The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
Katayama, Ryohei, Gong, Bo, Togashi, Noriko, Miyamoto, Masaya, Kiga, Masaki, Iwasaki, Shiho, Kamai, Yasuki, Tominaga, Yuichi, Takeda, Yasuyuki, Kagoshima, Yoshiko, Shimizu, Yuki, Seto, Yosuke, Oh-hara, Tomoko, Koike, Sumie, Nakao, Naoki, Hanzawa, Hiroyuki, Watanabe, Kengo, Yoda, Satoshi, Yanagitani, Noriko, Hata, Aaron N., Shaw, Alice T., Nishio, Makoto, Fujita, Naoya, Isoyama, Takeshi
Published in Nature communications (09.08.2019)
Published in Nature communications (09.08.2019)
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Novel LCAT (Lecithin: Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models
Sasaki, Masato, Delawary, Mina, Sakurai, Hidetaka, Kobayashi, Hideki, Nakao, Naoki, Tsuru, Hiromi, Fukushima, Yumiko, Honzumi, Shoko, Moriyama, Sachiko, Wada, Naoya, Kaneko, Toshio, Yamada, Keisuke, Terasaka, Naoki, Kubota, Kazuishi
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2021)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2021)
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Journal Article
Four cases of cytokine storm after COVID-19 vaccination: Case report
Murata, Kazuhiro, Nakao, Naoki, Ishiuchi, Naoki, Fukui, Takafumi, Katsuya, Narutaka, Fukumoto, Wataru, Oka, Hiroko, Yoshikawa, Naotaka, Nagao, Takafumi, Namera, Akira, Kakimoto, Naoya, Oue, Naohide, Awai, Kazuo, Yoshimoto, Kanji, Nagao, Masataka
Published in Frontiers in immunology (15.08.2022)
Published in Frontiers in immunology (15.08.2022)
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Comparison of therapeutic effects of mesenchymal stem cells derived from superficial and deep subcutaneous adipose tissues
Ishiuchi, Naoki, Nakashima, Ayumu, Maeda, Satoshi, Miura, Yoshie, Miyasako, Kisho, Sasaki, Kensuke, Uchiki, Toshio, Sasaki, Ayano, Nagamatsu, Shogo, Nakao, Naoki, Nagao, Masataka, Masaki, Takao
Published in Stem cell research & therapy (04.05.2023)
Published in Stem cell research & therapy (04.05.2023)
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Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Nakao, Naoki, Ueno, Masaharu, Sakai, Shota, Egawa, Daichi, Hanzawa, Hiroyuki, Kawasaki, Shohei, Kumagai, Keigo, Suzuki, Makoto, Kobayashi, Shu, Hanada, Kentaro
Published in Communications chemistry (20.02.2019)
Published in Communications chemistry (20.02.2019)
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Journal Article
Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers
Miura, Shin-Ichiro, Nakao, Naoki, Hanzawa, Hiroyuki, Matsuo, Yoshino, Saku, Keijiro, Karnik, Sadashiva S
Published in PloS one (08.11.2013)
Published in PloS one (08.11.2013)
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Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Goto, Taiji, Shiina, Akiko, Yoshino, Toshiharu, Mizukami, Kiyoshi, Hirahara, Kazuki, Suzuki, Osamu, Sogawa, Yoshitaka, Takahashi, Tomoko, Mikkaichi, Tsuyoshi, Nakao, Naoki, Takahashi, Mizuki, Hasegawa, Masashi, Sasaki, Shigeki
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Journal Article
Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Goto, Taiji, Shiina, Akiko, Yoshino, Toshiharu, Mizukami, Kiyoshi, Hirahara, Kazuki, Suzuki, Osamu, Sogawa, Yoshitaka, Takahashi, Tomoko, Mikkaichi, Tsuyoshi, Nakao, Naoki, Takahashi, Mizuki, Hasegawa, Masashi, Sasaki, Shigeki
