISHAN CHANDUPATLA, WARREN DORSCH
Year of Publication 21.07.2023
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Year of Publication 21.07.2023
Patent
Identification of nonpeptidic small-molecule inhibitors of interleukin-2
Waal, Nathan D., Yang, Wenjin, Oslob, Johan D., Arkin, Michelle R., Hyde, Jennifer, Lu, Wanli, McDowell, Robert S., Yu, Chul H., Raimundo, Brian C.
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Journal Article
DNA-PK INHIBITORS
JOHN PATRICK MAXWELL, KEVIN MICHAEL COTTRELL, JOSEPH M KENNEDY, NATHAN D WAAL, MARK WILLEM LEDEBOER, LI PAN, DENG HONGBO, SIMON GIROUX, XU JINWANG, LAUFFER DAVID J, MARK A MORRIS, ALBERT CHARLES PIERCE, GREEN JEREMY, GAO HUAI, DUFFY JOHN P, CHARIFSON PAUL S, KATRINA LEE JACKSON
Year of Publication 05.09.2019
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Year of Publication 05.09.2019
Patent
DNA-PK INHIBITOR
TANG QING, RONKIN STEVEN M, GU WENXIN, JOHN PATRICK MAXWELL, NATHAN D WAAL, LI PAN, SIMON GIROUX, DENG HONGBO, XU JINWANG, LAUFFER DAVID J, ALBERT CHARLES PIERCE, MARK A MORRIS, COURT JOHN J, CHARIFSON PAUL S, KEVIN M COTTRELL, KATRINA LEE JACKSON
Year of Publication 30.08.2018
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Year of Publication 30.08.2018
Patent
Structural analysis of caspase-1 inhibitors derived from Tethering
Fahr, Bruce T., Sopko, Michelle M., Lam, Joni W., O'Brien, Tom, Waal, Nathan D., Pham, Phuongly, Purkey, Hans E., Raimundo, Brian C., Romanowski, Michael J.
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.05.2005)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.05.2005)
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Journal Article
DNA-PK INHIBITORS
JOHN PATRICK MAXWELL, KEVIN MICHAEL COTTRELL, JOSEPH M KENNEDY, NATHAN D WAAL, MARK WILLEM LEDEBOER, LI PAN, DENG HONGBO, SIMON GIROUX, XU JINWANG, LAUFFER DAVID J, MARK A MORRIS, ALBERT CHARLES PIERCE, GREEN JEREMY, GAO HUAI, DUFFY JOHN P, CHARIFSON PAUL S, KATRINA LEE JACKSON
Year of Publication 21.09.2017
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Year of Publication 21.09.2017
Patent
PTERIDINONE COMPOUNDS AND USES THEREOF
Takemoto, Darin, Li, Pan, Gu, Wenxin, Bemis, Guy, Dorsch, Warren, Boyd, Michael, Deng, Hongbo, Wang, Tiansheng, Ledeboer, Mark Willem, Penney, Marina, Ledford, Brian, LAUFFER, David, Maltais, Francois, Deininger, David, Waal, Nathan D, Hoover, Russell R, Johnson, JR., Mac Arthur
Year of Publication 05.10.2023
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Year of Publication 05.10.2023
Patent
ANTIPROLIFERATION COMPOUNDS AND USES THEREOF
WANG, Tiansheng, LAUFFER, David J, JOHNSON, Mac, Arthur, JR, WAAL, Nathan, D, YU, Henry, HOOVER, Russell, R, KULKARNI, Shashank, COLLIER, Philip, BEMIS, Guy, TAKEMOTO, Darin, DONG, Huijun, CHANDUPATLA, Kishan, CLARK, Michael, PENNEY, Marina, LI, Pan, DENG, Hongbo, RONKIN, Steven, DORSCH, Warren, BOYD, Michael, TANG, Qing
Year of Publication 05.06.2024
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Year of Publication 05.06.2024
