Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19
Painter, George R, Natchus, Michael G, Cohen, Oren, Holman, Wendy, Painter, Wendy P
Published in Current opinion in virology (01.10.2021)
Published in Current opinion in virology (01.10.2021)
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SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
Wahl, Angela, Gralinski, Lisa E., Johnson, Claire E., Yao, Wenbo, Kovarova, Martina, Dinnon, Kenneth H., Liu, Hongwei, Madden, Victoria J., Krzystek, Halina M., De, Chandrav, White, Kristen K., Gully, Kendra, Schäfer, Alexandra, Zaman, Tanzila, Leist, Sarah R., Grant, Paul O., Bluemling, Gregory R., Kolykhalov, Alexander A., Natchus, Michael G., Askin, Frederic B., Painter, George, Browne, Edward P., Jones, Corbin D., Pickles, Raymond J., Baric, Ralph S., Garcia, J. Victor
Published in Nature (London) (18.03.2021)
Published in Nature (London) (18.03.2021)
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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
Sheahan, Timothy P, Sims, Amy C, Zhou, Shuntai, Graham, Rachel L, Pruijssers, Andrea J, Agostini, Maria L, Leist, Sarah R, Schäfer, Alexandra, Dinnon, 3rd, Kenneth H, Stevens, Laura J, Chappell, James D, Lu, Xiaotao, Hughes, Tia M, George, Amelia S, Hill, Collin S, Montgomery, Stephanie A, Brown, Ariane J, Bluemling, Gregory R, Natchus, Michael G, Saindane, Manohar, Kolykhalov, Alexander A, Painter, George, Harcourt, Jennifer, Tamin, Azaibi, Thornburg, Natalie J, Swanstrom, Ronald, Denison, Mark R, Baric, Ralph S
Published in Science Translational Medicine (29.04.2020)
Published in Science Translational Medicine (29.04.2020)
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Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses
Yoon, Jeong-Joong, Toots, Mart, Lee, Sujin, Lee, Myung-Eun, Ludeke, Barbara, Luczo, Jasmina M, Ganti, Ketaki, Cox, Robert M, Sticher, Zachary M, Edpuganti, Vindya, Mitchell, Deborah G, Lockwood, Mark A, Kolykhalov, Alexander A, Greninger, Alexander L, Moore, Martin L, Painter, George R, Lowen, Anice C, Tompkins, Stephen M, Fearns, Rachel, Natchus, Michael G, Plemper, Richard K
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Published in Antimicrobial agents and chemotherapy (01.08.2018)
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The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection
Painter, George R., Bowen, Richard A., Bluemling, Gregory R., DeBergh, John, Edpuganti, Vindhya, Gruddanti, Prabhakar R., Guthrie, David B., Hager, Michael, Kuiper, Damien L., Lockwood, Mark A., Mitchell, Deborah G., Natchus, Michael G., Sticher, Zachary M., Kolykhalov, Alexander A.
Published in Antiviral research (01.11.2019)
Published in Antiviral research (01.11.2019)
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SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model
Lieber, Carolin M., Cox, Robert M., Sourimant, Julien, Wolf, Josef D., Juergens, Kate, Phung, Quynh, Saindane, Manohar T., Smith, Meghan K., Sticher, Zachary M., Kalykhalov, Alexander A., Natchus, Michael G., Painter, George R., Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.
Published in Nature communications (29.07.2022)
Published in Nature communications (29.07.2022)
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Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models
Cox, Robert M., Lieber, Carolin M., Wolf, Josef D., Karimi, Amirhossein, Lieberman, Nicole A. P., Sticher, Zachary M., Roychoudhury, Pavitra, Andrews, Meghan K., Krueger, Rebecca E., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A., Greninger, Alexander L., Plemper, Richard K.
Published in Nature communications (07.08.2023)
Published in Nature communications (07.08.2023)
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Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo
Lieber, Carolin M, Kang, Hae-Ji, Aggarwal, Megha, Lieberman, Nicole A, Sobolik, Elizabeth B, Yoon, Jeong-Joong, Natchus, Michael G, Cox, Robert M, Greninger, Alexander L, Plemper, Richard K
Published in PLoS pathogens (01.02.2024)
Published in PLoS pathogens (01.02.2024)
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Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets
Cox, Robert M., Wolf, Josef D., Lieberman, Nicole A., Lieber, Carolin M., Kang, Hae-Ji, Sticher, Zachary M., Yoon, Jeong-Joong, Andrews, Meghan K., Govindarajan, Mugunthan, Krueger, Rebecca E., Sobolik, Elizabeth B., Natchus, Michael G., Gewirtz, Andrew T., deSwart, Rik L., Kolykhalov, Alexander A., Hekmatyar, Khan, Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.