Published in Bioorganic & medicinal chemistry (15.11.2013)
Published in Bioorganic & medicinal chemistry (15.11.2013)
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Journal Article
Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors
Goto, Taiji, Shiina, Akiko, Murata, Takeshi, Tomii, Masato, Yamazaki, Takanori, Yoshida, Ken-ichi, Yoshino, Toshiharu, Suzuki, Osamu, Sogawa, Yoshitaka, Mizukami, Kiyoshi, Takagi, Nana, Yoshitomi, Tomomi, Etori, Maki, Tsuchida, Hiroshi, Mikkaichi, Tsuyoshi, Nakao, Naoki, Takahashi, Mizuki, Takahashi, Hisashi, Sasaki, Shigeki
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor
Miura, Shin-ichiro, Kiya, Yoshihiro, Hanzawa, Hiroyuki, Nakao, Naoki, Fujino, Masahiro, Imaizumi, Satoshi, Matsuo, Yoshino, Yanagisawa, Hiroaki, Koike, Hiroyuki, Komuro, Issei, Karnik, Sadashiva S, Saku, Keijiro
Published in PloS one (14.06.2012)
Published in PloS one (14.06.2012)
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Clinical and genetic characterizations of 16q-linked autosomal dominant spinocerebellar ataxia (AD-SCA) and frequency analysis of AD-SCA in the Japanese population
Nozaki, Hiroaki, Ikeuchi, Takeshi, Kawakami, Akio, Kimura, Akio, Koide, Reiji, Tsuchiya, Miyuki, Nakmura, Yuusaku, Mutoh, Tatsuro, Yamamoto, Hiroko, Nakao, Naoki, Sahashi, Ko, Nishizawa, Masatoyo, Onodera, Osamu
Published in Movement disorders (30.04.2007)
Published in Movement disorders (30.04.2007)
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Multiple Endocrine Neoplasia Type I and Cushing's Syndrome Due to an Aggressive ACTH Producing Thymic Carcinoid
Takagi, Junko, Otake, Kazuo, Morishita, Munehiko, Kato, Harumichi, Nakao, Naoki, Yoshikawa, Kazuhiro, Ikeda, Hiroshi, Hirooka, Yoshifumi, Hattori, Yoshinobu, Larsson, Catharina, Nogimori, Tsuyoshi
Published in Internal Medicine (01.01.2006)
Published in Internal Medicine (01.01.2006)
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(R)salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes
Naoi, M, Maruyama, W, Nakao, N, Ibi, T, Sahashi, K, Benedetti, M S
Published in Annals of neurology (01.02.1998)
Published in Annals of neurology (01.02.1998)
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U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors
Papadopoulos, Kyriakos P, Borazanci, Erkut, Shaw, Alice T, Katayama, Ryohei, Shimizu, Yuki, Zhu, Viola W, Sun, Thomas Yang, Wakelee, Heather A, Madison, Russell, Schrock, Alexa B, Senaldi, Giorgio, Nakao, Naoki, Hanzawa, Hiroyuki, Tachibana, Masaya, Isoyama, Takeshi, Nakamaru, Kenji, Deng, Chenhui, Li, Meijing, Fan, Frank, Zhao, Qinying, Gao, Yanfei, Seto, Takashi, Jänne, Pasi A, Ou, Sai-Hong Ignatius
Published in Clinical cancer research (15.09.2020)
Published in Clinical cancer research (15.09.2020)
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Age estimation using post-mortem computed tomography and fetal dental radiographic findings in an early to mid-pregnancy fetus: A case report
Oka, Hiroko, Asao, Yuria, Ohbayashi, Nami, Nakao, Naoki, Ishiuchi, Naoki, Fukumoto, Wataru, Matsumoto, Yoriaki, Kakimoto, Naoya, Nagao, Masataka, Kozai, Katsuyuki
Published in Legal medicine (Tokyo, Japan) (01.05.2023)
Published in Legal medicine (Tokyo, Japan) (01.05.2023)
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