Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase
Cheney, I. Wayne, Yan, Shunqi, Appleby, Todd, Walker, Heli, Vo, Todd, Yao, Nanhua, Hamatake, Robert, Hong, Zhi, Wu, Jim Z.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase
De La Rosa, Martha, Kim, Hong Woo, Gunic, Esmir, Jenket, Cheryl, Boyle, Uyen, Koh, Yung-hyo, Korboukh, Ilia, Allan, Matthew, Zhang, Weijian, Chen, Huanming, Xu, Wen, Nilar, Shahul, Yao, Nanhua, Hamatake, Robert, Lang, Stanley A., Hong, Zhi, Zhang, Zhijun, Girardet, Jean-Luc
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors
Xu, Ying-zi, Yuan, Shendong, Bowers, Simeon, Hom, Roy K., Chan, Wayman, Sham, Hing L., Zhu, Yong L., Beroza, Paul, Pan, Hu, Brecht, Eric, Yao, Nanhua, Lougheed, Julie, Yan, Jiangli, Tam, Danny, Ren, Zhao, Ruslim, Lany, Bova, Michael P., Artis, Dean R.
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study
Yan, Shunqi, Appleby, Todd, Larson, Gary, Wu, Jim Z., Hamatake, Robert K., Hong, Zhi, Yao, Nanhua
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
Bowers, Simeon, Truong, Anh P., Jeffrey Neitz, R., Hom, Roy K., Sealy, Jennifer M., Probst, Gary D., Quincy, David, Peterson, Brian, Chan, Wayman, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Lin, May, Yao, Nanhua, Artis, Dean R., Zhang, Heather, Chen, Linda, Dryer, Mark, Samant, Bhushan, Zmolek, Wes, Wong, Karina, Lorentzen, Colin, Goldbach, Erich, Tonn, George, Quinn, Kevin P., Sauer, John-Michael, Wright, Sarah, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor
Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Structure of the hepatitis C virus RNA helicase domain
Yao, N, Hesson, T, Cable, M, Hong, Z, Kwong, A D, Le, H V, Weber, P C
Published in Nature structural biology (01.06.1997)
Published in Nature structural biology (01.06.1997)
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Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK
Hom, Roy K., Bowers, Simeon, Sealy, Jennifer M., Truong, Anh P., Probst, Gary D., Neitzel, Martin L., Neitz, R. Jeffrey, Fang, Larry, Brogley, Louis, Wu, Jing, Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Yao, Nanhua, Artis, Dean R., Quinn, Kevin, Sauer, John-Michael, Powell, Kyle, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Yan, Shunqi, Appleby, Todd, Gunic, Esmir, Shim, Jae Hoon, Tasu, Tania, Kim, Hongwoo, Rong, Frank, Chen, Huaming, Hamatake, Robert, Wu, Jim Z., Hong, Zhi, Yao, Nanhua
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease
Chen, Kevin X, Njoroge, F. George, Pichardo, John, Prongay, Andrew, Butkiewicz, Nancy, Yao, Nanhua, Madison, Vincent, Girijavallabhan, Viyyoor
Published in Journal of medicinal chemistry (26.01.2006)
Published in Journal of medicinal chemistry (26.01.2006)
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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents
Truong, Anh P., Probst, Gary D., Aquino, Jose, Fang, Larry, Brogley, Louis, Sealy, Jennifer M., Hom, Roy K., Tucker, John A., John, Varghese, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Tóth, Gergley, Yao, Nanhua, Brecht, Eric, Pan, Hu, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region
Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Stupi, Brian, Dressen, Darren, Jagodzinska, Barbara M., Aquino, Jose, Gailunas, Andrea, Truong, Anh P., Tso, Luke, Xu, Ying-Zi, Hom, Roy K., John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Sham, Hing L., Jagodzinski, Jacek, Toth, Gergely, Brecht, Eric, Yao, Nanhua, Pan, Hu, Lin, May, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Gauby, Shawn, Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycles
Chen, Kevin X, Njoroge, F. George, Arasappan, Ashok, Venkatraman, Srikanth, Vibulbhan, Bancha, Yang, Weiying, Parekh, Tejal N, Pichardo, John, Prongay, Andrew, Cheng, Kuo-Chi, Butkiewicz, Nancy, Yao, Nanhua, Madison, Vincent, Girijavallabhan, Viyyoor
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer
Appleby, Todd C, Luecke, Hartmut, Shim, Jae Hoon, Wu, Jim Z, Cheney, I Wayne, Zhong, Weidong, Vogeley, Lutz, Hong, Zhi, Yao, Nanhua
Published in Journal of Virology (01.01.2005)
Published in Journal of Virology (01.01.2005)
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Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors
El Abdellaoui, Hassan, Varaprasad, Chamakura V.N.S., Barawkar, Dinesh, Chakravarty, Subrata, Maderna, Andreas, Tam, Robert, Chen, Huanming, Allan, Matt, Wu, Jim Z., Appleby, Todd, Yan, Shunqi, Zhang, Weijian, Lang, Stanley, Yao, Nanhua, Hamatake, Robert, Hong, Zhi
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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Journal Article
Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease
Chen, Kevin X, Njoroge, F. George, Pichardo, John, Prongay, Andrew, Butkiewicz, Nancy, Yao, Nanhua, Madison, Vincent, Girijavallabhan, Viyyoor
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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