Advancing New Chemical Modalities into Clinical Studies
Blanco, Maria-Jesus, Gardinier, Kevin M., Namchuk, Mark N.
Published in ACS medicinal chemistry letters (10.11.2022)
Published in ACS medicinal chemistry letters (10.11.2022)
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In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment for Major Depressive Disorder
Bidlack, Jean M, Knapp, Brian I, Deaver, Daniel R, Plotnikava, Margarita, Arnelle, Derrick, Wonsey, Angela M, Toh, May Fenn, Pin, Sokhom S, Namchuk, Mark N
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
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Recognition of Divergent Viral Substrates by the SARS-CoV‑2 Main Protease
MacDonald, Elizabeth A, Frey, Gary, Namchuk, Mark N, Harrison, Stephen C, Hinshaw, Stephen M, Windsor, Ian W
Published in ACS infectious diseases (10.09.2021)
Published in ACS infectious diseases (10.09.2021)
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Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers
Toledo, Frederico G S, Martin, William F, Morrow, Linda, Beysen, Carine, Bajorunas, Daiva, Jiang, Ying, Silverman, Bernard L, McDonnell, David, Namchuk, Mark N, Newcomer, John W, Graham, Christine
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2022)
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2022)
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A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening
Gorgulla, Christoph, Padmanabha Das, Krishna M., Leigh, Kendra E., Cespugli, Marco, Fischer, Patrick D., Wang, Zi-Fu, Tesseyre, Guilhem, Pandita, Shreya, Shnapir, Alec, Calderaio, Anthony, Gechev, Minko, Rose, Alexander, Lewis, Noam, Hutcheson, Colin, Yaffe, Erez, Luxenburg, Roni, Herce, Henry D., Durmaz, Vedat, Halazonetis, Thanos D., Fackeldey, Konstantin, Patten, J.J., Chuprina, Alexander, Dziuba, Igor, Plekhova, Alla, Moroz, Yurii, Radchenko, Dmytro, Tarkhanova, Olga, Yavnyuk, Irina, Gruber, Christian, Yust, Ryan, Payne, Dave, Näär, Anders M., Namchuk, Mark N., Davey, Robert A., Wagner, Gerhard, Kinney, Jamie, Arthanari, Haribabu
Published in iScience (19.02.2021)
Published in iScience (19.02.2021)
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Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control
Aronov, Alex M, Tang, Qing, Martinez-Botella, Gabriel, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ewing, Nigel P, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Markland, William, Namchuk, Mark N, Nanthakumar, Suganthini, Poondru, Srinivasu, Straub, Judy, ter Haar, Ernst, Xie, Xiaoling
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
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Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization
Patten, J.J., Keiser, Patrick T., Morselli-Gysi, Deisy, Menichetti, Giulia, Mori, Hiroyuki, Donahue, Callie J., Gan, Xiao, Valle, Italo do, Geoghegan-Barek, Kathleen, Anantpadma, Manu, Boytz, RuthMabel, Berrigan, Jacob L., Stubbs, Sarah H., Ayazika, Tess, O’Leary, Colin, Jalloh, Sallieu, Wagner, Florence, Ayehunie, Seyoum, Elledge, Stephen J., Anderson, Deborah, Loscalzo, Joseph, Zitnik, Marinka, Gummuluru, Suryaram, Namchuk, Mark N., Barabási, Albert-László, Davey, Robert A.