Patent
ANTIPROLIFERATION COMPOUNDS AND USES THEREOF
HUIJUN DONG, STEVEN RONKIN, TIANSHENG WANG, DAVID J LAUFFER, MICHAEL CLARK, HONGBO DENG, MARINA PENNEY, Pan LI, NATHAN D WAAL, Qing TANG, PHILIP COLLIER, KULKARNI, SHASHANK, GUY BEMIS, RUSSELL R HOOVER, HENRY YU, MAC ARTHUR JOHNSON JR, DARIN TAKEMOTO, MICHAEL BOYD, KISHAN CHANDUPATLA, WARREN DORSCH
Year of Publication 31.01.2024
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Year of Publication 31.01.2024
Patent
Pteridinone compounds and uses thereof
Takemoto, Darin, Li, Pan, Gu, Wenxin, Bemis, Guy, Dorsch, Warren, Boyd, Michael, Deng, Hongbo, Johnson, Jr., Mac Arthur, Wang, Tiansheng, Ledeboer, Mark Willem, Penney, Marina, Lauffer, David, Ledford, Brian, Maltais, Francois, Deininger, David, Waal, Nathan D, Hoover, Russell R
Year of Publication 07.02.2023
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Year of Publication 07.02.2023
Patent
DNA-PK inhibitors
Jackson, Katrina Lee, Maxwell, John Patrick, Li, Pan, Gu, Wenxin, Ronkin, Steven M, Deng, Hongbo, Court, John J, Morris, Mark A, Charifson, Paul S, Giroux, Simon, Xu, Jinwang, Pierce, Albert Charles, Cottrell, Kevin Michael, Tang, Qing, Lauffer, David J, Waal, Nathan D
Year of Publication 14.11.2023
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Year of Publication 14.11.2023
Patent
PTERIDINONE COMPOUNDS AND USES THEREOF
DEININGER, David, WAAL, Nathan, D, LEDFORD, Brian, LAUFFER, David, J, HOOVER, Russell, R, BEMIS, Guy, GU, Wenxin, LEDEBOER, Mark, Willem, TAKEMOTO, Darin, WENG, Tiansheng, PENNEY, Marina, JOHNSON, Mac, Arthur, Jr, LI, Pan, DENG, Hongbo, DORSCH, Warren, BOYD, Michael, MALTAIS, Francois
Year of Publication 25.10.2023
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Year of Publication 25.10.2023
Patent
SUBSTITUTED QUINOXALINE DNA-PK INHIBITORS
Jackson, Katrina Lee, Maxwell, John Patrick, Li, Pan, Gu, Wenxin, Ronkin, Steven M, Deng, Hongbo, Court, John J, Morris, Mark A, Charifson, Paul S, Giroux, Simon, Xu, Jinwang, Pierce, Albert Charles, Cottrell, Kevin Michael, Tang, Qing, Lauffer, David J, Waal, Nathan D
Year of Publication 07.09.2023
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Year of Publication 07.09.2023
Patent
DNA-PK INHIBITORS
LAUFFER, David J, COURT, John J, GU, Wenxin, JACKSON, Katrina Lee, MAXWELL, John Patrick, RONKIN, Steven M, XU, Jinwang, CHARIFSON, Paul S, MORRIS, Mark A, COTTRELL, Kevin M, LI, Pan, DENG, Hongbo, PIERCE, Albert Charles, GIROUX, Simon, WAAL, Nathan D, TANG, Qing
Year of Publication 09.08.2023
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Year of Publication 09.08.2023
Patent
DNA-PK INHIBITORS
LAUFFER, David J, COURT, John J, GU, Wenxin, JACKSON, Katrina Lee, MAXWELL, John Patrick, RONKIN, Steven M, XU, Jinwang, CHARIFSON, Paul S, MORRIS, Mark A, COTTRELL, Kevin M, LI, Pan, DENG, Hongbo, PIERCE, Albert Charles, GIROUX, Simon, WAAL, Nathan D, TANG, Qing
Year of Publication 09.08.2023
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Year of Publication 09.08.2023
Patent