Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis
Kitajima, Yuya, Ishii, Takuya, Kohda, Takeo, Ishizuka, Masahiro, Yamazaki, Kanami, Nishimura, Yumiko, Tanaka, Tohru, Dan, Shingo, Nakajima, Motowo
Published in Scientific reports (17.06.2019)
Published in Scientific reports (17.06.2019)
Get full text
Journal Article
Efficiency of aminolevulinic acid (ALA)-photodynamic therapy based on ALA uptake transporters in a cell density-dependent malignancy model
Lai, Hung Wei, Takahashi, Kiwamu, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro
Published in Journal of photochemistry and photobiology. B, Biology (01.05.2021)
Published in Journal of photochemistry and photobiology. B, Biology (01.05.2021)
Get full text
Journal Article
The Uptake of Heparanase into Mast Cells Is Regulated by Its Enzymatic Activity to Degrade Heparan Sulfate
Shi, Jia, Onuki, Yoshiki, Kawanami, Fumiya, Miyagawa, Naoko, Iwasaki, Fumika, Tsuda, Haruna, Takahashi, Katsuhiko, Oku, Teruaki, Suzuki, Masato, Higashi, Kyohei, Adachi, Hayamitsu, Nishimura, Yoshio, Nakajima, Motowo, Irimura, Tatsuro, Higashi, Nobuaki
Published in International journal of molecular sciences (01.06.2024)
Published in International journal of molecular sciences (01.06.2024)
Get full text
Journal Article
5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice
Saitoh, Shinichi, Okano, Satoshi, Nohara, Hidekazu, Nakano, Hiroshi, Shirasawa, Nobuyuki, Naito, Akira, Yamamoto, Masayuki, Kelly, Vincent P, Takahashi, Kiwamu, Tanaka, Tohru, Nakajima, Motowo, Nakajima, Osamu
Published in PloS one (01.01.2018)
Published in PloS one (01.01.2018)
Get full text
Journal Article
Chondroitin sulfate E blocks enzymatic action of heparanase and heparanase-induced cellular responses
Higashi, Nobuaki, Maeda, Rino, Sesoko, Nakaba, Isono, Momoko, Ishikawa, Sodai, Tani, Yurina, Takahashi, Katsuhiko, Oku, Teruaki, Higashi, Kyohei, Onishi, Shoichi, Nakajima, Motowo, Irimura, Tatsuro
Published in Biochemical and biophysical research communications (26.11.2019)
Published in Biochemical and biophysical research communications (26.11.2019)
Get full text
Journal Article
Molecular basis for the actions of Hsp90 inhibitors and cancer therapy
Yamaki, Hiroshi, Nakajima, Motowo, Shimotohno, Kumiko W, Tanaka, Nobuo
Published in Journal of antibiotics (01.09.2011)
Published in Journal of antibiotics (01.09.2011)
Get full text
Journal Article
5-Aminolevulinic acid-mediated photodynamic therapy using light-emitting diodes of different wavelengths in a mouse model of peritoneally disseminated gastric cancer
Hino, Hitoshi, MD, Murayama, Yasutoshi, MD, PhD, Nakanishi, Masayoshi, MD, PhD, Inoue, Katsushi, MEng, Nakajima, Motowo, PhD, Otsuji, Eigo, MD, PhD
Published in The Journal of surgical research (01.11.2013)
Published in The Journal of surgical research (01.11.2013)
Get full text
Journal Article
5‐ALA/SFC Attenuated Binge Alcohol–Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats
Liu, Chi, Zhu, Ping, Fujino, Masayuki, Zhu, Shuoji, Ito, Hidenori, Takahashi, Kiwamu, Nakajima, Motowo, Tanaka, Tohru, Zhuang, Jian, Li, Xiao‐Kang
Published in Alcoholism, clinical and experimental research (01.08.2019)
Published in Alcoholism, clinical and experimental research (01.08.2019)
Get full text
Journal Article
5‐Aminolevulinic acid/sodium ferrous citrate enhanced the antitumor effects of programmed cell death‐ligand 1 blockade by regulation of exhausted T cell metabolism in a melanoma model
Hu, Xin, Que, Weitao, Hirano, Hiroshi, Wang, Zhidan, Nozawa, Naoko, Ishii, Takuya, Ishizuka, Masahiro, Ito, Hidenori, Takahashi, Kiwamu, Nakajima, Motowo, Tanaka, Tohru, Zhu, Ping, Guo, Wen‐Zhi, Li, Xiao‐Kang
Published in Cancer science (01.07.2021)
Published in Cancer science (01.07.2021)
Get full text
Journal Article
5-Aminolevulinic acid regulates the immune response in LPS-stimulated RAW 264.7 macrophages
Sugiyama, Yuta, Hiraiwa, Yukari, Hagiya, Yuichiro, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-Ichiro
Published in BMC immunology (19.12.2018)
Published in BMC immunology (19.12.2018)
