Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small Molecule Inhibitors Bound to a Novel Allosteric Site
Di Marco, Stefania, Volpari, Cinzia, Tomei, Licia, Altamura, Sergio, Harper, Steven, Narjes, Frank, Koch, Uwe, Rowley, Michael, De Francesco, Raffaele, Migliaccio, Giovanni, Carfí, Andrea
Published in The Journal of biological chemistry (19.08.2005)
Published in The Journal of biological chemistry (19.08.2005)
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Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)
Edfeldt, Fredrik, Evenäs, Johan, Lepistö, Matti, Ward, Alison, Petersen, Jens, Wissler, Lisa, Rohman, Mattias, Sivars, Ulf, Svensson, Karin, Perry, Matthew, Feierberg, Isabella, Zhou, Xiao-Hong, Hansson, Thomas, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (15.06.2015)
Published in Bioorganic & medicinal chemistry letters (15.06.2015)
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Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase
Stansfield, Ian, Ercolani, Caterina, Mackay, Angela, Conte, Immacolata, Pompei, Marco, Koch, Uwe, Gennari, Nadia, Giuliano, Claudio, Rowley, Michael, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Mechanism of Action and Antiviral Activity of Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase
Tomei, Licia, Altamura, Sergio, Bartholomew, Linda, Biroccio, Antonino, Ceccacci, Alessandra, Pacini, Laura, Narjes, Frank, Gennari, Nadia, Bisbocci, Monica, Incitti, Ilario, Orsatti, Laura, Harper, Steven, Stansfield, Ian, Rowley, Michael, De Francesco, Raffaele, Migliaccio, Giovanni
Published in Journal of Virology (01.12.2003)
Published in Journal of Virology (01.12.2003)
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Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-N-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase
Harper, Steven, Avolio, Salvatore, Pacini, Barbara, Di Filippo, Marcello, Altamura, Sergio, Tomei, Licia, Paonessa, Giacomo, Di Marco, Carfi, Andrea, Giuliano, Claudio, Padron, Julio, Bonelli, Fabio, Migliaccio, Giovanni, De Francesco, Raffaele, Laufer, Ralph, Rowley, Michael, Narjes, Frank
Published in Journal of medicinal chemistry (14.07.2005)
Published in Journal of medicinal chemistry (14.07.2005)
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In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor
Trozzi, Caterina, Bartholomew, Linda, Ceccacci, Alessandra, Biasiol, Gabriella, Pacini, Laura, Altamura, Sergio, Narjes, Frank, Muraglia, Ester, Paonessa, Giacomo, Koch, Uwe, De Francesco, Raffaele, Steinkuhler, Christian, Migliaccio, Giovanni
Published in Journal of Virology (01.03.2003)
Published in Journal of Virology (01.03.2003)
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Development of carboxylic acid replacements in indole- N-acetamide inhibitors of hepatitis C virus NS5B polymerase
Stansfield, Ian, Pompei, Marco, Conte, Immacolata, Ercolani, Caterina, Migliaccio, Giovanni, Jairaj, Mark, Giuliano, Claudio, Rowley, Michael, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
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Identification of thieno[3,2- b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase
Ontoria, Jesus M., Martìn Hernando, Jose I., Malancona, Savina, Attenni, Barbara, Stansfield, Ian, Conte, Immacolata, Ercolani, Caterina, Habermann, Jörg, Ponzi, Simona, Di Filippo, Marcello, Koch, Uwe, Rowley, Michael, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
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Improved modular synthesis of thieno[3,2- b]pyrroles and thieno[2,3- b]pyrroles
Malancona, Savina, Hernando, Josè I. Martin, Attenni, Barbara, Ontoria, Jesus M., Narjes, Frank
Published in Tetrahedron letters (08.04.2009)
Published in Tetrahedron letters (08.04.2009)
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Development of a Scalable Chiral Synthesis of MK-3281, an Inhibitor of the Hepatitis C Virus NS5B Polymerase
Colarusso, Stefania, Conte, Immacolata, Di Filippo, Marcello, Ercolani, Caterina, Mackay, Angela C., Palumbi, Maria Cecilia, Ferreira, Maria del Rosario Rico, Stansfield, Ian, Zaramella, Simone, Narjes, Frank, Habermann, Joerg
Published in Synlett (01.07.2011)
Published in Synlett (01.07.2011)
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Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase
Martin Hernando, Jose Ignacio, Ontoria, Jesus Maria, Malancona, Savina, Attenni, Barbara, Fiore, Fabrizio, Bonelli, Fabio, Koch, Uwe, Di Marco, Stefania, Colarusso, Stefania, Ponzi, Simona, Gennari, Nadia, Vignetti, Sue Ellen, del Rosario Rico Ferreira, Maria, Habermann, Jörg, Rowley, Michael, Narjes, Frank
Published in ChemMedChem (05.10.2009)
Published in ChemMedChem (05.10.2009)
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Hepatitis C Virus Serine Protease Inhibitors: Current Progress and Future Challenges
STEINKÜHLER, Christian, KOCH, Uwe, NARJES, Frank, MATASSA, Victor G
Published in Current medicinal chemistry (01.07.2001)
Published in Current medicinal chemistry (01.07.2001)
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Characterization of the Hepatitis C Virus NS2/3 Processing Reaction by Using a Purified Precursor Protein
Pallaoro, M, Lahm, A, Biasiol, G, Brunetti, M, Nardella, C, Orsatti, L, Bonelli, F, Orrù, S, Narjes, F, Steinkühler, C
Published in Journal of Virology (01.10.2001)
Published in Journal of Virology (01.10.2001)
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Substrate Specificity of the Hepatitis C Virus Serine Protease NS3
Urbani, A, Bianchi, E, Narjes, F, Tramontano, A, De Francesco, R, Steinkühler, C, Pessi, A
Published in The Journal of biological chemistry (04.04.1997)
Published in The Journal of biological chemistry (04.04.1997)
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Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations
Shamovsky, Igor, Ripa, Lena, Narjes, Frank, Bonn, Britta, Schiesser, Stefan, Terstiege, Ina, Tyrchan, Christian
Published in Journal of medicinal chemistry (24.06.2021)
Published in Journal of medicinal chemistry (24.06.2021)
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