Diastereoselective, large-scale synthesis of beta-amino acids via asymmetric aza-Michael addition as alpha 2 delta ligands for the treatment of generalized anxiety disorder and insomnia
Magano, Javier, Bowles, Daniel, Conway, Brian, Nanninga, Thomas N., Winkle, Derick D.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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Diastereoselective, large scale synthesis of beta-amino acids via asymmetric enamide hydrogenation as alpha 2 delta ligands for the treatment of generalized anxiety disorder and insomnia
Magano, Javier, Conway, Brian, Bowles, Daniel, Nelson, Jade, Nanninga, Thomas N., Winkle, Derick D., Wu, Haifeng, Chen, Michael H.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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Development of a Scalable Process for CI-1034, an Endothelin Antagonist
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Published in Organic process research & development (01.03.2004)
Published in Organic process research & development (01.03.2004)
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THE SYNTHESIS OF (4R-CIS)-1,1-DIMETHYLETHYL 6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE, A KEY INTERMEDIATE FOR THE PREPARATION OF CI-981, A HIGHLY POTENT, TISSUE SELECTIVE INHIBITOR OF HMG-COA REDUCTASE
BROWER, PL, BUTLER, DE, DEERING, CF, LE, TV, MILLAR, A, NANNINGA, TN, ROTH, BD
Published in Tetrahedron letters (01.04.1992)
Published in Tetrahedron letters (01.04.1992)
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Journal Article
Diastereoselective, large-scale synthesis of β-amino acids via asymmetric aza-Michael addition as α2δ ligands for the treatment of generalized anxiety disorder and insomnia
Magano, Javier, Bowles, Daniel, Conway, Brian, Nanninga, Thomas N., Winkle, Derick D.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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Journal Article
Expeditious, large scale preparation of ethyl ( R)-5-methyl-3-oxo octanoate via a cross Claisen reaction between N-acyl oxazolidinone derivatives and the magnesium enolate of potassium ethyl malonate
Magano, Javier, Nanninga, Thomas N., Winkle, Derick D.
Published in Tetrahedron letters (28.04.2008)
Published in Tetrahedron letters (28.04.2008)
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Journal Article
Diastereoselective, large scale synthesis of β-amino acids via asymmetric enamide hydrogenation as α2δ ligands for the treatment of generalized anxiety disorder and insomnia
Magano, Javier, Conway, Brian, Bowles, Daniel, Nelson, Jade, Nanninga, Thomas N., Winkle, Derick D., Wu, Haifeng, Chen, Michael H.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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Chemoselectivity in palladium-mediated cycloadditions of substituted trimethylenemethanes
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Published in Journal of the American Chemical Society (01.02.1985)
Published in Journal of the American Chemical Society (01.02.1985)
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Carboxylative trimethylenemethane cycloadditions catalyzed by palladium
Trost, Barry M, Mignani, Serge M, Nanninga, Thomas N
Published in Journal of the American Chemical Society (01.09.1986)
Published in Journal of the American Chemical Society (01.09.1986)
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In Pursuit of Higher Purity: Use of 13 C NMR and 13 C-Enriched Substrates To Trace Impurity Generation and Removal in the Synthesis of Atorvastatin
Wade, Robert A., Zennie, Thomas M., Briggs, Christopher A., Jennings, Rex A., Nanninga, Thomas N., Palmer, Charles W., Clay, Ronald J.
Published in Organic process research & development (01.07.1997)
Published in Organic process research & development (01.07.1997)
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Palladium-mediated cycloaddition approach to loganin aglucon
Trost, Barry M., Nanninga, Thomas N.
Published in Journal of the American Chemical Society (01.03.1985)
Published in Journal of the American Chemical Society (01.03.1985)
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PREPARATION OF BETA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN
PEARLMAN, BRUCE A, HOGE, GARRETT, CONWAY, BRIAN GALVIN, NANNINGA, THOMAS N, WINKLE, DERICK DALE, WU, HAIFENG
Year of Publication 04.04.2007
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Year of Publication 04.04.2007
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PROCESS FOR MAKING N-ARYL-ANTHRANILIC ACIDS AND THEIR DERIVATIVES
MAGANO, JAVIER, CHEN, MICHAEL H, DAVIS, MARK E, WINKLE, DERICK D, NANNINGA, THOMAS N
Year of Publication 30.09.2004
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Year of Publication 30.09.2004
Patent