Published in Nature communications (08.02.2024)
Published in Nature communications (08.02.2024)
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4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses
Lieber, Carolin M, Aggarwal, Megha, Yoon, Jeong-Joong, Cox, Robert M, Kang, Hae-Ji, Sourimant, Julien, Toots, Mart, Johnson, Scott K, Jones, Cheryl A, Sticher, Zachary M, Kolykhalov, Alexander A, Saindane, Manohar T, Tompkins, Stephen M, Planz, Oliver, Painter, George R, Natchus, Michael G, Sakamoto, Kaori, Plemper, Richard K
Published in PLoS pathogens (17.04.2023)
Published in PLoS pathogens (17.04.2023)
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Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
Wittwer, Kevin, Anderson, Danielle E., Pfeffermann, Kristin, Cox, Robert M., Wolf, Josef D., Santibanez, Sabine, Mankertz, Annette, Plesker, Roland, Sticher, Zachary M., Kolkykhalov, Alexander A., Natchus, Michael G., Pfaller, Christian K., Plemper, Richard K., von Messling, Veronika
Published in Nature communications (02.09.2021)
Published in Nature communications (02.09.2021)
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4'-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo
Yin, Peiqi, May, Nicholas A, Lello, Laura Sandra, Fayed, Atef, Parks, M Guston, Drobish, Adam M, Wang, Sainan, Andrews, Meghan, Sticher, Zachary, Kolykhalov, Alexander A, Natchus, Michael G, Painter, George R, Merits, Andres, Kielian, Margaret, Morrison, Thomas E
Published in mBio (12.06.2024)
Published in mBio (12.06.2024)
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Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model
Toots, Mart, Yoon, Jeong-Joong, Hart, Michael, Natchus, Michael G., Painter, George R., Plemper, Richard K.
Published in Translational research : the journal of laboratory and clinical medicine (01.04.2020)
Published in Translational research : the journal of laboratory and clinical medicine (01.04.2020)
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Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.
Published in Journal of virology (15.12.2019)
Published in Journal of virology (15.12.2019)
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Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
Agostini, Maria L, Pruijssers, Andrea J, Chappell, James D, Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L, Bluemling, Gregory R, Lockwood, Mark A, Sheahan, Timothy P, Sims, Amy C, Natchus, Michael G, Saindane, Manohar, Kolykhalov, Alexander A, Painter, George R, Baric, Ralph S, Denison, Mark R
Published in Journal of virology (01.12.2019)
Published in Journal of virology (01.12.2019)
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Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia
Toots, Mart, Yoon, Jeong-Joong, Cox, Robert M, Hart, Michael, Sticher, Zachary M, Makhsous, Negar, Plesker, Roland, Barrena, Alec H, Reddy, Prabhakar G, Mitchell, Deborah G, Shean, Ryan C, Bluemling, Gregory R, Kolykhalov, Alexander A, Greninger, Alexander L, Natchus, Michael G, Painter, George R, Plemper, Richard K
Published in Science translational medicine (23.10.2019)
Published in Science translational medicine (23.10.2019)
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β-d- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome
Urakova, Nadya, Kuznetsova, Valeriya, Crossman, David K, Sokratian, Arpine, Guthrie, David B, Kolykhalov, Alexander A, Lockwood, Mark A, Natchus, Michael G, Crowley, Michael R, Painter, George R, Frolova, Elena I, Frolov, Ilya
Published in Journal of virology (01.02.2018)
Published in Journal of virology (01.02.2018)
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4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication
Sourimant, Julien, Lieber, Carolin M, Aggarwal, Megha, Cox, Robert M, Wolf, Josef D, Yoon, Jeong-Joong, Toots, Mart, Ye, Chengin, Sticher, Zachary, Kolykhalov, Alexander A, Martinez-Sobrido, Luis, Bluemling, Gregory R, Natchus, Michael G, Painter, George R, Plemper, Richard K
Published in Science (American Association for the Advancement of Science) (14.01.2022)
Published in Science (American Association for the Advancement of Science) (14.01.2022)
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Efficacy of late-onset antiviral treatment in immunocompromised hosts with persistent SARS-CoV-2 infection
Lieber, Carolin M, Kang, Hae-Ji, Sobolik, Elizabeth B, Sticher, Zachary M, Ngo, Vu L, Gewirtz, Andrew T, Kolykhalov, Alexander A, Natchus, Michael G, Greninger, Alexander L, Suthar, Mehul S, Plemper, Richard K
Published in Journal of virology (17.09.2024)
Published in Journal of virology (17.09.2024)
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