Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577
Smith, Aaron C, Kung, Daniel W, Shavnya, Andre, Brandt, Thomas A, Dent, Philip D, Genung, Nathan E, Cabral, Shawn, Panteleev, Jane, Herr, Michael, Yip, Ka Ning, Aspnes, Gary E, Conn, Edward L, Dowling, Matthew S, Edmonds, David J, Edmonds, Ian D, Fernando, Dilinie P, Herrinton, Paul M, Keene, Nandell F, Lavergne, Sophie Y, Li, Qifang, Polivkova, Jana, Rose, Colin R, Thuma, Benjamin A, Vetelino, Michael G, Wang, Guoqiang, Weaver, John D, Widlicka, Daniel W, Price Wiglesworth, Kristin E, Xiao, Jun, Zahn, Todd, Zhang, Yingxin
Published in Organic process research & development (15.06.2018)
Published in Organic process research & development (15.06.2018)
Get full text
Journal Article
Aqueous Phosphoric Acid as a Mild Reagent for Deprotection of tert-Butyl Carbamates, Esters, and Ethers
Li, Bryan, Berliner, Martin, Buzon, Richard, Chiu, Charles K.-F, Colgan, Stephen T, Kaneko, Takushi, Keene, Nandell, Kissel, William, Le, Tung, Leeman, Kyle R, Marquez, Brian, Morris, Ronald, Newell, Lisa, Wunderwald, Silke, Witt, Michael, Weaver, John, Zhang, Zhijun, Zhang, Zhongli
Published in Journal of organic chemistry (24.11.2006)
Published in Journal of organic chemistry (24.11.2006)
Get full text
Journal Article
Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors
Arcari, Joel T., Beebe, Jean S., Berliner, Martin A., Bernardo, Vincent, Boehm, Merin, Borzillo, Gary V., Clark, Tracey, Cohen, Bruce D., Connell, Richard D., Frost, Heather N., Gordon, Deborah A., Hungerford, William M., Kakar, Shefali M., Kanter, Aaron, Keene, Nandell F., Knauth, Elizabeth A., LaGreca, Susan D., Lu, Yong, Martinez-Alsina, Louis, Marx, Matthew A., Morris, Joel, Patel, Nandini C., Savage, Doug, Soderstrom, Cathy I., Thompson, Carl, Tkalcevic, George, Tom, Norma J., Vajdos, Felix F., Valentine, James J., Vincent, Patrick W., Wessel, Matthew D., Chen, Jinshan M.
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Get full text
Journal Article
Potent, selective pyrimidinetrione-based inhibitors of MMP-13
Reiter, Lawrence A., Freeman-Cook, Kevin D., Jones, Christopher S., Martinelli, Gary J., Antipas, Amy S., Berliner, Martin A., Datta, Kaushik, Downs, James T., Eskra, James D., Forman, Michael D., Greer, Elaine M., Guzman, Roberto, Hardink, Joel R., Janat, Fouad, Keene, Nandell F., Laird, Ellen R., Liras, Jennifer L., Lopresti-Morrow, Lori L., Mitchell, Peter G., Pandit, Jayvardhan, Robertson, Donald, Sperger, Diana, Vaughn-Bowser, Marcie L., Waller, Darra M., Yocum, Sue A.
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
Get full text
Journal Article
Early Process Development of Two Vanin‑1 Inhibitors: Solid Form Challenges and Control of Ambident Reactivity
Allais, Christophe, Casimiro-Garcia, Agustin, Dion, Amelie, Jensen, Andrew J., Keene, Nandell, Kumar, Rajesh, Li, Bryan, Lall, Manjinder S., McWilliams, J. Christopher, Wood, Geoffrey P. F., Wright, Stephen W., Yu, Shu
Published in Organic process research & development (21.06.2024)
Published in Organic process research & development (21.06.2024)
Get full text
Journal Article
Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497
Ashcroft, Christopher P., Berne, Alexander M., Blasberg, Florian, Catlin, Kelly, Collins, Michael R., Critcher, Doug J., Desrosiers, Jean-Nicolas, Goetz, Adam, Hayward, Cheryl, Jones, Ricky A., Karmilowicz, Michael J., Keene, Nandell, Martinez, Carlos A., Monfette, Sebastien, Pattavina, Sebastian David, Perfect, Hahdi H., Ragan, John A., Rauschenberger, Blake, Sach, Neal W., Scotney, Gemma, Sutton, Scott C., Talicska, Courtney, Twiddle, Steven J.R., Haitsma, Jared Van, Wisdom, Richard
Published in Organic process research & development (21.06.2024)
Published in Organic process research & development (21.06.2024)
Get full text
Journal Article
Photo-oxidation of Cyclopentadiene Using Continuous Processing: Application to the Synthesis of (1 R ,4 S )-4-Hydroxycyclopent-2-en-1-yl Acetate
Herrero-Gomez, Elena, van der Loo, Cornelis H. M., Huck, Lena, Rioz-Martínez, Ana, Keene, Nandell F., Li, Bryan, Pouwer, Kees, Allais, Christophe
Published in Organic process research & development (16.10.2020)
Published in Organic process research & development (16.10.2020)
Get full text
Journal Article