Published in iScience (16.09.2022)
Published in iScience (16.09.2022)
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184 Insulin Sensitivity and Glucose Metabolism of Olanzapine and Combination Olanzapine and Samidorphan: A Phase 1 Exploratory Study in Healthy Volunteers
Martin, William, Graham, Christine, Morrow, Linda, Beysen, Carine, Toledo, Frederico G S, Bajorunas, Daiva, Jiang, Ying, Silverman, Bernard, McDonnell, David, Namchuk, Mark N, Newcomer, John W
Published in CNS spectrums (01.04.2020)
Published in CNS spectrums (01.04.2020)
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Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors
Aronov, Alex M, Baker, Christopher, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Martinez-Botella, Gabriel, Namchuk, Mark N, Straub, Judy, Tang, Qing, Xie, Xiaoling
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
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c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo
Shao, Zhili, Bhattacharya, Kausik, Hsich, Eileen, Park, Larry, Walters, Brian, Germann, Ursula, Wang, Yow-Ming, Kyriakis, John, Mohanlal, Ramon, Kuida, Keisuke, Namchuk, Mark, Salituro, Francesco, Yao, Yung-mae, Hou, Wei-min, Chen, Xin, Aronovitz, Mark, Tsichlis, Philip N, Bhattacharya, Susmita, Force, Thomas, Kilter, Heiko
Published in Circulation research (06.01.2006)
Published in Circulation research (06.01.2006)
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The Role of Sugar Substituents in Glycoside Hydrolysis
Namchuk, Mark N, McCarter, John D, Becalski, Adam, Andrews, Trevor, Withers, Stephen G
Published in Journal of the American Chemical Society (23.02.2000)
Published in Journal of the American Chemical Society (23.02.2000)
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Design, Synthesis, and Evaluation of a Novel Dual Fms-Like Tyrosine Kinase 3/Stem Cell Factor Receptor (FLT3/c-KIT) Inhibitor for the Treatment of Acute Myelogenous Leukemia
Davies, Robert J, Pierce, Albert C, Forster, Cornelia, Grey, Ron, Xu, Jinwang, Arnost, Michael, Choquette, Deborah, Galullo, Vincent, Tian, Shi-Kai, Henkel, Greg, Chen, Guanjing, Heidary, David K, Ma, Joanne, Stuver-Moody, Cameron, Namchuk, Mark
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors
Giroux, Simon, Xu, Jinwang, Reddy, T. Jagadeeswar, Morris, Mark, Cottrell, Kevin M, Cadilhac, Caroline, Henderson, James A, Nicolas, Oliver, Bilimoria, Darius, Denis, Francois, Mani, Nagraj, Ewing, Nigel, Shawgo, Rebecca, L’Heureux, Lucille, Selliah, Subajini, Chan, Laval, Chauret, Nathalie, Berlioz-Seux, Francoise, Namchuk, Mark N, Grillot, Anne-Laure, Bennani, Youssef L, Das, Sanjoy K, Maxwell, John P
Published in ACS medicinal chemistry letters (13.03.2014)
Published in ACS medicinal chemistry letters (13.03.2014)
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In Vivo Characterization of the Opioid Receptor Binding Profiles of Samidorphan and Naltrexone in Rats: Comparisons at Clinically Relevant Concentrations
Tan, Laura, Gajipara, Nilesh, Zhou, Ying, Namchuk, Mark N., Cunningham, Jacobi
Published in Biological psychiatry (1969) (01.05.2021)
Published in Biological psychiatry (1969) (01.05.2021)
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Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)
Germann, Ursula A, Furey, Brinley F, Markland, William, Hoover, Russell R, Aronov, Alex M, Roix, Jeffrey J, Hale, Michael, Boucher, Diane M, Sorrell, David A, Martinez-Botella, Gabriel, Fitzgibbon, Matthew, Shapiro, Paul, Wick, Michael J, Samadani, Ramin, Meshaw, Kathryn, Groover, Anna, DeCrescenzo, Gary, Namchuk, Mark, Emery, Caroline M, Saha, Saurabh, Welsch, Dean J
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo
Patten, J J, Keiser, Patrick T, Gysi, Deisy, Menichetti, Giulia, Mori, Hiroyuki, Donahue, Callie J, Gan, Xiao, do Valle, Italo, Geoghegan-Barek, Kathleen, Anantpadma, Manu, Boytz, RuthMabel, Berrigan, Jacob L, Hulsey-Stubbs, Sarah, Ayazika, Tess, O'Leary, Colin, Jalloh, Sallieu, Wagner, Florence, Ayehunie, Seyoum, Elledge, Stephen J, Anderson, Deborah, Loscalzo, Joseph, Zitnik, Marinka, Gummuluru, Suryaram, Namchuk, Mark N, Barabási, Albert-László, Davey, Robert A
Published in bioRxiv : the preprint server for biology (01.02.2022)
Published in bioRxiv : the preprint server for biology (01.02.2022)
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