Get full text
Journal Article
Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells
Shi, Jia, Kanoya, Riku, Tani, Yurina, Ishikawa, Sodai, Maeda, Rino, Suzuki, Sana, Kawanami, Fumiya, Miyagawa, Naoko, Takahashi, Katsuhiko, Oku, Teruaki, Yamamoto, Ami, Fukuzawa, Kaori, Nakajima, Motowo, Irimura, Tatsuro, Higashi, Nobuaki
Published in International journal of molecular sciences (02.05.2022)
Published in International journal of molecular sciences (02.05.2022)
Get full text
Journal Article
A Randomized Phase 2 Study of 5-Aminolevulinic Acid Hydrochloride and Sodium Ferrous Citrate for the Prevention of Nephrotoxicity Induced by Cisplatin-Based Chemotherapy of Lung Cancer
Kawamura, Kodai, Matsushima, Hidekazu, Sakai, Hiroshi, Iwashima, Akira, Nakamura, Sukeyuki, Kojima, Tohru, Sasaki, Shinichi, Shigenaga, Takehiko, Natsume, Ichiro, Sasaki, Takaaki, Ohsaki, Yoshinobu, Iwanaga, Kentaro, Nishi, Koichi, Mitsuishi, Yoichiro, Taniguchi, Hirokazu, Sato, Kazuhiro, Yamauchi, Mitsugu, Nakajima, Motowo, Takahashi, Kazuhisa
Published in Oncology (01.12.2022)
Published in Oncology (01.12.2022)
Get full text
Journal Article
Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy
Nakayama, Taku, Otsuka, Shimpei, Kobayashi, Tatsuya, Okajima, Hodaka, Matsumoto, Kentaro, Hagiya, Yuichiro, Inoue, Keiji, Shuin, Taro, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-Ichiro
Published in Scientific reports (18.11.2016)
Published in Scientific reports (18.11.2016)
Get full text
Journal Article
Treatment of sarcopenia and glucose intolerance through mitochondrial activation by 5-aminolevulinic acid
Fujii, Chikako, Miyashita, Kazutoshi, Mitsuishi, Masanori, Sato, Masaaki, Fujii, Kentaro, Inoue, Hiroyuki, Hagiwara, Aika, Endo, Sho, Uto, Asuka, Ryuzaki, Masaki, Nakajima, Motowo, Tanaka, Tohru, Tamaki, Masanori, Muraki, Ayako, Kawai, Toshihide, Itoh, Hiroshi
Published in Scientific reports (21.06.2017)
Published in Scientific reports (21.06.2017)
Get full text
Journal Article
Incorporation, intracellular trafficking and processing of extracellular heparanase by mast cells: Involvement of syndecan-4-dependent pathway
Higashi, Nobuaki, Waki, Michihiko, Sudo, Yukiaki, Suzuki, Sana, Oku, Teruaki, Tsuiji, Makoto, Tsuji, Tsutomu, Miyagishi, Makoto, Takahashi, Katsuhiko, Nakajima, Motowo, Irimura, Tatsuro
Published in Biochemical and biophysical research communications (18.09.2018)
Published in Biochemical and biophysical research communications (18.09.2018)
Get full text
Journal Article
Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study
Suzuki, Hiroshi, Masuki, Shizue, Morikawa, Akiyo, Ogawa, Yu, Kamijo, Yoshi-Ichiro, Takahashi, Kiwamu, Nakajima, Motowo, Nose, Hiroshi
Published in Scientific reports (08.05.2018)
Published in Scientific reports (08.05.2018)
Get full text
Journal Article
Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines
Tsunekawa, Naoki, Higashi, Nobuaki, Kogane, Yusuke, Waki, Michihiko, Shida, Hiroaki, Nishimura, Yoshio, Adachi, Hayamitsu, Nakajima, Motowo, Irimura, Tatsuro
Published in Biochemical and biophysical research communications (22.01.2016)
Published in Biochemical and biophysical research communications (22.01.2016)
Get full text
Journal Article
5-Aminolevulinic acid with ferrous iron improves early renal damage and hepatic steatosis in high fat diet-induced obese mice
Kamiya, Atsuko, Hara, Takeshi, Tsuda, Masayuki, Tsuru, Emi, Kuroda, Yasushi, Ota, Urara, Karashima, Takashi, Fukuhara, Hideo, Inoue, Keiji, Ishizuka, Masahiro, Nakajima, Motowo, Tanaka, Tohru
Published in Journal of Clinical Biochemistry and Nutrition (01.01.2019)
Published in Journal of Clinical Biochemistry and Nutrition (01.01.2019)
Get full text
Journal Article
Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake
Lai, Hung Wei, Sasaki, Ryuta, Usuki, Shiro, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro
Published in Photodiagnosis and photodynamic therapy (01.09.2019)
Published in Photodiagnosis and photodynamic therapy (01.09.2019)
Get full text
Journal Article